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Effect of consuming vegetable first and carbohydrate last on preventing atheroscrocis in patients with type 2 diabetes

Research Project

Project/Area Number 23500809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKyoto Women's University (2015)
Osaka Prefecture University (2011-2014)

Principal Investigator

Imai Saeko  京都女子大学, 家政学部, 教授 (00438235)

Co-Investigator(Kenkyū-buntansha) FUKUI Michiaki  京都府立医科大学, 医学研究科, 教授 (30247829)
Co-Investigator(Renkei-kenkyūsha) OZASA Neiko  京都大学, 医学研究科, 助教 (30467485)
Research Collaborator KAJIYAMA Shizuo  梶山内科クリニック, 院長・糖尿病専門医
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords食事療法 / 糖尿病 / 栄養指導 / 食後高血糖 / 動脈硬化 / 血糖変動 / 持続血糖測定
Outline of Final Research Achievements

To examine the chronic effect of the food order, we explored the level of HbA1c and intima media thickness (IMT) in carotid artery which showed the progression of arteriosclerosis in two groups with and without intervention of patients with type 2 diabetes. The level of HbA1c decreased significantly after intervention compared with those in baseline in the intervention group, while no change was observed in the control group after 4.4 years. We observed no significant change in Max IMT and mean IMT of both groups after intervention compared to those in baseline. We assumed the other factors such as lipid-lowering medicine, and anti-hypertension medicine influenced on the levels of IMT as well as the diet of food order .

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (45 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (31 results) (of which Int'l Joint Research: 1 results,  Invited: 11 results) Book (4 results)

  • [Journal Article] Comment on Shukla et al. Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels. Diabetes Care 2015;38:e98-e99.2015

    • Author(s)
      Imai S, Fukui M, Kajiyama S
    • Journal Title

      Diabetes Care

      Volume: 38(11) Issue: 11 Pages: e196-e196

    • DOI

      10.2337/dc15-1472

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 炭水化物の前に野菜を食べると2型糖尿病患者の血糖変動にどのような効果をもたらすか2015

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      Calm̴Approach to Glycemic Variation

      Volume: 2 Pages: 10-13

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 炭水化物の前に野菜を摂取する食事法が2型糖尿病患者の血糖変動幅に及ぼす影響2015

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      KISSEI KUR8(3);13-14,2015

      Volume: 8(3) Pages: 13-14

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effect of eating vegetables before carbohydrates on glucose excursions in patients with type 2 diabetes2014

    • Author(s)
      Imai S, Fukui M, Kajiyama S
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Pages: 7-11

    • NAID

      130004466733

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] What to eat first and how to eat to reduce amplitude of glycemic excursions2014

    • Author(s)
      Imai S, Kajiyama S
    • Journal Title

      Journalof Life Science Research,

      Volume: 12 Pages: 3-7

    • NAID

      120005651639

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eating Vegetables Before Carbohydrates Improves Postprandial Glucose Excursions2013

    • Author(s)
      Imai S, Fukui M, Ozasa N, Ozeki T, Kurokawa M, Tatsushi Komatsu, Shizuo Kajiyama
    • Journal Title

      Diabetic Medicine

      Volume: 30 Issue: 3 Pages: 370-372

    • DOI

      10.1111/dme.12073

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Second- meal effect of consuming snacks at mid-afternoon in patients with type 2 diabetes2013

    • Author(s)
      IMAI S, FUKUI M, OZASA N, KAJIYAMA S
    • Journal Title

      Diabetologia

      Volume: (Suppl1) 56

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 糖尿病の今 食品の摂取スタイルと血糖への影響2012

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      公衆衛生

      Volume: 76 Pages: 796-799

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大学と医療機関による糖尿病食事療法の共同研究2012

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      栄養 評価と治療

      Volume: 29 Pages: 5-10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eating Vegetables Before Carbohydrates Improved Daily Acute Glucose Fluctuations Assessed by Using Continuous Glucose Monitoring in Subjects with Type 2 Diabetes and Normal Glucose Tolerance2012

    • Author(s)
      Saeko Imai, Michiaki Fukui, Neiko Ozasa, Onkoo Rhee, Shizuo Kajiyama
    • Journal Title

      Diabetes

      Volume: 61.Suppl.(1)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 肥満診療と食事療法の実際~健康長寿をめざす食べる順番~2016

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第55回中部防衛衛生学会
    • Place of Presentation
      舞鶴市商工観光センター
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 何から食べるか?~健康長寿をめざす食べる順番~2016

    • Author(s)
      今井佐恵子
    • Organizer
      京都市国民健康保険「健康づくり講演会」
    • Place of Presentation
      京都市シルクホール
    • Year and Date
      2016-01-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 食べ方の順序による血糖変動抑制効果2016

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第19回日本病態栄養学会年次学術集会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2016-01-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 4 Effect of Eating Vegetables before Carbohydrates on Glucose Excursions in Patients with Type 2 Diabetes2015

    • Author(s)
      Imai S, Kajiyama S
    • Organizer
      BIT's 4th annual congress of Diabets 2015
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 食後血糖・血糖変動を抑制する食べ方の順序とは?2015

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第49回糖尿病学の進歩
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Glucose spikes of eating vegetables before carbohydrates with snacks at mid-afternoon are lower than eating carbohydrates before vegetables without snacks2014

    • Author(s)
      Imai S, Fukui M, Ozasa N, Kajiyama S
    • Organizer
      50th EASD (European Association for the Study of Diabetes)
    • Place of Presentation
      Viena,Austlia
    • Year and Date
      2014-09-15 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 食べる順番と食後高血糖2014

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      日本臨床栄養学会
    • Place of Presentation
      千葉大学医学部
    • Year and Date
      2014-09-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] CONSUMING SNACKS AT 15:30 REDUCED GLUCOSE EXCURSIONS COMPARE TO AT 12:30 IN DIABETIC PATIENTS2014

    • Author(s)
      Imai S, Komatsu T, Rhee O, Kajiyama S
    • Organizer
      6th Asian Congress of Dietetics (ACD)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2014-08-21 – 2014-08-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 間食の摂取時間の違いが食後血糖値および食後血糖上昇曲線下面積に与える影響2014

    • Author(s)
      今井佐恵子、福井道明, 小笹寧子, 梶山静夫
    • Organizer
      第57日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of eating vegetables before carbohydrates on daily glucose fluctuations and long-term glycaemic control in patients with type 2 diabetes2014

    • Author(s)
      SAEKO IMAI, SHIZUO KAJIYAMA
    • Organizer
      The 7th International Immunonutrition Workshop
    • Place of Presentation
      Bari, Puglia, Italy
    • Year and Date
      2014-05-01 – 2014-05-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 間食の摂取時間の違いが食後血糖値および食後血糖上昇曲線下面積に与える影響2014

    • Author(s)
      今井佐恵子, 福井道明, 小笹寧子, 梶山静夫
    • Organizer
      第57日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] SATISFACTION WITH CLINICAL USE OF CONTINUOUS GLUCOSE MONITORING SYSTEM (CGMS) IN JAPANESE PEOPLE WITH DIABETES AND WITH NORMAL GLUCOSE TOLERANCE2013

    • Author(s)
      Imai S, Matsuda M , Kajiyama S
    • Organizer
      20th ICN (International Congress of Nutrition)
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Second- meal effect of consuming snacks at mid-afternoon in patients with type 2 diabetes2013

    • Author(s)
      IMAI S, FUKUI M, OZASA N, KAJIYAMA S
    • Organizer
      49th EASD 2013
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病治療における食事療法Update 食品の摂取順序のちがいによる食後血糖値および血糖変動の変化2013

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第86回日本内分泌学会クリニカルアワー
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 食べ方と血糖管理2013

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第35回日本臨床栄養学会総会・第4回日本臨床栄養協会総会ワークショップ 京都
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 食事の摂取スタイルと血糖変動への影響2013

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      日本医師会生涯教育講座 第18回道央地区糖尿病勉強会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 食品の摂取スタイルがもたらす血糖変動2013

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第10回八尾地区糖尿病研究会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 2型糖尿病患者における間食付加による血糖値の変化2013

    • Author(s)
      榛葉真由香, 川口早紀, 梶山静夫, 今井佐恵子
    • Organizer
      第12回日本栄養改善学会近畿支部会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 健常者および糖尿病患者に対する持続血糖測定器(CGMS)の満足度調査2013

    • Author(s)
      川口早紀, 榛葉真由香, 梶山静夫, 今井佐恵子
    • Organizer
      第12回日本栄養改善学会近畿支部会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 食品の摂取順序の違いによる食後血糖最大増加値の変化2013

    • Author(s)
      長田知佳子、梶山静夫、福井道明、小笹寧子、今井佐恵子
    • Organizer
      第16回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] SATISFACTION WITH CLINICAL USE OF CONTINUOUS GLUCOSE MONITORING SYSTEM (CGMS) IN JAPANESE PEOPLE WITH DIABETES AND WITH NORMAL GLUCOSE TOLERANCE2013

    • Author(s)
      Imai S ; Matsuda M , Kajiyama S
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] 食べる順番療法による血糖変動抑制効果 ―CGMによるクロスオーバー研究―2012

    • Author(s)
      今井佐恵子, 福井道明, 小笹寧子, 梶山静夫
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Eating Vegetables Before Carbohydrates Improved Daily Acute Glucose Fluctuations Assessed by Using Continuous Glucose Monitoring in Subjects with Type 2 Diabetes and Normal Glucose Tolerance2012

    • Author(s)
      Saeko Imai, Michiaki Fukui, Neiko Ozasa, Onkoo Rhee, Shizuo Kajiyama
    • Organizer
      72nd Scientific sessions, ADA2012
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Crossover study of the effect of Vegetables before Carbohydrate on daily acute glucose fluctuations assessed using continuous glucose monitoring (CGM) in Japanese with normal glucose tolerance2012

    • Author(s)
      Saeko Imai, Mikuko Matsuda, Tatsuo Komatsu,Onkoo Rhee, Shizuo Kajiyama
    • Organizer
      ICD 2012 (International Congress of Dietitians 2012)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2012 Research-status Report
  • [Presentation] Dietary Education of Eating Vegetables Before Carbohydrates Improves Postprandial Glucose Excurtions Assessed by Continuous Glucose Monitoring System in Elderly Patients with Type 2 Diabetes2012

    • Author(s)
      SAEKO IMAI, EMI SHIMOYMA, MICHIAKI FUKUI, , SHIZUO KAJIYAMA
    • Organizer
      Al l Tigether Better Health 4 Symposium
    • Place of Presentation
      Kobe
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Eating Vegetables Before Carbohydrates Improves Postprandial Glucose Excursions Assessed by CGMS Both in DM and in NGT2012

    • Author(s)
      SAEKO IMAI, MICHIAKI FUKUI, NEIKO OZASA, MICHINORI KUROKAWA, RIKIO TAKAO, MAKIHIKO KUHARA, CHIKAKO NAGATA, SHIZUO KAJIYAMA
    • Organizer
      9th international Diabetes Federation-Western Pacific Region Congress
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] 食品の摂取順序のちがいによるCGMSの日内変動2011

    • Author(s)
      今井佐恵子、 松田美久子、 梶山静夫
    • Organizer
      第58回日本栄養改善学会学術総会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] 食品の摂取順序のちがいによる持続血糖測定 (CGM) 第一報-健常者の場合-2011

    • Author(s)
      川上愛加,今井佐恵子,倉本有梨,竹山育子,梶山静夫
    • Organizer
      第10回日本栄養改善学会近畿支部会
    • Place of Presentation
      奈良
    • Related Report
      2011 Research-status Report
  • [Presentation] 食品の摂取順序のちがいによる持続血糖測定 (CGM) 第二報―糖尿病患者の場合―2011

    • Author(s)
      倉本有梨,今井佐恵子,川上愛加,竹山育子,梶山静夫
    • Organizer
      第10回日本栄養改善学会近畿支部会
    • Place of Presentation
      奈良
    • Related Report
      2011 Research-status Report
  • [Presentation] 食品の摂取順序による血糖上昇曲線下面積のちがいとその評価方法

    • Author(s)
      長田知佳子、今井佐恵子、梶山静夫
    • Organizer
      第51回日本栄養食糧学会近畿支部会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Research-status Report
  • [Presentation] 食品の摂取順序の違いによる高血糖および低血糖を起こす割合

    • Author(s)
      長田知佳子、梶山静夫、福井道明、小笹寧子、今井佐恵子
    • Organizer
      第11回日本栄養改善学会近畿支部会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Research-status Report
  • [Book] 元祖「食べ順」野菜から食べるおいしいレシピ集2014

    • Author(s)
      今井佐恵子
    • Total Pages
      160
    • Publisher
      新星出版社
    • Related Report
      2014 Research-status Report
  • [Book] 野菜から食べるおいしいレシピ集2014

    • Author(s)
      今井佐恵子
    • Total Pages
      159
    • Publisher
      新星出版社
    • Related Report
      2013 Research-status Report
  • [Book] 「野菜から食べるだけ」ですぐ5キロ減2013

    • Author(s)
      梶山静夫、今井佐恵子
    • Total Pages
      221
    • Publisher
      三笠書房
    • Related Report
      2013 Research-status Report
  • [Book] なぜ「食べる順番」は人をここまで健康にするのか2012

    • Author(s)
      梶山静夫、今井佐恵子
    • Total Pages
      192
    • Publisher
      三笠書房
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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