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Influence of maternal intake of n-3 fatty acid on fatty acid transport of fetal blood brain barrier

Research Project

Project/Area Number 23500956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionYamaguchi University

Principal Investigator

TOKUDA NOBUKO  山口大学, 医学(系)研究科(研究院), 教授 (70227578)

Co-Investigator(Kenkyū-buntansha) OWADA Yuji  山口大学, 大学院・医学系研究科, 教授 (20292211)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脂肪酸 / 胎盤 / 血管 / 血液脳関門 / 情動行動 / 脳 / 神経 / オリゴデンドロサイト / 脂肪酸結合タンパク質 / n-3系脂肪酸 / FABP / ストローマ細胞 / 血管内皮
Research Abstract

Epidemiological studies suggest that maternal dietary poor intake of n-3 and some fatty acids may trigger certain mental disorders of fetus. However, the molecular basis of their actions is still unknown. Our findings show that fatty acid binding protein 3 (FABP3) controls fatty acid trafficking in mouse placenta and the transport is important for fetal development. FABP3 also regulates cognitive function and anxiety behaviors. In mouse brain, FABP5 and FABP7 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (104 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (72 results) Remarks (5 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 4 results)

  • [Journal Article] Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice2014

    • Author(s)
      Suzuki, J., Owada, Y.
    • Journal Title

      Neurosci Res

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperlocomotor activity and stress vulnerability during adulthood induced by social isolation after early weaning are prevented by voluntary running exercise before normal weaning period.2014

    • Author(s)
      Ishikawa, J., Ogawa, Y., Owada, Y. and Ishikawa A.
    • Journal Title

      Behavior Brain Res

      Volume: in press Pages: 197-206

    • DOI

      10.1016/j.bbr.2014.02.007

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] nvolvement of bone marrow-derived vascular progenitor cells in neovascularization during follicular development in mice.2014

    • Author(s)
      Kizuka-Shibuya, F., Tokuda, N., Takagi, K., Adachi, Y., Lee, L., Tamura, I., Maekawa, R., Tamura, H., Suzuki, T., Owada, Y. and Sugino N.
    • Journal Title

      J Ovarian Res

      Volume: 7 Issue: 1 Pages: 10-10

    • DOI

      10.1186/1757-2215-7-10

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans.2014

    • Author(s)
      Nomura, S., Fujii, M., Inoue, T., He, Y., Maruta, Y., Koizumi, H., Suehiro, E., Imoto, H., Ishihara, H., Oka, F., Matsumoto, M.,Owada, Y., Yamakawa, T. and Suzuki, M.
    • Journal Title

      Epilepsia

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice.2014

    • Author(s)
      Suzuki, J., Oshima, T., Yoshida, N., Kimura, R., Takata, Y., Owada, Y., Kobayashi, T. and Osumi, N.
    • Journal Title

      Neurosci Res

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マウス脳からのニューロン及びアストロサイトの初代培養法2014

    • Author(s)
      香川慶輝、Majid Ebrahimi、大和田祐二
    • Journal Title

      山口医学

      Volume: 63 Pages: 89-91

    • NAID

      130004897873

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatty acid binding protein 7 as a marker for glioma stem cells.2013

    • Author(s)
      Morihiro, Y., Yasumoto, Y., Koshy, VL., Sadahiro, H., Uchida, T., Inamura, A., Sharifi, K., Ideguchi, M., Nomura, S., Tokuda, N., Kashiwabara, S., Ishii, A., Ikeda, E., Owada , Y. * and Suzuki, M. (* corresp. author)
    • Journal Title

      Pathol Int

      Volume: 63 Issue: 11 Pages: 546-553

    • DOI

      10.1111/pin.12109

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells2013

    • Author(s)
      Sharifi K, Yoshikawa
    • Journal Title

      Cell and Tissue Research

      Volume: 354 Issue: 3 Pages: 683-695

    • DOI

      10.1007/s00441-013-1730-7

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of hypothermia therapy in neonatal mice on the cortical laminar disruption following ischemic injury in neonatal mice.2013

    • Author(s)
      Kida, H., Nomura, S., Shinoyama, M., Ideguchi, M., Owada, Y. and Suzuki, M.
    • Journal Title

      PLos One

      Volume: 8 Issue: 7 Pages: e68877-e68877

    • DOI

      10.1371/journal.pone.0068877

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of highly invasive glioma stem cells in a mouse xenograft model.2013

    • Author(s)
      Sadahiro, H., Yoshikawa, K., Ideguchi, M., Kajiwara, K., Ishii, A., Ikeda, E., Owada, Y., Yasumoto, Y. and Suzuki, M.
    • Journal Title

      Brain Tumor Pathol

      Volume: 31 Issue: 2 Pages: 77-84

    • DOI

      10.1007/s10014-013-0149-x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooling treatment transiently increases the permeability of brain capillary endothelial cells through translocation of claudin-5.2013

    • Author(s)
      Inamura, A., Adachi, Y., Inoue, T., He, Y., Tokuda, N., Nawata, T., Shirao, S., Nomura, S., Fujii, M., Ikeda, E., Owada, Y. * and Suzuki, M. (* corresp. author)
    • Journal Title

      Neurochem Res

      Volume: 38 Issue: 8 Pages: 1641-1647

    • DOI

      10.1007/s11064-013-1066-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective.2013

    • Author(s)
      Yeting He
    • Journal Title

      Brain Res

      Volume: 1497 Pages: 53-60

    • DOI

      10.1016/j.brainres.2012.11.041

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal-type FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions.2012

    • Author(s)
      Miyake, T., Ogawa, E., Mikoshiba, A., Kobayashi, A., Hosoe, H., Kashiwabara, S., Uhara, H., Owada, Y. and Okuyama, R.
    • Journal Title

      J Dermatol Sci

      Volume: 68 Issue: 3 Pages: 199-202

    • DOI

      10.1016/j.jdermsci.2012.09.002

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene.2012

    • Author(s)
      Sugawara T. et al.
    • Journal Title

      Experimental Dermatology

      Volume: Vol.21 Issue: 7 Pages: 543-546

    • DOI

      10.1111/j.1600-0625.2012.01514.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of bone marrow-derived vascular progenitor cells in neovascularization during the corpus luteum formation in mice.2012

    • Author(s)
      Kizuka, F., Tokuda, N., Takagi, K., Adachi, Y., Lee, L, Tamura, I., Maekawa, R., Taketani, T., Tamura, H., Suzuki, T., Owada, Y. and Sugino, N.
    • Journal Title

      Biol Reprod

      Volume: 87 Issue: 3 Pages: 1-7

    • DOI

      10.1095/biolreprod.112.099960

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells.2012

    • Author(s)
      Adachi, Y., Hiramatsu, S., Tokuda, N., Sharifi, K., Ebrahimi, M, Islam, A, Kagawa, Y., Koshy, LV., Sawada, T., Hamano, K. and Owada, Y.
    • Journal Title

      Histochem Cell Biol.

      Volume: 138 Issue: 3 Pages: 397-406

    • DOI

      10.1007/s00418-012-0963-y

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse.2012

    • Author(s)
      Miho Matsumata, Nobuyuki Sakayori, Motoko Maekawa, Yuji Owada, Takeo Yoshikawa, Noriko Osumi
    • Journal Title

      Stem Cells

      Volume: 30(7) Issue: 7 Pages: 1532-1543

    • DOI

      10.1002/stem.1124

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脂肪酸結合タンパク質 7 型2012

    • Author(s)
      徳田信子, 大和田祐二
    • Journal Title

      脳科学辞典, 脳科学辞典編集委員会編

    • URL

      http://bsd.neuroinf.jp/wiki/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous magnetic stimulation reduces rat chronic pain via activation of the supra-spinal descending pathway.2012

    • Author(s)
      Shiiba, S., Yamamoto, S., Sasaki, H., Nishi, M., Ishikawa, K., Yasuda, S., Tokuda, N., Nakanishi, O. and Ishikawa, T.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 32 Issue: 2 Pages: 245-253

    • DOI

      10.1007/s10571-011-9756-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions2011

    • Author(s)
      Fujii M, et al
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 3 Pages: 489-493

    • DOI

      10.1111/j.1528-1167.2011.03388.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation2011

    • Author(s)
      Sharifi K, Maekawa M, Yoshikawa T
    • Journal Title

      Histochem Cell Biol

      Volume: 136 Issue: 5 Pages: 501-513

    • DOI

      10.1007/s00418-011-0865-4

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies RNF213 as the first Moyamoya disease gene2011

    • Author(s)
      Kamada F, et al
    • Journal Title

      J Hum Genet

      Volume: 56(1) Issue: 1 Pages: 34-40

    • DOI

      10.1038/jhg.2010.132

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies RNF213 as the first Moyamoya disease gene.2011

    • Author(s)
      Ogawa, E. *, Owada, Y. *, Ikawa, S., Adachi, Y., Egawa, T., Nemoto, K., Suzuki, K., Hishinuma, T., Kawashima, H., Kondo, H., Muto, M., Aiba, S. and Okuyama, R.(* equally contributed)
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 604-612

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 帯状皮質の脂肪酸結合蛋白質は GABA 作動性ニューロン調節を介して神経可塑性に関与する2014

    • Author(s)
      山本由似, 徳田信子, 大和田祐二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市, 自治医科大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮質の脂肪酸結合蛋白質はGABA作動性ニューロン調節を介して神経可塑性に関与する2014

    • Author(s)
      山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学 (栃木県下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳型脂肪酸結合蛋白質(FABP7)によるエピジェネティックな遺伝子発現制御2014

    • Author(s)
      香川慶輝、大和田祐二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学 (栃木県下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FABP3 deficiency in mouse placenta impaired fatty acid transport form mother to fetus.2014

    • Author(s)
      Islam, A., Sharifi, K., Ebrahimi, M., Kagawa, Y., Sawada, T., Yamamoto, Y., Yasumoto, Y., Miyazaki, H., Suzuki, R. and Owada, Y.
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学 (栃木県下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経膠腫幹細胞におけるFABP7およびFASNの役割2014

    • Author(s)
      安本有希、貞廣浩和、内田智之、鈴木倫保、池田栄二、大和田祐二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学 (栃木県下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Kupffer細胞における脂肪酸結合蛋白質(FABP7)の機能2014

    • Author(s)
      宮崎啓史、澤田知夫、河村沙樹、児玉孝憲、大和田祐二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学 (栃木県下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FABP3は介在神経のGAD67発現を調節する2014

    • Author(s)
      山本由似、福永浩司、大和田祐二
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学 (熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FABP3は帯状皮質神経細胞におけるGABAシグナルを調節する2014

    • Author(s)
      山本由似、福永浩司、大和田祐二
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors2013

    • Author(s)
      Yamamoto, Y., Tokuda, N., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      USA, San Diego, San Diego Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7-deficiency altered membrane lipid raft formation in astrocytes2013

    • Author(s)
      Kagawa, Y., Tokuda, N., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      USA, San Diego, San Diego Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] Fatty acid-binding protein 7 (FABP7) regulates lipid raft formation in astrocytes2013

    • Author(s)
      Kagawa, Y., Tokuda, N., Owada, Y.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市, パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Fatty acid-binding protein controls lipid raft formation in astrocytes2013

    • Author(s)
      Kagawa, Y., Tokuda, N., Owada Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市, 国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuronal plasticity is regulated by glial fatty acid binding protein (FABP7)2013

    • Author(s)
      Ebrahimi, M., Tokuda, N., Owada, Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市, 国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪酸結合蛋白質 FABP3 欠損マウスにおける情動行動とシグナル伝達異常2013

    • Author(s)
      山本由似, 徳田信子, 大和田祐二
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松市, サンポートホール高松・かがわ国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7 regulates LPS-induced TNF- α production through lipid raft formation in the astrocytes2013

    • Author(s)
      Kagawa, Y., Tokuda, N., Owada, Y.
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松市, サンポートホール高松・かがわ国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝 Kupffer 細胞における脂肪酸結合蛋白質( FABP7 )の発現と貪食能への関与2013

    • Author(s)
      宮崎啓史, 徳田信子, 大和田祐二
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松市, サンポートホール高松・かがわ国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経膠腫幹細胞における FABP7 の発現について2013

    • Author(s)
      安本有希, 徳田信子, 大和田祐二
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松市, サンポートホール高松・かがわ国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7 as a regulator of reactive astrocyte proliferation2013

    • Author(s)
      Hara, T., Tokuda N., Owada, Y.
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松市, サンポートホール高松・かがわ国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7 is involved in epigenetic modification in astrocytes.2013

    • Author(s)
      Kagawa, Y., Yasumoto, Y., Sharifi, K., Ebrahimi, M., Islam, A., Miyazaki, H., Kawamura, S., Yamamoto, Y., Yoshikawa, T., Kogo, H., Sato, S., Sugino, N., Fujimoto, T., Owada, Y.
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors.2013

    • Author(s)
      Yamamoto, Y., Sharifi, K., Islam, A., Ebrahimi, M., Kagawa, Y., Yasumoto, Y.,Miyazaki, H., Kawamura, S., Sawada, T., Tokuda, N., Fukunaga, K., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FABP7-deficiency altered membrane lipid raft formation in astrocytes.2013

    • Author(s)
      Kagawa, Y., Ebrahimi, M., Sharifi, K., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto, Y., Sawada, T., Tokuda, N., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression and function of fatty acid binding protein 7 in glioma stem cells.2013

    • Author(s)
      Yasumoto, Y., Sadahiro, H., Sharifi, K., Kagawa, Y., Ebrahimi, M., Islam, A.,Miyazaki, H., Kawamura, S., Yamamoto, Y., Sawada, T., Suzuki, M., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] FABP7 is expressed in astrocytes and regulates the excitatory synapse formation in mouse cerebral cortex.2013

    • Author(s)
      Ebrahimi, M., Sharifi, K., Kagawa, Y., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto, Y., Sawada, T., Yoshikawa, T., Owada, Y.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質FABP3による情動・認知行動調節メカニズム2013

    • Author(s)
      山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
    • Organizer
      日本解剖学会第68回中国・四国支部学術集会
    • Place of Presentation
      鳥取大学医学部 (鳥取県米子市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝Kupffer細胞の貪食能やサイトカイン産生に脂肪酸結合タンパク質FABP7が関与する2013

    • Author(s)
      河村沙樹、宮崎啓史、澤田知夫、大和田祐二
    • Organizer
      日本解剖学会第68回中国・四国支部学術集会
    • Place of Presentation
      鳥取大学医学部 (鳥取県米子市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fatty acid-binding protein 7 (FABP7) regulates lipid raft formation in astrocytes.2013

    • Author(s)
      Kagawa, Y., Ebrahimi, M., Sharifi, K., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto, Y., Sawada, T., Tokuda, T., Kogo, H., Fujimoto, T., Yoshikawa, T., Owada, Y.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳型脂肪酸結合蛋白質 (FABP7)は脂質ラフト形成を制御する2013

    • Author(s)
      香川慶輝、Ebrahimi Majid、Sharifi Kazem、安本有希、宮崎啓史、Islam Ariful、 山本由似、河村沙樹、原伯徳、澤田知夫、大和田祐二
    • Organizer
      第119回山口大学医学会学術講演会
    • Place of Presentation
      山口大学医学部 (山口県宇部市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質FABP7によるマウスKupffer細胞の機能制御2013

    • Author(s)
      河村沙樹、宮崎啓史、澤田知夫、大和田祐二
    • Organizer
      日本比較免疫学会第25回学術集会
    • Place of Presentation
      岡山理科大学 (岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fatty acid binding protein 3 (FABP3)-knock-out induced cognitive dysfunction and anxiety phenotype.2013

    • Author(s)
      Yamamoto, Y., Owada, Y., Fukunaga, K.
    • Organizer
      第11回世界生物学的精神医学会国際会議
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質FABP3欠損マウスにおける認知機能及び情動行動異常の神経機序2013

    • Author(s)
      山本由似、福永浩司、大和田祐二
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fatty acid-binding protein controls lipid raft formation in astrocytes.2013

    • Author(s)
      Kagawa, Y., Ebrahimi, M., Sharifi, K., Miyazaki, H., Yasumoto, Y., Sawada, T., Tokuda, N., Kobayashi, S., Kogo, H., Fujimoto, T., Yoshikawa, T., Owada Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuronal plasticity is regulated by glial fatty acid binding protein (FABP7)2013

    • Author(s)
      Ebrahimi, M., Sharifi, K., Kagawa, Y., Yamamoto, Y., Islam, A., Yasumoto, Y., Miyazaki, H., Hara, T., Sawada, T., Tokuda, N., Yoshikawa, T., Owada, Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体恒常性の仕組みの解明と医学への応用-精神疾患を理解するための脂肪酸結合タンパク質研究2013

    • Author(s)
      山本由似、大和田祐二
    • Organizer
      山口大学研究推進体「ストレス」成果報告シンポジウム
    • Place of Presentation
      山口大学医学部(宇部)
    • Related Report
      2012 Research-status Report
  • [Presentation] シグナル伝達と情動行動への脂肪酸結合蛋白質 FABP3 の関与2013

    • Author(s)
      山本由似、大和田祐二、福永浩司
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP7 as a regulator of reactive astrocyte proliferation.2013

    • Author(s)
      Hara, T., Sharifi, K., Ebrahimi, M., Kagawa Y., Yasumoto, Y., Miyazaki H., Islam, A., Sawada, T., Tokuda N., Owada, Y.
    • Organizer
      第118回日本解剖学会総会・全国学術総会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経膠腫幹細胞におけるFABP7の発現について2013

    • Author(s)
      安本有希、Linda Koshy Vaidyan、貞廣浩和、徳田信子、澤田知夫、鈴木倫保、大和田祐二
    • Organizer
      第118回日本解剖学会総会・全国学術総会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝Kupffer細胞における脂肪酸結合蛋白質(FABP7)の発現と貪食能への関与2013

    • Author(s)
      宮崎啓史、澤田知夫、徳田信子、安達泰弘、大和田祐二
    • Organizer
      第118回日本解剖学会総会・全国学術総会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP7 regulates LPS-induced TNF-α production through lipid raft formation in the astrocytes2013

    • Author(s)
      Kagawa, Y., Adachi, Y., Tokuda, N., Kobayashi, S., Fujimioto, T., Yoshikawa, T., Owada, Y.
    • Organizer
      第118回日本解剖学会総会・全国学術総会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質 FABP3 欠損マウスにおける情動行動とシグナル伝達異常2013

    • Author(s)
      山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
    • Organizer
      第118回日本解剖学会総会・全国学術総会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP5 and FABP7 as novel markers and biological regulators for oligo- dendrocyte lineage2012

    • Author(s)
      Sharifi, K., Tokuda, N., Owada, Y.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市, 福岡国際会議場・マリンメッセ福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Control of neuronal dendritic formation by brain-type fatty acid binding protein (FABP7)2012

    • Author(s)
      Ebrahimi, M., Tokuda, N., Owada, Y.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      USA, New Orleans, Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] Fatty acid-binding protein 7(FABP7) regulates LPS-induced TNF- α production in astrocytes2012

    • Author(s)
      Kagawa, Y., Tokuda, N., Owada, Y.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      USA, New Orleans, Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] Fatty acid binding protein3 (FABP3) as a cellular regulator of fatty acid transport from mother to fetus in rodent placenta. Islam2012

    • Author(s)
      A., Tokuda, N., Owada, Y.
    • Organizer
      International Federation of Placenta Association (IFPA) 2012 congress
    • Place of Presentation
      広島市, 広島国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP5 and FABP7; novel markers in oligodendrocyte lineage2012

    • Author(s)
      Sharifi, K., Tokuda, N., Owada, Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市, 名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] アストロサイトで Fatty acid-binding protein 7 は LPS 刺激による TNF- αの産生を制御する2012

    • Author(s)
      香川慶輝 , 徳田信子 , 大和田祐二
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市, 名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7 is involved in the control of neuronal dendritic formation2012

    • Author(s)
      Ebrahimi, M., Tokuda, N., Owada, Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市, 名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Fatty acid binding protein 7 regulates the functions of murine macrophages2012

    • Author(s)
      Miyazaki, H., Tokuda, N., Owada, Y.
    • Organizer
      12th Congress of International Society of Developmental and Comparative Immunology
    • Place of Presentation
      福岡市, ヒルトン福岡シーホーク
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential expression of FABP7 and FABP5 in mouse oligodendrocyte lineage cells2012

    • Author(s)
      Sharifi, K., Tokuda, N., Owada, Y.
    • Organizer
      第10回国際幹細胞学会( ISSCR )年次総会
    • Place of Presentation
      横浜市, パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝クッパー細胞における脂肪酸結合蛋白質( FABP7 )の発現とサイトカイン産生への関与2012

    • Author(s)
      宮崎啓史, 徳田信子, 大和田祐二
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府市, 山梨大学
    • Related Report
      2013 Final Research Report
  • [Presentation] FABP7 in astrocytes is involved in control of neuronal dendritic formation2012

    • Author(s)
      Ebrahimi, M., Tokuda, N., Owada, Y.
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府市, 山梨大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Localization of fatty acid binding protein in mouse placenta and its possible role of fatty acid transport through trophoblasts2012

    • Author(s)
      Islam, A., Tokuda, N., Owada, Y.
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府市, 山梨大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential expression of FABP7 and FABP5 in mouse oligodendrocyte lineage cells2012

    • Author(s)
      Sharifi, K., Kagawa, Y., Ebrahimi, M., Islam, A., Koshy Vaidyan, L., Hara, T., Yasumoto, Y.,
    • Organizer
      第10回国際幹細胞学会(ISSCR)年次総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] Fatty acid binding protein 7 regulates the functions of murine macrophages2012

    • Author(s)
      Miyazaki, H., Sawada, T., Harada, M., Kiyohira, M., Tokuda, N., Adachi, Y., and Owada, Y.
    • Organizer
      12th Congress of International Socitey of Developmental and Comparative Immunology
    • Place of Presentation
      ヒルトン福岡シーホーク (福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP7 is involved in the control of neuronal dendritic formation2012

    • Author(s)
      Ebrahimi, M., Kagawa, Y., Sharifi, K., Yasumoto, Y., Miyazaki, H., Adachi, Y., Sawada, T., Tokuda, N., and Owada, Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Research-status Report
  • [Presentation] アストロサイトでFatty acid-binding protein 7はLPS刺激によるTNF-αの産生を制御する2012

    • Author(s)
      香川 慶輝, Ebrahimi, M., 宮崎 啓史, 安達 泰弘, 澤田 知夫, 徳田 信子, 大和田 祐二
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP5 and FABP7; novel markers in oligodendrocyte lineage2012

    • Author(s)
      Sharifi, K., Ebrahimi, M., Kagawa, Y., Koshy, LV., Hara, T., Yasumoto, Y., Tokuda, N., and Owada, Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Research-status Report
  • [Presentation] Fatty acid binding protein3(FABP3) as a cellular regulator of fatty acid transport from mother to fetus in rodent placenta2012

    • Author(s)
      Islam, A., Tokuda, N., Adachi, Y., Sawada, T., Sharifi, K., Ebrahimi, M., Suzuki, R., and Owada, Y.
    • Organizer
      International Federation of Placenta Associaion (IFPA) 2012 congress
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質FABP3欠損マウスにおける情動行動とCaMキナーゼ活性の異常2012

    • Author(s)
      山本 由似、塩田 倫史、大和田 祐二、福永 浩司
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] Fatty acid-binding protein 7(FABP7) regulates LPS-induced TNF-α production in the astrocytes2012

    • Author(s)
      Kagawa, Y., Ebrahimi, M., Miyazaki, H., Yasumoto, Y., Sharifi, K., Islam, A., Adachi, Y., Sawada, T., Tokuda, N., and Owada, Y.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Control of neuronal dendritic formation by brain-type fatty acid binding protein (FABP7)2012

    • Author(s)
      Ebrahimi, M., Sharifi, K., Kagawa, Y., Yasumoto, Y., Miyazaki, H., Islam, A., Hara, T., Adachi, Y., Sawada, T., Tokuda, N., and Owada, Y.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪酸結合タンパク質(FABP5)は皮脂腺の後期分化調節に関与する2012

    • Author(s)
      山野 希、徳田 信子、安達 泰弘、澤田 知夫、大和田 祐二
    • Organizer
      日本解剖学会第67回中国・四国支部学術集会
    • Place of Presentation
      山口大学医学部(宇部)
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP5 and FABP7 as Novel Markers and Biological Regulators for Oligodendrocyte Lineage2012

    • Author(s)
      Sharifi, K., Ebrahimi, M., Kagawa, Y., Koshy, LV., Hara, T., Yasumoto, Y., Tokuda, N., and Owada, Y.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質を介した免疫系の恒常性制御2012

    • Author(s)
      徳田信子
    • Organizer
      第117回日本解剖学会総会・全国学術集会(リンパ系・免疫系懇話会)(招待講演)
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪酸結合タンパク質による脳の脂質代謝制御とヒト精神疾患との関連2012

    • Author(s)
      大和田祐二
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      信州大学 松本市
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪酸結合タンパク質による神経機能の制御2012

    • Author(s)
      大和田祐二
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝クッパー細胞における脂肪酸結合蛋白質(FABP7)の発現とサイトカイン産生への関与2012

    • Author(s)
      宮崎啓史 ら
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] FABP7 in astrocytes is involved in control of neuronal dendritic formation2012

    • Author(s)
      Majid Ebrahimi, et al.
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] Localization of fatty acid binding protein in mouse placenta and its possible role of fatty acid transport through trophoblasts.2012

    • Author(s)
      Ariful Islam, et al.
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 皮脂腺における脂肪酸結合タンパク質(FABP5)の局在と機能2012

    • Author(s)
      山野希 ら
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学 甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of brain-type fatty acid binding protein (B-FABP/FABP7) in the brain and immune organs2011

    • Author(s)
      Nobuko Tokuda, et al.
    • Organizer
      Joint International Symposium for Soc of Nursing and Health Sciences and 9th Spinal Cord Sciences Summer Symposium for "Neuro-Biosciences(招待講演)
    • Place of Presentation
      山口大学 宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] Expression of FABP7 in normal and injured brain cortex and its role in astrocyte proliferation.2011

    • Author(s)
      Sharifi K, et al.
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質(FABP7)は肝クッパー細胞の機能を修飾する2011

    • Author(s)
      宮崎啓史 ら
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~org-anat/

    • Related Report
      2013 Final Research Report
  • [Remarks] 山口大学大学院医学系研究科器官解剖学分野研究室HP

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~org-anat/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 山口大学大学院 医学系研究科 器官解剖学分野

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~org-anat/

    • Related Report
      2012 Research-status Report
  • [Remarks] 脳科学辞典 脂肪酸結合タンパク質7型

    • URL

      http://bsd.neuroinf.jp/wiki/%E8%84%82%E8%82%AA%E9%85%B8%E7%B5%90%E5%90%88%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~org-anat/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 難聴が生じにくいモデル動物2013

    • Inventor(s)
      鈴木淳、大隅典子、高田雄介、大和田祐二
    • Industrial Property Rights Holder
      東北大学・山口大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-09-13
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 難聴が生じにくいモデル動物2012

    • Inventor(s)
      大隅典子, 高田雄介 , 鈴木淳, 大和田祐二
    • Industrial Property Rights Holder
      国立大学法人東北大学, 国立大学法人山口大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-09-13
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 脳疾患の診断及び予後予測方法並びにそれらに使用するキット2012

    • Inventor(s)
      大和田祐二, 鈴木倫保, 柏原昌次権
    • Industrial Property Rights Holder
      国立大学法人山口大学, DS ファーマバイオメディカル株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-12-25
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 乾癬治療効果の経過観察及び早期の予測方法並びにそれらに使用するキット2011

    • Inventor(s)
      大和田祐二, 奥山隆平, 細江宏彰
    • Industrial Property Rights Holder
      国立大学法人東北大学, 国立大学法人山口大学, DS ファーマバイオメディカル株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-06-13
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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