Usefulness of central arterial presure response to dynamic exercise for the assessment of vascular endotherial function

• Project/Area Number: 23500840
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Wakayama Medical University
• Principal Investigator: MIYAI Nobuyuki 和歌山県立医科大学, 保健看護学部, 教授 (40295811)
• Co-Investigator(Renkei-kenkyūsha): ARITA Mikio 和歌山県立医科大学, 保健看護学部, 教授 (40168018) ; MIYASHITA Kazuhisa 和歌山県立医科大学, 医学部, 教授 (50124889) ; MORIOKA Ikuharu 和歌山県立医科大学, 保健看護部, 教授 (70264877) ; TERADA Kazufumi 天理大学, 体育学部, 准教授 (40454798) ; UTSUMI Miyoko 和歌山県立医科大学, 保健看護部, 教授 (00232877)
• Research Collaborator: TOMIDA Kotaro 和歌山大学, 経済学部, 准教授 (50197935) ; HATTORI Sonomi 和歌山県立医科大学, 保健看護部, 准教授 (00438285) ; MURE Kanae 和歌山県立医科大学, 医学部, 講師 (90268491)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 運動負荷試験 / 中心動脈圧波 / 動脈伸展性 / 血管内皮機能 / 動脈硬化 / 反射指標 / 反射指数

Research Abstract

In this study, we have demonstrated that the exaggerated responses of central arterial pressure and wave reflection markers during dynamic exercise are related to a state of structural and functional impairments of the vasculature in the early stages of hypertension. These results suggest that subclinical atherosclerosis may have a greater influence on vascular reactivity than on basal tone and hence could potentially be identified by an abnormal response of central arterial pressure to exercise even before clinical manifestation of atherosclerosis. In addition, an amplified wave reflection from periphery due to the vascular alterations, such as increased arterial stiffness and endothelial dysfunction, induces greater central aortic pressure and leads to the increase in overall left ventricular afterload. Thus, the central arterial pressure response to exercise may also be useful as an evaluation of hypertension-related risks of cardiovascular complications.

Research Products

• [Journal Article] Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors (2013)
  • Author(s): Miyai N, Shiozaki M, Yabu M, Utsumi M, Morioka I, Miyashita K, Arita M
  • Journal Title: Hypertens Res Volume: 36 Pages: 534-539
  • NAID: 10031189658
  • Peer Reviewed
• [Journal Article] Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors (2013)
  • Author(s): Miyai N, Shiozaki M, Yabu M, Utsumi M, Morioka I, Miyashita K, Arita M
  • Journal Title: Hypertension Research Volume: 24 Issue: 6 Pages: 534-539
  • DOI: 10.1038/hr.2012.215
  • NAID: 10031189658
  • Peer Reviewed
• [Presentation] Mean arterial pressure during submaximal exercise is associated with makers of subclinical atherosclerosis in prehypertension (2014)
  • Author(s): Miyai N, Shiozaki M, Uchikawa Y, Terada K, Tomida K, Utsumi M, Hattori S, Miyashita K, Arita M
  • Organizer: Joint Meeting of the 24th European Society of Hypertension& the 25th International Society of Hypertension
  • Place of Presentation: Athens, Greece
• [Presentation] 運動負荷に伴う中心動脈圧波の反射波成分の変化と左室壁肥厚との関連 (2014)
  • Author(s): 宮井信行、塩崎万起、寺田和史、冨田耕太郎、内川友起子、内海みよ子、服部園美、森岡郁晴、有田幹雄、宮下和久
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山市
• [Presentation] Central arterial blood pressure response to dynamic exercise is a useful marker of peripheral vasodilatory function in early stages of hypertension (2013)
  • Author(s): Miyai N, Shiozaki M, Uchikawa Y, Utsumi M, Tomida K, Hashizume T, Miyashita K, Arita M
  • Organizer: 23th Scientific Meeting of the European Society of Hypertension
  • Place of Presentation: Milan, Italy
• [Presentation] Exaggerated Blood Pressure Response and Delayed Blood Pressure Recovery Are Associated with Arterial Stiffness in Prehypertensive Subjects (2013)
  • Author(s): Miyai N, Idoue A, Hirata C, Takahashi M, Nagano S, Iwahara A, Hattori S, Buyo M, Hashizume T, Uematsu Y, Utsumi M, Shiba M, Miyashita K, Arita M
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 運動負荷試験による血圧変化に及ぼす動脈伸展性の低下の影響 (2012)
  • Author(s): 宮井信行, 塩崎万起, 内海みよ子, 内川友起子, 福元仁, 森岡郁晴, 有田幹雄, 武田眞太郎, 宮下和久
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋
• [Presentation] Central blood pressure response to exercise as an evaluation of left ventricular afterload in early stages of hypertension (2012)
  • Author(s): Miyai N, Shiozaki M, Kinjo Y, Uchikawa Y, Fukumoto J, Terada K, Tomida K, Miyashita K, Arita M
  • Organizer: 22nd Scientific Meeting of the European Society of Hypertension
  • Place of Presentation: London, UK
• [Presentation] 運動負荷試験による血圧変化に及ぼす動脈伸展性の低下の影響 (2012)
  • Author(s): 宮井信行、塩崎万起、内海みよ子、内川友起子、福元 仁、森岡郁晴、有田幹雄、武田眞太郎、宮下和久
  • Organizer: 第85回日本産業衛生学会、名古屋（名古屋国際会議場）、2012年5月31日
  • Place of Presentation: 名古屋
• [Presentation] 高血圧者における運動負荷時の橈骨動脈-大動脈脈圧比の変化と左室ストレスの評価 (2011)
  • Author(s): 宮井信行, 塩崎万起, 内川友起子, 藪 真悠子, 内海みよ子, 森岡郁晴, 宮下和久, 有田幹雄
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 栃木
• [Presentation] Relationship of blood pressure response to exercise with arterial stiffness and urinary albumin excretion in normal and early stages of hypertension (2011)
  • Author(s): Miyai N, Shiozaki M, Utsumi M, Morioka I, Miyashita K, Arita M
  • Organizer: American College of Cardiology 60th Annual Scientific Session
  • Place of Presentation: New Orleans, USA
• [Presentation] Relationship of Blood Pressure Response to Exercise with Arterial Stiffness and Urinary Albumin Excretion in Normal and Early Stages of Hypertension
  • Author(s): Nobuyuki Miyai
  • Organizer: 第60回米国心臓学会
  • Place of Presentation: アメリカ・ニューオリンズ
• [Presentation] 高血圧者における運動負荷時の橈骨動脈-大動脈脈圧比の変化と左室ストレスの評価
  • Author(s): 宮井信行
  • Organizer: 第回日本高血圧学会総会
  • Place of Presentation: 栃木・宇都宮