| Project/Area Number |
23500823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Fujita Health University |
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Principal Investigator |
IIDA Tadayuki 藤田保健衛生大学, 医学部, 講師 (50290549)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yasuhiro 藤田保健衛生大学, 医療科学部, 教授 (40176368)
INOUE Ken 島根大学, 医学部, 准教授 (40469036)
TAKANO Yu 熊本県立大学, 環境共生学部, 助教 (80405571)
HARADA Toshihide 県立広島大学, 保健福祉学部, 教授 (60181020)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抑うつ / 8-OHdG / ストレス / 月経 / 若年女性 / SDS / 8-OH-dG / Biopyrrin / セロトニン / TRAP-5b / 女性 / 抑うつ症状 / 月経周期 / エストロゲン |
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| Research Abstract |
This study aimed to clarify the association between depressive symptoms and a marker of DNA damage due to oxidative stress in young females. Since the menstrual cycle may confound or modify the association, depressive symptoms and urinary levels of 8-hydroxy-2' deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (21.6(0.8)) of a Japanese health science university were studied. The menstrual cycle was divided into 3 phases: menstrual (days 1 to 3 after the onset of menses): proliferative (13 to 15): and secretory (24 to 26). The menstrual cycle adjusted 8-OHdG level was significantly higher in those with depressive symptom than those without. The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance in all the menstrual cycle (0.73-0.81, all p<0.05). These results indicated the existence of oxidative stress in subjects with depressive symptom independent of the menstrual cycle.
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