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Effects of sialic acid on brain function in young and aging rats

Research Project

Project/Area Number 23500963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionChubu University (2012-2014)
University of Shizuoka (2011)

Principal Investigator

YOKOGOSHI Hidehiko  中部大学, 応用生物学部, 教授 (70109320)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsシアル酸 / 記憶学習 / 神経栄養学 / N-アセチルノイラミン酸 / 記憶学習能 / DHA / シアル / N-アセチルノ酸
Outline of Final Research Achievements

The effects of dietary sialic acid in dams on the learning abilities of their pups after weaning were investigated using rats deficient in n-3 fatty acids. During pregnancy and lactation, the female rats were fed the n-3 fatty acid-deficient diet. After weaning, these pups fed the n-3 fatty acid-deficient diet (control)or N-acetlyneuramic acid ontaining n-3 fatty acid-deficient diet.
The learning abilities of the pups were evaluated using an active avoidance test. The pups fed N-acetlyneuramic acid ontaining n-3 fatty acid-deficient diet had high score in active avoidance test than control. the result suggested that N-acetlyneuramic acid feeding had an improving effect on learning and memory behavior.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (1 results)

  • [Journal Article] Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response2012

    • Author(s)
      Atsushi Takeda, Haruna Tamano, et al
    • Journal Title

      Cell.Mol.Neurobiol.

      Volume: 32 Issue: 1 Pages: 41-48

    • DOI

      10.1007/s10571-011-9732-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory2012

    • Author(s)
      Atsushi Takeda, Haruna Tamano, et al
    • Journal Title

      Cell.Mol.Neurobiol.

      Volume: 31 Issue: 7 Pages: 1079-1088

    • DOI

      10.1007/s10571-011-9707-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the edible mushroom Mycoleptodonoides aitchisonii on transient global ischemia-induced monoamine metabolism changes in rat cerebral cortex.2011

    • Author(s)
      Okuyama S, Tashiro K, Lam NV, Hatakeyama T, Terashima T, Yokogoshi H.
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 57 Issue: 1 Pages: 285-291

    • DOI

      10.1089/jmf.2011.1636

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine.2011

    • Author(s)
      Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.
    • Journal Title

      J Sci Food Agric.

      Volume: 92 Issue: 4 Pages: 857-861

    • DOI

      10.1002/jsfa.4658

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the Quality of Dietary Amino Acids Composition on the Urea Synthesis in Rats2011

    • Author(s)
      Tujioka K, Ohsumi M, Hayase K, Yokogoshi H.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 57 Issue: 1 Pages: 48-55

    • DOI

      10.3177/jnsv.57.48

    • NAID

      10028106110

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relieving Occupational Fatigue by Consumption of a Beverage Containing γ-Amino Butyric Acid2011

    • Author(s)
      Kanehira T, Nakamura Y, Nakamura K, Horie K, Horie N, Furugori K, Sauchi Y, Yokogoshi H.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 57 Issue: 1 Pages: 9-15

    • DOI

      10.3177/jnsv.57.9

    • NAID

      10028105911

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] シアル酸の新機能としての神経科学的解析2011

    • Author(s)
      横越英彦、平塚聖一、小井土幸恵、齋藤慎一
    • Organizer
      静岡県立大学学術フォーラム
    • Place of Presentation
      静岡県立大学(静岡)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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