Investigation of food constituents with unique functions effective on lifestyle diseases

• Project/Area Number: 23500941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Senri Kinran University
• Principal Investigator: HINUMA Shuji 千里金蘭大学, 生活科学部, 教授 (60550522)
• Co-Investigator(Kenkyū-buntansha): NAGATA Kumiko 千里金蘭大学, 生活科学部・食物栄養学科, 教授 (90068502)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食品機能成分 / マクロファージ / クルクミン / リポソーム / 増殖抑制 / フラボノイド

Outline of Final Research Achievements

We screened food constituents suppressing macrophages. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We eventually succeeded in preparing liposomes with sufficient amounts of curcumin to suppress macrophages by incorporating a complex of curcumin and bovine serum albumin.After intraperitoneal administration of the liposomes containing curcumin into mice, these were incorporated mainly by macrophages, and as a result macropahge function was suppressed. Our study indicates that the liposomes containing curcumin are safe and useful for the selective suppression of macrophages.

Research Products

• [Presentation] Suppression of macrophage function by liposome containing curcumin (2014)
  • Author(s): 日沼 州司
  • Organizer: 1st series of Indian Scientists Association in Japan-Lectures
  • Place of Presentation: 筑波 二宮セミナーハウス
  • Invited
• [Presentation] クルクミン内包リポソームのマクロファージ枯渇効果に関する研究 (2013)
  • Author(s): 天野 千絵, 岩下 真輝, 峯松 秀希, 北川 寛之, 平松 由衣, 大谷 敬亨, 平井 政彦, 安達昌城, 日沼 州司
  • Organizer: 第29回日本ＤＤＳ学会学術集会
  • Place of Presentation: 京都テルサ
• [Presentation] 高濃度クロドロネート内包リポソームのマウス大腿骨由来骨髄性マクロファージにおける増殖抑制効果
  • Author(s): 峯松秀希、岩下真輝、北川寛之、天野千絵、平松由衣、大谷敬亨、平井政彦、大家一典、日沼州司、五十嵐貢一
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜
• [Patent(Industrial Property Rights)] マクロファージ機能抑制及び/又は癌細胞増殖抑制 (2012)
  • Inventor(s): 日沼州司
  • Industrial Property Rights Holder: 日沼州司
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-169173
  • Filing Date: 2012