| Project/Area Number |
23500951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEI Asuka 神奈川科学アカデミー, アンチエイジングプロジェクト, 研究員 (40514112)
SHINOZAKI Fumika 神奈川科学アカデミー, アンチエイジングプロジェクト, 研究員 (00359647)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 食物繊維 / 腸内細菌叢 / DNAマイクロアレイ / ラット / 遺伝子発現 / 生活習慣病 |
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| Research Abstract |
In 40-week-old male wister rats reared for one week with food containing 10%, 5%, and 2% cellulose as dietary fiber, suppression of lipid synthesis system was seen in the gene expression of the liver. Although , in regard to lipid levels in liver, the total cholesterol level was seen to significantly increase by increasing the intake of cellulose. Also, a significant variation in the intestinal flora due to the variation of dietary fiber intake was detected. The observation of the change in gastrointestinal gene expression due to the amount of cellulose intake is the report which shows that cellulose that is not absorbed into the body has a function to indirectly control the gene expression in the body.
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