Behavior modification program using longevity-associated mitochondrial DNA polymorphism data

• Project/Area Number: 23500859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Showa University
• Principal Investigator: KOKAZE Akatsuki 昭和大学, 医学部, 教授 (70271583)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
• Keywords: 遺伝子多型 / ミトコンドリアDNA / 遺伝的リスク / 生活習慣 / 行動変容 / 遺伝的リスク値 / 多型 / 喫煙習慣 / 飲酒習慣 / 緑茶飲用 / 脂質異常症 / 高血圧 / 推算糸球体濾過量 / ミトコンドリアDNA多型 / 長寿 / 交互作用

Research Abstract

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies the effects of alcohol consumption on hyper-LDL cholesterolemia, the effects of cigarette smoking on the risk of dyslipidemia, the effects of alcohol consumption or cigarette smoking on serum non-HDL cholesterol levels, the effects of green tea consumption on the risk of hypertension, the effects of alcohol consumption or green tea consumption on the estimated glomerular filtration rate, and the effects of alcohol consumption or coffee consumption on the clustering of cardiovascular risk factors. It is hoped that these findings will contribute to the establishment of personalized behavior modification programs for the prevention of lifestyle-related diseases.

Research Products

• [Journal Article] Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men : a cross-sectional study (2014)
  • Author(s): Ito T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Hoshino H, Takashima Y
  • Journal Title: Journal of Diabetes & Metabolic Disorders Volume: 13 Pages: 4-4
  • Peer Reviewed
• [Journal Article] Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men : a cross-sectional study (2014)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Hoshino H, Takashima Y
  • Journal Title: Journal of Physiological Anthropology Volume: 33 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study. (2014)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Hoshino H, Takashima Y.
  • Journal Title: Journal of Physiological Anthropology Volume: 33 Issue: 1 Pages: 1-1
  • DOI: 10.1186/1880-6805-33-1
  • Peer Reviewed
• [Journal Article] Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men: a cross-sectional study. (2014)
  • Author(s): Ito T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Hoshino H, Takashima Y.
  • Journal Title: Journal of Diabetes & Metabolic Disorders Volume: 13 Issue: 1 Pages: 4-4
  • DOI: 10.1186/2251-6581-13-4
  • Peer Reviewed
• [Journal Article] Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees : a cross-sectional study (2013)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Shirasawa T, Ochiai H, Hoshino H, Takashima Y
  • Journal Title: Journal of Negative Results in BioMedicine Volume: 12 Pages: 17-17
  • Peer Reviewed
• [Journal Article] Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees : a cross-sectional study (2013)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Hoshino H, Takashima Y
  • Journal Title: BMC Nephrology Volume: 14 Pages: 35-35
  • Peer Reviewed
• [Journal Article] Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study. (2013)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Shirasawa T, Ochiai H, Hoshino H, Takashima Y.
  • Journal Title: Journal of Negative Results in BioMedicine Volume: 12 Issue: 1 Pages: 17-17
  • DOI: 10.1186/1477-5751-12-17
  • Peer Reviewed
• [Journal Article] Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study (2013)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Hoshino H, Takashima Y
  • Journal Title: BMC Nephrology Volume: 14 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1471-2369-14-35
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men (2012)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Satoh M, Hashimoto M, Hoshino H, Takashima Y
  • Journal Title: Lipids in Health and Disease Volume: 11 Pages: 97-97
  • Peer Reviewed
• [Journal Article] Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and green tea consumption on risk of hypertension in middle-aged Japanese men (2012)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Saga N, Hoshino H, Takashima Y
  • Journal Title: Human Biology Volume: 84 Pages: 307-318
  • Peer Reviewed
• [Journal Article] Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men (2011)
  • Author(s): Kawamoto T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Ito T, Hoshino H, Takashima Y
  • Journal Title: Lipids in Health and Disease Volume: 10 Pages: 105-105
  • Peer Reviewed
• [Journal Article] Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men. (2011)
  • Author(s): Kawamoto T, Kokaze A, Ishikawa M, et al.
  • Journal Title: Lipids in Health and Disease Volume: 10 Pages: 105-105
  • Peer Reviewed
• [Presentation] 長寿関連ミトコンドリアDNA多型における緑茶飲用と推算糸球体濾過量との関係解析 (2014)
  • Author(s): 小風 暁, 石川 守, 苅田香苗, 吉田正雄, 大津忠弘, 落合裕隆, 白澤貴子, 南里妃名子, 星野祐美, 高島 豊
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 2014-01-25
• [Presentation] 長寿関連ミトコンドリアDNA 多型における飲酒習慣と推算糸球体濾過量との関係解析 (2013)
  • Author(s): 小風 暁, 石川 守, 苅田香苗, 吉田正雄, 大津忠弘, 落合裕隆, 白澤貴子, 星野祐美, 高島 豊
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2013-03-26
• [Presentation] 長寿関連ミトコンドリアDNA多型における飲酒習慣と推算糸球体濾過量との関係解析 (2013)
  • Author(s): 小風 暁、石川 守、苅田香苗、吉田正雄、大津忠弘、落合裕隆、白澤貴子、星野祐美、高島 豊
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 石川県金沢市
• [Presentation] 長寿関連ミトコンドリアDNA 多型における飲酒習慣, 喫煙習慣とnon-HDL コレステロール濃度との関係解析 (2012)
  • Author(s): 小風 暁, 大津忠弘, 落合裕隆, 白澤貴子
  • Organizer: 第59回昭和医学会総会
  • Place of Presentation: 品川区
  • Year and Date: 2012-12-01
• [Presentation] 長寿関連ミトコンドリアDNA 多型における喫煙習慣と脂質異常症リスクとの関係解析 (2012)
  • Author(s): 小風 暁, 石川 守, 苅田香苗, 吉田正雄, 島田直樹, 大津忠弘, 白澤貴子, 落合裕隆, 星野祐美, 高島 豊
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都市
  • Year and Date: 2012-03-25
• [Presentation] 長寿関連ミトコンドリアDNA多型における喫煙習慣と脂質異常症リスクとの関連解析 (2012)
  • Author(s): 小風暁、石川守、苅田香苗、他7名．
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都市
• [Presentation] 長寿関連ミトコンドリアDNA多型と飲酒習慣との高LDLコレステロール血症リスクへの影響 (2011)
  • Author(s): 河本輝敬, 小風 暁, 島田直樹, 大津忠弘, 白澤貴子, 落合裕隆
  • Organizer: 第58回昭和医学会総会
  • Place of Presentation: 品川区
  • Year and Date: 2011-11-26
• [Presentation] 長寿関連ミトコンドリアDNA多型における飲酒習慣、喫煙習慣とnon-HDLコレステロール濃度との関係解析
  • Author(s): 小風 暁、大津忠弘、落合裕隆、白澤貴子
  • Organizer: 第59回昭和医学会総会
  • Place of Presentation: 東京都品川区