| Project/Area Number |
23500842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyushu University |
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Principal Investigator |
KISHIMOTO Hiro 九州大学, 医学(系)研究科(研究院), 研究員 (00596827)
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| Co-Investigator(Kenkyū-buntansha) |
二宮 利治 九州大学, 病院腎臓高血圧脳血管内科, 臨床助教 (30571765)
熊谷 秋三 九州大学, 健康科学センター, 教授 (80145193)
清原 裕 九州大学, 大学院・医学研究院環境医学分野, 教授 (80161602)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 身体組成 / 死亡 / 地域住民 / 前向き研究 / 心血管病発症 / 久山町研究 / コホート研究 / 疫学 |
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| Research Abstract |
The aims of the present study were to investigate the relationships of body composition (whole body fat-free mass[FFM] and fat mass[FM]) with the risk of cardiovascular disease and mortality in a prospective study of 2937 community-dwelling Japanese participants aged 40 years or older. First, we evaluated cross-sectionally the relationships between FFM (%FFM) and FM (%FM)per weight and the prevalence of cardiovascular disease. The prevalence of cardiovascular disease significantly decreased with higher the level of %FFM. Nonsignificant association was observed between %FM and the prevalence of cardiovascular disease. Next, we prospectively investigated the relationships between FFM index (FFM/height2, kg/m2) and age- and sex-adjusted and multivariable-adjusted all-cause and cause-specific death. As a result, FFM index was inversely associated with the risk of all-cause, cardiovascular, cancer, and respiratory death, independent other risk factors of cardiovascular disease.
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