| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We evaluated the relationships between the composition of free fatty acids (FFA) and metabolic parameters, including body fat distribution. The study subjects were 83 Japanese (46 men/37 women) who underwent 75g-OGTT. 24 fractions of serum FFA, lipids, and fat distribution by CT scanning were measured. Our data suggest that linoleic acid level was inversely correlated with accumulation of visceral fat in relation to a reduction of insulin resistance. We evaluated an original treadmill protocol "KEIO-SENIOR" which we developed for patients with diabetes who need exercise prescription. The study subjects were 43 Japanese. Based on our findings, we made an exercise prescription. After 6 months, we found significant weight reduction, decreased blood pressures and improvement of glycemic control. We followed 12 subjects for about 2 years. Our data suggest that the changes in linoleic acid level were inversely correlated with the changes in visceral fat in relation to insulin resistance.
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