Effects of plant polyphenols intake during lactation on glucose and lipid metabolism in offspring exposed with maternal protein restriction
| Project/Area Number |
23500960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
SATO SHIN 青森県立保健大学, 健康科学部, 教授 (40310099)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAI Yuuka 青森県立保健大学, 健康科学部, 助教 (60331211)
KURASAKI Masaaki 北海道大学, 大学院・地球環境科学院, 助教 (80161727)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 胎生期低栄養 / 肥満 / 糖尿病 / AMP活性化プロテインキナーゼ / エネルギー代謝 / 植物ポリフェノール / エピジェネティクス / 胎児期低栄養 / AMPK活性化プロテインキナーゼ / ポリフェノール |
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| Research Abstract |
Dietary protein restriction during pregnancy is thought to lead to the development of obesity and glucose intolerance in later life. This study was investigated the effects of maternal plant polyphenols intake during lactation affects AMP-activated protein kinase (AMPK) phosphorylation in the liver of young and adult offspring exposed to fetal malnutrition. Maternal plant polyphenols (azuki bean polyphenols and resveratrol) intake during lactation increased AMPK phosphorylation in the liver of offspring. The results suggest that plant polyphenols intake during lactation activate hepatic AMPK and may affect the glucose and lipid metabolism in adult offspring exposed with maternal protein restriction.
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Report
(4 results)
Research Products
(32 results)
