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Suppression of starch digestion by phenolic compounds and the reaction products with nitrous acid

Research Project

Project/Area Number 23500968
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKyushu Dental College

Principal Investigator

TAKAHAMA Umeo  九州歯科大学, 歯学部, 教授 (30106273)

Co-Investigator(Renkei-kenkyūsha) HIROTA Sachiko  東亜大学, 教授 (00312140)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords澱粉 / フラボノイド / 消化抑制 / 疎水的結合 / 澱粉消化 / ポリフェノール類 / 疎水性 / カテキン類 / ジニトロソカテキン / チオシアン酸付加物 / アズキ色素 / カテキン / クエルセチン / 亜硝酸 / 澱粉消化抑制 / 酸化還元 / ニトロソ化 / vignacyanidin / アミラーゼ / 疎水的相互作用
Outline of Final Research Achievements

We take starch as a food component, and the starch is hydrolyzed into glucose in the intestine to be absorbed into body. The faster hydrolysis of starch may result in diabetes. Such rapid digestion of starch to glucose is possible when rice and wheat flour, which contain relatively high starch, are ingested. Previously, humans took cereals and root crops, which contain various flavonoids, as sources of starch. It is known that the rates of starch digestion in the latter foods are slower than those in rice and wheat flour. In this study, we indicated that that the slow digestion of starch from cereals and root crops was due to hydrophobic binding of flavonoids to starch decreasing the ability to be a substrate for α-amylase.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) Book (3 results)

  • [Journal Article] Quercetin-7-glucoside suppresses nitrite-induced formation of dinitrosocatechins and their quinones in catechin/nitrite systems under stomach simulating conditions2015

    • Author(s)
      Morina, F., Takahama, U., Yamauchi, R., Hirota, S., Veljovic-Jovanovic, S.
    • Journal Title

      Food and Function

      Volume: 6 Pages: 219-229

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactions of polyphenols in masticated apple fruit with nitrite under stomach simulating conditions: Formation of nitroso compounds and thiocyanate conjugates2015

    • Author(s)
      Hirota, S., and Takahama, U.
    • Journal Title

      Food Research International

      Volume: xx Pages: 20-26

    • DOI

      10.1016/j.foodres.2015.05.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactions of Apple Fruit Polyphenols with Nitrite under Conditions of the Gastric Lumen: Generation of Nitric Oxide and Formation of Nitroso Catechins2014

    • Author(s)
      Sachiko Hirota, Umeo Takahama
    • Journal Title

      Food Science and Technology Research

      Volume: 20 Issue: 2 Pages: 439-447

    • DOI

      10.3136/fstr.20.439

    • NAID

      130004463443

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interactions between (+)-catechin and quercetin during their oxidation by nitrite under the conditions simulating the stomach2014

    • Author(s)
      Veljovic-Jovanovic, S., Morina, F., Yamauchi, R., Hirota, S., and Takahama, U.
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 62 Issue: 21 Pages: 4951-4959

    • DOI

      10.1021/jf500860s

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactions of (+)-catechin with salivary nitrite and thiocyanate under conditions simulating the gastric lumen: Production of dinitrosocatechin and its thiocyanate conjugate2014

    • Author(s)
      Takahama, U., Yamauchi, R., and Hirota, S.
    • Journal Title

      Free Radical Research

      Volume: 48 Pages: 956-966

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Starch can inhibit nitrite-dependent oxidation of crocin in gastric lumen increasing bioavalability of carotenoids.2013

    • Author(s)
      Sachiko Hirota, Umeo Takahama
    • Journal Title

      Food Science and Technology Research

      Volume: 19 Pages: 1121-1126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interactions of starch with a catechin-cyanidin pigment (vignacyanidin) isolated from Vigna angularis bean2013

    • Author(s)
      Takahama, U., Yamauchi, R., Hirota, S.
    • Journal Title

      Food Chemistry

      Volume: 141 Issue: 3 Pages: 2600-2605

    • DOI

      10.1016/j.foodchem.2013.04.065

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a cyanidin-catechin pigment from adzuki bean (Vigna angularis).2013

    • Author(s)
      Takahama, U., Yamauchi, R., Hirota, S.
    • Journal Title

      Food Chemistry

      Volume: 141 Issue: 1 Pages: 282-288

    • DOI

      10.1016/j.foodchem.2013.02.113

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of starch on nitrous acid-induced oxidation of kaempferol and inhibition of α-amylase-catalyzed digestion of starch by kaempferol under conditions simulating the stomach and the intestine.2013

    • Author(s)
      Takahama, U., Hirota, S.
    • Journal Title

      Food Chemistry

      Volume: 141 Issue: 1 Pages: 313-319

    • DOI

      10.1016/j.foodchem.2013.02.037

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nitrogen oxides toxicology of the aerodigestive tract.2013

    • Author(s)
      Umeo Takahama, Toshihiro Ansai, Sachiko Hirota
    • Journal Title

      Advances in Molecular Toxicology

      Volume: 7 Pages: 129-177

    • DOI

      10.1016/b978-0-444-62645-5.00004-3

    • ISBN
      9780444626455
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhancement of iron(II)-dependent ...2012

    • Author(s)
      Takahama, U., Hirota, S.
    • Journal Title

      Chemical Research in Toxicology

      Volume: 25 Issue: 1 Pages: 207-215

    • DOI

      10.1021/tx200438q

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of the food additives sulfite2012

    • Author(s)
      Takahama, U., Hirota, S.
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 60 Pages: 1102-1112

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of xanthine oxidase activity..2011

    • Author(s)
      Takahama, U., Koga, Y., Hirota, S., Yamauchi, R.
    • Journal Title

      Food Chemistry

      Volume: 126 Issue: 4 Pages: 1808-1811

    • DOI

      10.1016/j.foodchem.2010.12.009

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of buckwheat starch digestion..2011

    • Author(s)
      Takahama, U., Hirota, S.
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 59 Issue: 11 Pages: 6277-6283

    • DOI

      10.1021/jf2006326

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Interaction of quercetin with radicals derived from catechin and dinitrosocatechin under the conditions simulating the gastric lumen.2014

    • Author(s)
      Tahakama U., Morina F., Veljovic-Javanovic S., Yamauchi R., Hirota S.
    • Organizer
      14th International Nutrition and Diagnostics Conference
    • Place of Presentation
      Hotel DAP, Prague
    • Year and Date
      2014-09-02 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃腔条件下での亜硝酸による 6,8-ジニトロソカテキンの 酸化に対するケルセチンおよびケルセチン配糖体の影響2014

    • Author(s)
      F. Morina, S. Veljovic-Jovanovic, 山内亮、廣田幸子、高濱有明夫
    • Organizer
      第61回日本食品科学工学会
    • Place of Presentation
      中村学園大学
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液の亜硝酸塩とチオシアン酸塩は二価鉄イオンと胃腔条件下で反応する2012

    • Author(s)
      高濱有明夫 廣田幸子
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 澱粉は亜硝酸によるクチナシ黄の酸化を抑え、クチナシ黄はアミラーゼによる澱粉の消化を促進する2012

    • Author(s)
      廣田幸子、高濱有明夫
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 食品添加物である亜硫酸塩による胃腔条件下での一酸化窒素の生成の抑制2012

    • Author(s)
      高濱有明夫、廣田幸子
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] パンクレアチン依存の澱粉消化は澱粉/胆汁酸2011

    • Author(s)
      高濱有明夫 廣田幸子
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      お茶の水女子大学
    • Related Report
      2011 Research-status Report
  • [Presentation] ソバ粉澱粉の消化はメタノール抽出物によって阻害される2011

    • Author(s)
      廣田幸子 高濱有明夫
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      お茶の水女子大学
    • Related Report
      2011 Research-status Report
  • [Book] Reactions of quercetin and its glycosides in the oral cavity and the stomach. In Quercetin2012

    • Author(s)
      Takahma, U., Hirota, S.
    • Total Pages
      12
    • Publisher
      Nova Science Pub. Inc.
    • Related Report
      2012 Research-status Report
  • [Book] Oral Health Care2012

    • Author(s)
      Takahama, U., Hirota, S.
    • Total Pages
      12
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report
  • [Book] Flour and Bread2011

    • Author(s)
      Takahama, U. et al. (edited by R. Preedy et al.)
    • Total Pages
      11
    • Publisher
      Academic Press (ISBN: 9780123808868)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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