Induction of neurogenesis from endogenous neural precursors in the adult brain after stroke by long-term voluntary execise
| Project/Area Number |
23500866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kinki University |
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Principal Investigator |
NIWA Atsuko 近畿大学, 医学部, 講師 (60122082)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Hideo 近畿大学, 医学部, 教授 (60335627)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASAKA Naoto 山口大学, 医学系研究科, 准教授 (80368290)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脳血管障害 / 神経新生 / 血管新生 / 運動 / 神経幹細胞 / 骨髄細胞 / 再生環境 / 炎症 / 脳卒中 / 運動習慣 / 神経栄養因子 / 視床下部 / ホメオスタシス / 神経再生 / NO / 調節因子 / 血管内皮前駆細胞 |
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| Research Abstract |
Long-term voluntary exercise (EX) decreased stroke events in stroke-prone genetically hypertensive rats (SHRSP). Volume of cerebral lesion was also reduced and neural defects were improved, resulting in prolonged life span in post-stroke EX rats. Possible strategies for regenerating damaged central nervous system;(1)activation of endogenous neural stem (progenitor) cells (NSC) (2)modification of microenvironment surrounding stroke lesion for their development and differentiation (3)enhanced migration of endothelial progenitor cells (EPC) and NSC. We found that Ex increased the number of NSC and EPC, and enhaced their differentiation in lateral venticle and cerebral lesion. Cell senescence in bone marrow was suppressed by EX. Production of inflammatory factors in plasma, CSF and lesion was also decreased in EX rats. The improvement may depend on NO production. Nerve growth factors and chemokine including BDNF, FGF, EGF, IGF-1 and CXCL12 were produced in early phase after stroke in EX.
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Report
(4 results)
Research Products
(8 results)
