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Exhaustive risk evaluation of trans-fatty acid and glycidol fatty acid esther

Research Project

Project/Area Number 23500964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

MASUDA Shuichi  静岡県立大学, 食品栄養科学部, 准教授 (40336657)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsトランス脂肪酸 / グリシドール脂肪酸エステル / 遺伝毒性 / 加熱調理 / 食肉 / 食用油 / コメットアッセイ / 小核試験
Research Abstract

Trans-fatty acid (TFA) was detected in some dietary oils (0.3-1.93g/100g). However, the concentration of TFA was decreased by heating. Though glycidol fatty acid ester (GE) was determined in oils, the levelof GE was also decreased by heating. Treatment of GE showed the siginificantly genotoxcities (reverse mutation, DNA damages and the frequency of micronuclei) in Ames test(TA100), COMET assay and micronuclei test compared to non-treated groups. The concentration of GE in comminuted pig meat heated with charcoal firewas very high (195g/100g meat). From these results, it is demonstrated that we are habitually exposed to TFA and GE that have an influence on the health of human from daily foods. It is important to estimate the risk of these chemicals to human.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (39 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Book (6 results) Remarks (1 results)

  • [Journal Article] In vivo examination of the genotoxicity of the urban air and surface soil pollutant, 3, 6-dinitrobenzo[e]pyrene, with intraperitoneal and intratracheal administration2013

    • Author(s)
      Kato T, Totsuka Y, Hasei T, Watanabe T, Wakabayashi K, Kinae N, Masuda S
    • Journal Title

      Environ. Toxicol

      Volume: 28(10) Pages: 588-594

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems2013

    • Author(s)
      Kato T, Totsuka Y, Ishino K, Matsumoto Y, Tada Y, Nakae D, Goto S, Masuda S, Ogo S, Kawanishi M, Yagi T, Matsuda T, Watanabe M, Wakabayashi K
    • Journal Title

      Nanotoxicology

      Volume: 7(4) Pages: 452-461

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pu-erh Tea Suppresses Diet-Induced Body Fat Accumulation in C57BL/6J Mice by Down-Regulating SREBP-1c and Related Molecules2013

    • Author(s)
      1. Shimamura Y, Yoda M, Sakakibara H, Matsunaga K, Masuda S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 7 Pages: 1455-1460

    • DOI

      10.1271/bbb.130097

    • NAID

      10031190452

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo examination of the genotoxicity of the urban air and surface soil pollutant, 3,6-dinitrobenzo[e]pyrene, with intraperitoneal and intratracheal administration2013

    • Author(s)
      4. Kato T, Totsuka Y, Hasei T, Watanabe T, Wakabayashi K, Kinae N, Masuda S
    • Journal Title

      Environ. Toxicol.

      Volume: 28 Issue: 10 Pages: 588-594

    • DOI

      10.1002/tox.20754

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Residual pesticide concentrations after processing various types of tea and tea infusions2013

    • Author(s)
      Kondo T, Watanabe A, Shitara H, Kaburagi Y, Shibata M, Kanda N, Kurokawa C, Inoue Y, Miyazaki M, Togawa M, Ozawa A, Uchiyama T, Koizumi Y, Nakamura Y, Masuda S
    • Journal Title

      Shokuhin Eiseigaku Zasshi

      Volume: 54 Pages: 259-264

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in Mutagenic Activity of Genistein after a Nitirite Treatment2012

    • Author(s)
      Masuda S, Shimamura Y , Kato T , Tan Yu-Feng , Iwamoto K , and Kinae N
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 76(5) Pages: 938-941

    • Related Report
      2013 Final Research Report
  • [Journal Article] A new prenylflavonoid isolated from propolis collected in the Solomon Islands2012

    • Author(s)
      Inui S, Shimamura Y, Masuda S, Shirafuji K, Moli RT, Kumazawa S
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 76(5) Pages: 1038-1040

    • Related Report
      2013 Final Research Report
  • [Journal Article] Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity2012

    • Author(s)
      Inui S, Hosoya T, Shimamura Y, Masuda S, Ogawa T, Kobayashi H, Shirafuji K, Moli RT, Kozone I, Shin-ya K, Kumazawa S
    • Journal Title

      J. Agric. Food Chem

      Volume: 60(47) Pages: 11765-70

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems2012

    • Author(s)
      Kato, T., et al
    • Journal Title

      Nanotoxicology

      Volume: (in press) Issue: 4 Pages: 452-461

    • DOI

      10.3109/17435390.2012.674571

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Change in Mutagenic Activity of Genistein after a Nitrite Treatment2012

    • Author(s)
      Masuda S, Shimamura Y,Kato T,Tan Yu-Feng,Iwamoto K,and Kinae N
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 5 Pages: 938-941

    • DOI

      10.1271/bbb.110957

    • NAID

      10030752757

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems2011

    • Author(s)
      Koyama N, Yasui M, Oda Y, Suzuki S, Satoh T, Suzuki T, Matsuda T, Masuda S, Kinae N, Honma M
    • Journal Title

      Environ Mol Mutagen

      Volume: 52(1) Pages: 11-19

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acrylamide genotoxicity in young versus adult gpt delta male rats2011

    • Author(s)
      Koyama N, Yasui M, Kimura A, Takami S, Suzuki T, Masumura K, Nohmi T, Masuda S, Kinae N, Matsuda T, Imai T, Honma M
    • Journal Title

      Mutagenesis

      Volume: 26(4) Pages: 545-549

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acrylamide genotoxicity in young versus adult gpt delta male rats.2011

    • Author(s)
      Koyama N, Yasui M, Kimura A, Takami S, Suzuki T, Masumura K, Nohmi T, Masuda S, Kinae N, Matsuda T, Imai T, Honma M
    • Journal Title

      Mutagenesis

      Volume: 26 Pages: 545-549

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo genotoxicity induced by fullerene (C60) and kaolin.2011

    • Author(s)
      Totsuka Y, Kato T, Masuda S, Ishino K, Matsumoto Y, Goto S, Kawanishi M, Yagi T, Wakabayashi K
    • Journal Title

      Genes Environ.

      Volume: 33 Pages: 14-20

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems.2011

    • Author(s)
      Koyama N, Yasui M, Oda Y, Suzuki S, Satoh T, Suzuki T, Matsuda T, Masuda S, Kinae N, Honma M.
    • Journal Title

      Environ. Mol. Mutagen.

      Volume: 52 Pages: 11-19

    • Related Report
      2011 Research-status Report
  • [Presentation] 食肉中の食中毒菌の分布とその抑制に関する研究2013

    • Author(s)
      新家桃香, 島村裕子, 青野博志, 青野盈瓠 , 篠田和代, 佐藤勝浩, 村田容常, 増田修一
    • Organizer
      日本農芸化学会 2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 食中毒菌の毒素産生および活性を抑制する植物食品の探索2013

    • Author(s)
      青木菜摘, 島村裕子, 田中 隆, 村田容常, 増田修一
    • Organizer
      日本農芸化学会 2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 食肉の加熱調理により生成するグリシドール脂肪酸エステルに関する研究2013

    • Author(s)
      平井央子, 島村裕子, 増田修一
    • Organizer
      第106回日本食品衛生学会学術講演会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 食肉中の食中毒菌の分布と電解水による殺菌効果に関する研究2013

    • Author(s)
      平石美季, 島村裕子, 新家桃香, 佐藤勝浩, 青野博志, 青野盈瓠, 篠田和代, 村田容常, 増田修一
    • Organizer
      第106回日本食品衛生学会学術講演会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] グリシドール及びグリシドール脂肪酸エステル類の遺伝毒性に関する研究2012

    • Author(s)
      龚 琬, 島村裕子, 米谷民雄, 増田修一
    • Organizer
      第104回日本食品衛生学会学術講演会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 金銀花の抗糖尿病効果に関する研究2012

    • Author(s)
      柴田昌治, 島村裕子, 佐藤緑, 楊平, 増田修一
    • Organizer
      第17回日本フードファクター学会(JSoFF)学術集会・第 9回日本カテキン学会総会 合同大会
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo コメットアッセイにおける手法間差の検討(2)2012

    • Author(s)
      京谷恭弘, 岩元莉香, 飯尾美沙子, 寺田めぐみ, 増田修一
    • Organizer
      日本環境変異原学会 第41回大会
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivoコメットアッセイにおける手法間差の検討(2)2012

    • Author(s)
      京谷恭弘, 岩元莉香, 飯尾美沙子, 寺田めぐみ, 増田修一
    • Organizer
      日本環境変異原学会 第41回大会
    • Place of Presentation
      静岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ソロモン諸島産プロポリスに関する化学的研究2012

    • Author(s)
      乾 沙王里,島村裕子,増田修一,白藤謙一,Reuben T Moli, 熊澤茂則
    • Organizer
      日本農芸化学会 2012年度(平成24年度)大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 静岡県地場産品のアクリルアミドの生成及び遺伝毒性に対する抑制効果2011

    • Author(s)
      飯尾美沙子, 平野元美, 増田修一, 米谷民雄, 中村好志
    • Organizer
      日本農芸化学会 2011年度大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 静岡県地場産品におけるアクリルアミドの生成及び遺伝毒性に対する抑制効果(2)2011

    • Author(s)
      飯尾美沙子, 平野元美, 島村裕子, 中村好志, 米谷民雄, 増田修一
    • Organizer
      第102回日本食品衛生学会学術講演会
    • Place of Presentation
      秋田
    • Related Report
      2013 Final Research Report
  • [Presentation] メイラード反応由来新規変異原性物質 ABAQ の生体内生成に関する研究2011

    • Author(s)
      山田昌徳, 島村裕子, 戸塚ゆ加里, クゥリバリ・スレウマン, 田村友佳, 長谷井友尋, 若林敬二, 渡辺徹志, 増田修一
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] プーアール茶の抗肥満効果に関する研究2011

    • Author(s)
      依田美友紀,森 郁乃,島村裕子,榊原啓之,増田修一
    • Organizer
      第8回日本カテキン学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 静岡県地場産品のアクリルアミドの生成及び遺伝毒性に対する抑制効果(2)2011

    • Author(s)
      飯尾美沙子,平野元美,島村裕子,中村好志,米谷民雄,増田修一
    • Organizer
      第102回日本食品衛生学会学術講演会
    • Place of Presentation
      秋田
    • Related Report
      2011 Research-status Report
  • [Presentation] 黄色ブドウ球菌のコロニー間におけるエンテロトキシンA遺伝子伝播に関わる環境因子について2011

    • Author(s)
      島村裕子,増田修一,村田容常
    • Organizer
      第102回日本食品衛生学会学術講演会
    • Place of Presentation
      秋田
    • Related Report
      2011 Research-status Report
  • [Presentation] メイラード反応由来新規変異原性物質ABAQの生体内生成に関する研究2011

    • Author(s)
      山田昌徳,島村裕子,戸塚ゆ加里,クゥリバリ・スレウマン,田村友佳,長谷井友尋,若林敬二, 渡辺徹志,
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] ソロモン諸島産プロポリスに関する化学的研究2011

    • Author(s)
      乾 沙王里,島村裕子,増田修一,白藤謙一,Reuben T Moli, 熊澤茂則
    • Organizer
      第2回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Book] 健康・栄養学用語辞典2012

    • Author(s)
      増田修一他106名 (大森正英 編)
    • Total Pages
      726
    • Publisher
      中央法規出版 株式会社
    • Related Report
      2011 Research-status Report
  • [Book] 抗ストレス食品の開発と展望2012

    • Author(s)
      増田修一他54名
    • Total Pages
      295
    • Publisher
      株式会社シーエムシー出版
    • Related Report
      2011 Research-status Report
  • [Book] 健康と食の安全を考えた食品衛生学実験2011

    • Author(s)
      増田修一他10名 (中村好志 編)
    • Total Pages
      122
    • Publisher
      株式会社 アイ・ケイコーポレーション
    • Related Report
      2011 Research-status Report
  • [Book] 株式会社 南江堂2011

    • Author(s)
      増田修一他15名 (那須正夫、和田啓爾 編)
    • Total Pages
      349
    • Publisher
      食品衛生学「食の安全」の科学
    • Related Report
      2011 Research-status Report
  • [Book] 茶論2011

    • Author(s)
      増田修一、島村裕子、下位香代子、木苗直秀
    • Total Pages
      29
    • Publisher
      NPO法人 日本茶インストラクター協会
    • Related Report
      2011 Research-status Report
  • [Book] 株式会社 講談社2011

    • Author(s)
      増田修一他36名(日本香辛料学会 編)
    • Total Pages
      221
    • Publisher
      スパイスなんでも小事典
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/foodhygn/index.html

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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