Effects of sialic acid on brain function in young and aging rats
| Project/Area Number |
23500963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Chubu University (2012-2014)
University of Shizuoka (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シアル酸 / 記憶学習 / 神経栄養学 / N-アセチルノイラミン酸 / 記憶学習能 / DHA / シアル / N-アセチルノ酸 |
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| Outline of Final Research Achievements |
The effects of dietary sialic acid in dams on the learning abilities of their pups after weaning were investigated using rats deficient in n-3 fatty acids. During pregnancy and lactation, the female rats were fed the n-3 fatty acid-deficient diet. After weaning, these pups fed the n-3 fatty acid-deficient diet (control)or N-acetlyneuramic acid ontaining n-3 fatty acid-deficient diet.
The learning abilities of the pups were evaluated using an active avoidance test. The pups fed N-acetlyneuramic acid ontaining n-3 fatty acid-deficient diet had high score in active avoidance test than control. the result suggested that N-acetlyneuramic acid feeding had an improving effect on learning and memory behavior.
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Report
(5 results)
Research Products
(7 results)
