Associations of serum 25-hydroxyvitamin D concentration with objectively measured physical activity and VO2max in Japanese adults

• Project/Area Number: 23500864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Waseda University
• Principal Investigator: CAO Zhen-Bo 早稲田大学, スポーツ科学学術院, 助教 (60571734)
• Co-Investigator(Kenkyū-buntansha): HIGUCHI Mitsuru 早稲田大学, スポーツ科学学術院, 教授 (20192289) ; TABATA Izumi 立命館大学, スポーツ健康科学部, 教授 (20188402) ; ISHIMI Yoshiko 独立行政法人国立健康・栄養研究所, 部長 (50154159)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ビタミンD / 心肺体力 / 最大酸素摂取量 / 身体活動 / 体力 / 栄養 / ２５（OH)D / 25(OH)D / 筋力 / 身体活動量 / 運動

Research Abstract

Vitamin D deficiency is highly prevalent in our study sample.In a cross-sectional study, we found that objectively measured physical activity and VO2max are independently and positively related to serum vitamin D status. Twelve months supplementation significantly improved 25(OH)D status in the vitamin D group compared to no changes in the Placebo group. However, the increase in 25(OH)D concentration in the vitmin D group did not result in signifi cant increases in VO2max.

Research Products

• [Journal Article] Association between serum 25-hydroxyvitamin D and inflammatory cytokines in healthy adults (2014)
  • Author(s): Sun X, Cao ZB, Zhang Y, Ishimi Y, Tabata I, Higuchi M
  • Journal Title: Nutrients Volume: 6 Pages: 221-230
• [Journal Article] Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men (2014)
  • Author(s): Tanisawa K, Ito T, Sun XM, Cao ZB, Sakamoto S, Tanaka M, Higuchi M
  • Journal Title: Physiol Genomics Volume: 46(6) Pages: 207-15
• [Journal Article] Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels (2014)
  • Author(s): Tanisawa K, Taniguchi H, Sun XM, Ito T, Cao ZB, Sakamoto S, Higuchi M
  • Journal Title: Metabolism Volume: 63(4) Pages: 574-83
• [Journal Article] Association between serum 25-hydroxyvitamin D and inflammatory cytokines in healthy adults. (2014)
  • Author(s): Sun X, Cao ZB, Zhang Y, Ishimi Y, Tabata I, Higuchi M.
  • Journal Title: Nutrients. Volume: 6 Issue: 1 Pages: 221-230
  • DOI: 10.3390/nu6010221
  • Peer Reviewed
• [Journal Article] Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men. (2014)
  • Author(s): Tanisawa K, Ito T, Sun XM, Cao ZB, Sakamoto S, Tanaka M, Higuchi M.
  • Journal Title: Physiol Genomics. Volume: 46 Issue: 6 Pages: 207-215
  • DOI: 10.1152/physiolgenomics.00182.2013
  • Peer Reviewed / Open Access
• [Journal Article] Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels (2014)
  • Author(s): Tanisawa K, Taniguchi H, Sun X, Ito T, Cao ZB, Sakamoto S, Higuchi M.
  • Journal Title: Metabolism Volume: 63(4) Issue: 4 Pages: 574-583
  • DOI: 10.1016/j.metabol.2014.01.005
  • Peer Reviewed
• [Journal Article] Steps per day required for meeting physical activity guidelines in Japanese adults. (2014)
  • Author(s): Cao ZB, Oh T, Miyatake N, Tsushita K, Higuchi M, Tabata I.
  • Journal Title: Journal of Physical Activity & Health. Volume: in press
  • Peer Reviewed
• [Journal Article] Steps per day required for meeting physical activity guidelines in Japanese adults (2013)
  • Author(s): Cao ZB, Oh T, Miyatake N, Tsushita K, Higuchi M, Tabata I
  • Journal Title: Journal of Physical Activity & Health Volume: (In press)
• [Journal Article] Does Cardiorespiratory Fitness Modify the Association between Birth Weight and Insulin Resistance in Adult Life? (2013)
  • Author(s): Aoyama T, Tsushita K, Miyatake N, Numata T, Miyachi M, Tabata I, Cao ZB, Sakamoto S, Higuchi M
  • Journal Title: PLOS ONE Volume: 8(9)
• [Journal Article] Does Cardiorespiratory Fitness Modify the Association between Birth Weight and Insulin Resistance in Adult Life? (2013)
  • Author(s): Tomoko Aoyama, Kazuyo Tsushita, Nobuyuki Miyatake, Takeyuki Numata, Motohiko Miyachi, Izumi Tabata, Zhen-Bo Cao, Shizuo Sakamoto, Mitsuru Higuchi
  • Journal Title: PLOS ONE Volume: 17;8(9) Issue: 9 Pages: e73967-e73967
  • DOI: 10.1371/journal.pone.0073967
  • Peer Reviewed
• [Journal Article] Prediction of maximal oxygen uptake from a 3-minute walk, gender, age, and body composition. (2013)
  • Author(s): Cao ZB, et al.
  • Journal Title: Journal of Physical Activity & Health Volume: 10(2) Pages: 280-287
  • Peer Reviewed
• [Journal Article] Association between dietary intake of micronutrients and cardiorespiratory fitness in Japanese men. (2012)
  • Author(s): Cao ZB, et al.
  • Journal Title: Journal of Nutritional Science Volume: 1
  • DOI: 10.1017/jns.2012.16
  • Peer Reviewed
• [Journal Article] Associations between muscular fitness and metabolic syndrome: Cross-sectional study of Japanese women and men. (2012)
  • Author(s): Tanaka A, Cao ZB, Saito Y, Kobori Y, Higuchi M.
  • Journal Title: Health Volume: 4 (10) Issue: 10 Pages: 838-844
  • DOI: 10.4236/health.2012.410129
  • Peer Reviewed
• [Journal Article] Prediction of maximal oxygen uptake from a 3-minute walk, gender, age, and body composition (2011)
  • Author(s): Cao ZB, et al.
  • Journal Title: Journal of Physical Activity and Health Volume: in press
  • Peer Reviewed
• [Presentation] Association Between Serum 25-hydroxy Vitamin D And Inflammatory Cytokines : Impact Of Physical Activity (2013)
  • Author(s): Sun XM, Zhang Y, Cao ZB, Higuchi M
  • Organizer: Medicine & Science in Sports & Exercise
• [Presentation] Association between objectively measured physical activity and serum 25-hydroxyvitamin D concentration in Japanese adults (2013)
  • Author(s): Cao ZB, Sun XM, Zhang YP, Ishimi, Y, Tabata I, Higuchi M
  • Organizer: 18th Annual Congress of the ECSS
  • Place of Presentation: Barcelona, Spain
• [Presentation] 健康成人における血中ビタミンD 濃度と筋量および筋力との関連 (2013)
  • Author(s): 曹振波, 孫暁敏, 田畑泉, 樋口満
  • Organizer: 日本体育学会第64回大会抄録集
• [Presentation] Association Between Serum 25-hydroxy Vitamin D And Inflammatory Cytokines: Impact Of Physical Activity (2013)
  • Author(s): Sun XM, Zhang Y, Cao ZB, Higuchi M.
  • Organizer: 60th Annual Meeting of the American College of sports Medicine
  • Place of Presentation: Indianapolis
• [Presentation] Association between objectively measured physical activity and serum 25-hydroxyvitamin D concentration in Japanese adults. (2013)
  • Author(s): Cao ZB, Sun XM, Zhang YP, Ishimi, Y, Tabata I, Higuchi M.
  • Organizer: 18th Annual Congress of the ECSS.
  • Place of Presentation: Barcelona
• [Presentation] 健康成人における血中ビタミンD 濃度と筋量および筋力との関連. (2013)
  • Author(s): 曹振波, 孫暁敏, 田畑泉, 樋口満.
  • Organizer: 日本体育学会第64回大会
  • Place of Presentation: 立命館大学
• [Presentation] Association between objectively measured physical activity and serum 25-hydroxyvitamin D concentration in Japanese adults. (2013)
  • Author(s): Cao ZB, Sun XM, Zhang YP, Ishimi, Y, Tabata, I, Higuchi M.
  • Organizer: 18th Annual Congress of the ECSS
  • Place of Presentation: Barcelona, Spain
• [Presentation] Association between serum 25-hydroxyvitamin D and inflammatory markers: impact of physical activity. (2012)
  • Author(s): Sun XM, Zhang YP, Cao ZB, Higuchi M.
  • Organizer: 11th Annual Conference for SCSEPF
  • Place of Presentation: Shanghai, China
• [Presentation] 大学ハンドボール選手の血中ビタミンD濃度と全身持久力との関連 (2012)
  • Author(s): 曹 振波ほか
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜市
• [Presentation] Serum Vitamin D Status in College American Football Players. (2012)
  • Author(s): Sun XM, Cao ZB, Higuchi M.
  • Organizer: 20th International Congress on Sports Sciences for Students
  • Place of Presentation: Budapest, Hungary
• [Presentation] 身体活動ガイドラインに基づく1日平均歩数の基準値の検討 (2011)
  • Author(s): 曹 振波
  • Organizer: 日本体育学会第62回大会
  • Place of Presentation: 鹿屋体育大学