| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the 6-year longitudinal study on non-diabetic Japanese, aged 25-60 years, glucose tolerance had improved in only 2 subjects, was unchanged in 347 and worsened in 41 in males, and 0,133 and 14, respectively, in females.
Baseline factors correlating significantly with status [No change = 0/Worsened = 1] in males were age, BMI, plasma glucose, TG, LDL-cholesterol, ALT, γ-GTP, HOMA-R, high-molecular-weight (HMW)-adiponectin levels. No correlations were observed with baseline smoking, alcohol consumption or exercise status.
Stepwise multiple regression analysis of [No change/Worsened] as a dependent variable revealed that baseline glucose (F= 51.2, r’= 0.300), HMW-adiponectin (F = 11.5, r’= -0.165) and age (F = 5.1, r’= 0.110) to show significant independent correlations in males (P< 0.0001, R2= 0.156).
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