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Function and structure of food-derived and endogenous collagen peptide in damaged regions of skin

Research Project

Project/Area Number 23500966
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKyoto Prefectural University

Principal Investigator

SATO KENJI  京都府立大学, 生命環境科学研究科(系), 教授 (00202094)

Co-Investigator(Kenkyū-buntansha) SHIGEMURA Yasutaka  東京家政大学, 短期大学部, 講師 (20373178)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsコラーゲン / ペプチド / 線維芽細胞 / 創傷治癒 / 皮膚 / Pro-Hyp / コラーゲンペプチド / Hyp-Gly / コラーゲン由来ペプチド
Research Abstract

The present study demonstrates that occurrence of Pro-Hyp in the inflammatory and wound healing regions of mice. Pro-Hyp has been demonstrated to be present human blood after ingestion of collagen peptide. In addition, primary cultured fibroblast from mouse skin expressed mesenchymal stem cell marker (p75NTR) and peptide transporters and incorporated Pro-Hyp and started to grow on collagen gel, which were extensively decreased after passage. The present study demonstrates the significant role of Pro-Hyp in wound healing process and explores mechanism for enhance meant of wound healing by ingestion of collagen peptide.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (14 results) (of which Invited: 5 results) Book (8 results) Remarks (2 results)

  • [Journal Article] Dose-dependent changes in the levels of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysate ingestion2014

    • Author(s)
      Shigemura, Y., Kubomura, D., Sato, Y., Sato, K
    • Journal Title

      Food Chemistry

      Volume: 159 Pages: 328-332

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト血中に存在する食事由来ペプチド 構造・含量・機能2014

    • Author(s)
      佐藤健司
    • Journal Title

      Peptide News Letter Japan

      Volume: 92 Pages: 1-3

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate2012

    • Author(s)
      Shigemura, Y., Nakaba, M., Shiratsuchi, E., Suyama, M., Yamada, M., Kiyono, T. Fukamizu, K., Park, E. Y., Nakamura, Y., Sato, K
    • Journal Title

      J. Agric. Food Chem

      Volume: 60 Pages: 5128-5133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate2012

    • Author(s)
      Shigemura,Y., Nakaba, M., Shiratsuchi, E., Suyama, M., Yamada, M., Kiyono, T. Fukamizu, K., Park, E. Y., Nakamura, Y., Sato, K.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 60 Issue: 20 Pages: 5128-5133

    • DOI

      10.1021/jf300497p

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate2011

    • Author(s)
      Shigemura, Y., Akaba, S., Kawashima, E., Park E.-Y. Nakamura, Y., Sato, K
    • Journal Title

      Food Chemistry

      Volume: 129 Pages: 1019-1024

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 美容とアンチエイジングのための素材~コラーゲンペプチドを中心に~2011

    • Author(s)
      佐藤健司
    • Journal Title

      Food Style 21

      Volume: 15 Pages: 34-37

    • Related Report
      2013 Final Research Report
  • [Presentation] Pro-Hyp の皮膚線維芽細胞増殖促進効果2014

    • Author(s)
      佐藤 健司
    • Organizer
      第14回抗加齢医学総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Pro-Hyp の皮膚線維芽細胞増殖促進効果2014

    • Author(s)
      佐藤健司
    • Organizer
      第14回日本抗加齢医学総会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 食事由来コラーゲンペプチドの真皮に及ぼす影響2013

    • Author(s)
      佐藤 健司
    • Organizer
      第13回抗加齢医学総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ペプチドの機能2013

    • Author(s)
      佐藤 健司
    • Organizer
      日本臨床栄養学会・日本臨床栄養協会 第11回連合大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Incorporation of food-derived collagen peptides, Pro-Hyp and Hyp-Gly, into primary cultured fibroblast from mice skin - possible trigger for growth of fibroblast2013

    • Author(s)
      Satou, K
    • Organizer
      ISNFF Annual Conference
    • Place of Presentation
      Taipei
    • Related Report
      2013 Final Research Report
  • [Presentation] 食事由来コラーゲンペプチドの真皮に及ぼす影響2013

    • Author(s)
      佐藤健司
    • Organizer
      第13回日本抗加齢医学総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ペプチドの機能2013

    • Author(s)
      佐藤健司
    • Organizer
      第35回日本臨床栄養学会総会・第34回日本臨床栄養協会総会 第11回大連合大会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 食事由来コラーゲンペプチドの真皮に及ぼす影響2013

    • Author(s)
      佐藤健司
    • Organizer
      抗加齢医学総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 真皮コラーケンの産生メカニスム2012

    • Author(s)
      佐藤 健司
    • Organizer
      第12回抗加齢医学総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 真皮コラーゲンの産生メカニズム2012

    • Author(s)
      佐藤健司
    • Organizer
      抗加齢医学総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Impact of extracellular matrix protein hydrolysates on human health2011

    • Author(s)
      Sato, K
    • Organizer
      matrix protein hydrolysates on human health
    • Place of Presentation
      Cincinnati, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Food-derived collagen peptides in human blood-structure and biological functions2011

    • Author(s)
      Sato, K
    • Organizer
      ICOFF 2011
    • Place of Presentation
      Taipei, Chinese Taipei
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of extracellular matrix protein hydrolysates on human health2011

    • Author(s)
      Sato, k
    • Organizer
      102nd AOCS Annual Meeting(招待講演)
    • Place of Presentation
      Cincinnati, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Food-derived collagen peptides in human blood-structure and biological functions2011

    • Author(s)
      Sato, K
    • Organizer
      ICOFF 2011(招待講演)
    • Place of Presentation
      Taipei, Chinese Taipei
    • Related Report
      2011 Research-status Report
  • [Book] Fish-elastin hydrolysate. In "Marine Proteins and Peptides" Kim, S.-K. Edit2013

    • Author(s)
      Shiratsuchi, E., Nakaba, M., Shigemura, Y., Yamada, M., Sato, K
    • Publisher
      Wiley-Blackwell
    • Related Report
      2013 Final Research Report
  • [Book] ペプチドの吸収2013

    • Author(s)
      佐藤健司 依田悠里
    • Total Pages
      11
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Research-status Report
  • [Book] Fish-elastin hydrolysate: Development and impact on skin and blood vessels.Marine Proteins and Peptides2013

    • Author(s)
      Shiratsuchim E., Nakaba, M., Shigemura, Y., Yamada, M., Sato, K
    • Total Pages
      20
    • Publisher
      Wiley-Blackwell
    • Related Report
      2012 Research-status Report
  • [Book] Effect of marine collagen peptide on skin condition. In "Marine Cosmeceuticals Trends and Prospective" Kim, S.-K. Edit2012

    • Author(s)
      Sato, K., Shigemura, Y
    • Publisher
      CRC Press, New York
    • Related Report
      2013 Final Research Report
  • [Book] Effect of marine collagen peptide on skin condition In "Marine Cosmeceuticals"2012

    • Author(s)
      Sato, K. and Shigemura, Y
    • Total Pages
      6
    • Publisher
      CRC Press
    • Related Report
      2012 Research-status Report
  • [Book] Proteins and peptides for complicated disease type. In "Bioactive Food Proteins and Peptides. Application in Human Health2011

    • Author(s)
      Sato, K.
    • Total Pages
      17
    • Publisher
      CRC Press. Taylor & Francis Group
    • Related Report
      2011 Research-status Report
  • [Book] Proteins and peptides for complicated disease type. In "Bioactive Food Proteins and Peptides. Applicationa in Human Health" Hettirarachchy, N. S., Sato, K., Marshall, M. R., Kannan, A. Edit

    • Author(s)
      Sato, K
    • Publisher
      CRC Press. Taylor & Francis Group, Boca Raton, FL, USA
    • Related Report
      2013 Final Research Report
  • [Book] ペプチドの吸収「食品機能性成分の吸収・代謝機構」 宮澤陽夫監修

    • Author(s)
      佐藤健司, 依田悠里
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Remarks] RESEARCHER INFORMATION SYSTEM

    • URL

      http://www.senryaku-kyoto.jp/contents/search/index.php?mode=show&seq=1165

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www2.kpu.ac.jp/shomuka/gakujyutsu/data/33101069.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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