Function and structure of food-derived and endogenous collagen peptide in damaged regions of skin
| Project/Area Number |
23500966
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
SATO KENJI 京都府立大学, 生命環境科学研究科(系), 教授 (00202094)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMURA Yasutaka 東京家政大学, 短期大学部, 講師 (20373178)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | コラーゲン / ペプチド / 線維芽細胞 / 創傷治癒 / 皮膚 / Pro-Hyp / コラーゲンペプチド / Hyp-Gly / コラーゲン由来ペプチド |
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| Research Abstract |
The present study demonstrates that occurrence of Pro-Hyp in the inflammatory and wound healing regions of mice. Pro-Hyp has been demonstrated to be present human blood after ingestion of collagen peptide. In addition, primary cultured fibroblast from mouse skin expressed mesenchymal stem cell marker (p75NTR) and peptide transporters and incorporated Pro-Hyp and started to grow on collagen gel, which were extensively decreased after passage. The present study demonstrates the significant role of Pro-Hyp in wound healing process and explores mechanism for enhance meant of wound healing by ingestion of collagen peptide.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate2012
Author(s)
Shigemura, Y., Nakaba, M., Shiratsuchi, E., Suyama, M., Yamada, M., Kiyono, T. Fukamizu, K., Park, E. Y., Nakamura, Y., Sato, K
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Journal Title
J. Agric. Food Chem
Volume: 60
Pages: 5128-5133
Related Report
Peer Reviewed
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[Journal Article] Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate2012
Author(s)
Shigemura,Y., Nakaba, M., Shiratsuchi, E., Suyama, M., Yamada, M., Kiyono, T. Fukamizu, K., Park, E. Y., Nakamura, Y., Sato, K.
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Journal Title
J. Agric. Food Chem.
Volume: 60
Issue: 20
Pages: 5128-5133
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate2011
Author(s)
Shigemura, Y., Akaba, S., Kawashima, E., Park E.-Y. Nakamura, Y., Sato, K
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Journal Title
Food Chemistry
Volume: 129
Pages: 1019-1024
Related Report
Peer Reviewed
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[Book] Fish-elastin hydrolysate. In "Marine Proteins and Peptides" Kim, S.-K. Edit2013
Author(s)
Shiratsuchi, E., Nakaba, M., Shigemura, Y., Yamada, M., Sato, K
Publisher
Wiley-Blackwell
Related Report
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