Analysis of the effect of molecular hydrogen on diabetes using quantitative evaluation system of oxidative stress in vivo

• Project/Area Number: 23500971
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nippon Medical School
• Principal Investigator: KAMIMURA Naomi 日本医科大学, 付置研究所, 准教授 (60283800)
• Co-Investigator(Kenkyū-buntansha): OHTA Shigeo 日本医科大学, 大学院・医学研究科, 教授 (00125832)
• Co-Investigator(Renkei-kenkyūsha): WOLF Alexander 日本医科大学, 老人病研究所生化学部門, 助教 (20434136)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病 / 酸化ストレス / 抗酸化剤 / 健康と食生活

Research Abstract

We have reported that molecular hydrogen (H2) has great potential for improving oxidative stress-related diseases by inhaling H2 gas, injecting saline with dissolved H2, or drinking water with dissolved H2 (H2-water). In this study, we showed drinking H2-water improved obesity and hyperglycemia in db/db mice. Furthermore, we developed a transgenic mouse that can quantitatively evaluate the oxidative stress in the body. We crossed the mice with db/db mice to measure oxidative stress in living mice.

Research Products

• [Journal Article] Real-Time Monitoring of Oxidative Stress in Live Mouse Skin (2014)
  • Author(s): Wolf AM, Nishimaki K, Kamimura N, Ohta S
  • Journal Title: J Invest Dermatol Volume: 34(6) Pages: 1701-1709
  • Peer Reviewed
• [Journal Article] Real-Time Monitoring of Oxidative Stress in Live Mouse Skin (2014)
  • Author(s): Wolf AM, Nishimaki K, Kamimura N, Ohta S
  • Journal Title: J Invest Dermatol Volume: 34(6) Issue: 6 Pages: 1701-1709
  • DOI: 10.1038/jid.2013.428
  • Peer Reviewed
• [Journal Article] Regular Moderate or Intense Exercise Prevents Depression-Like Behavior without Change of Hippocampal Tryptophan Content in Chronically Tryptophan-Deficient and Stressed Mice (2013)
  • Author(s): Lee H, Ohno M, Ohta S, Mikami T
  • Journal Title: PLoS One Volume: 8(7)
  • Peer Reviewed
• [Journal Article] Pilot study of H2 therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial (2013)
  • Author(s): Takahashi M, Wolf AM, Watari E, Norose Y, Ohta S, Takahashi H
  • Journal Title: Mov Disord Volume: 28(6) Pages: 836-839
  • Peer Reviewed
• [Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice (2013)
  • Author(s): Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T
  • Journal Title: PLoS One Volume: 8(7)
  • Peer Reviewed
• [Journal Article] Intense exercise enhances the hippocampal proliferation of progenitor cells via activating the Flk1 signaling cascade in mice (2013)
  • Author(s): Lee H, Kiuchi T, Muto J, Ohta S, Mikami T
  • Journal Title: GAZZETA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE A Journal on Internal Medicine and Pharmacology Volume: (in press)
  • Peer Reviewed
• [Journal Article] 3271 番位 tRNALue(UUR) 変異を有するミトコンドリア糖尿病の 15 年を超えた追跡経過観察 (2013)
  • Author(s): 鈴木吉彦, 島田朗, 佐野元昭, 太田成男
  • Journal Title: 糖尿病学会誌 Volume: 56(3) Pages: 173-8
  • Peer Reviewed
• [Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice (2013)
  • Author(s): Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T
  • Journal Title: PLoS One Volume: 8(7) Issue: 7 Pages: e69178-e69178
  • DOI: 10.1371/journal.pone.0069178
  • Peer Reviewed
• [Journal Article] H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia (2012)
  • Author(s): Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S
  • Journal Title: J. Am. Heart Assoc Volume: 1(5)
  • Peer Reviewed
• [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis (2012)
  • Author(s): Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H, Matsumoto M, Chiba K, Toyama Y, Miyamoto T
  • Journal Title: J. Bone Miner Res Volume: 27(9) Pages: 2015-2023
  • Peer Reviewed
• [Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS (2012)
  • Author(s): Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
  • Journal Title: Intern. Med Volume: 51(24) Pages: 3351-3357
  • NAID: 130003308162
  • Peer Reviewed
• [Journal Article] Biochemistry of mitochondria, life and intervention 2010 (2012)
  • Author(s): Koga Y, Tanaka M, Ohta S, Wei YH
  • Journal Title: Biochim Biophys Acta Volume: 1820(5) Pages: 551-552
  • Peer Reviewed
• [Journal Article] Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity (2012)
  • Author(s): Kashio A, Sakamoto T, Kakigi A, Suzuki M, Suzukawa K, Kondo K, Sato Y, Asoh S, Ohta S, Yamasoba T
  • Journal Title: Gene Ther Volume: 19(12) Pages: 1141-1149
  • Peer Reviewed
• [Journal Article] Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model (2012)
  • Author(s): Sakurazawa M, Katsura K, Saito M, Asoh S, Ohta S, Katayama Y
  • Journal Title: Brain Res Volume: 1430 Pages: 86-92
  • Peer Reviewed
• [Journal Article] Improvement of the post-thaw qualities of Okinawan native Agu pig sperm frozen in an extender supplemented with antiapoptotic PTD-FNK protein (2012)
  • Author(s): Shimokawa K, Oshiro R, Yamanaka K, Ashizawa K, Ohta S, Tatemoto H
  • Journal Title: Theriogenology Volume: 78(7) Pages: 1446-1455
  • Peer Reviewed
• [Journal Article] Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases (2012)
  • Author(s): Ohta S
  • Journal Title: Biochim Biophys Acta Volume: 1820(5) Pages: 586-594
  • Peer Reviewed
• [Journal Article] Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines (2012)
  • Author(s): Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP
  • Journal Title: Nat Commun Volume: 3 Issue: 1 Pages: 1250-1261
  • DOI: 10.1038/ncomms2238
  • Peer Reviewed
• [Journal Article] H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia (2012)
  • Author(s): Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S
  • Journal Title: J. Am. Heart Assoc Volume: 1(5) Issue: 5
  • DOI: 10.1161/jaha.112.003459
  • Peer Reviewed
• [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice (2011)
  • Author(s): Kamimura N, Nishimaki K, Ohsawa I. Ohta S
  • Journal Title: Obesity (Silver Spring) Volume: 19(7) Pages: 1396-1403
  • Peer Reviewed
• [Journal Article] Hydrogen Therapy Attenuates Irradiation-induced Lung Damage by Reducing Oxidative Stress (2011)
  • Author(s): Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, Fukuda, Y
  • Journal Title: Am. J. Physiol. Lung Cell Mol. Physiol Volume: 301(4)
  • Peer Reviewed
• [Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain (2011)
  • Author(s): Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Wolf AM, Amo T, Ohta S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M, Adachi T
  • Journal Title: Circ Res Volume: 109(4) Pages: 396-406
  • Peer Reviewed
• [Journal Article] Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide (2011)
  • Author(s): Hanaoka T, Kamimura N, Yokota T, Takai S, Ohta S
  • Journal Title: Med. Gas Res Volume: 1(1) Pages: 18-18
  • Peer Reviewed
• [Journal Article] Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion (2011)
  • Author(s): Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M
  • Journal Title: J Biol Chem Volume: 286(43) Pages: 37458-37469
  • Peer Reviewed
• [Journal Article] Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects (2011)
  • Author(s): Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N
  • Journal Title: Neurobiol. Dis Volume: 41(1) Pages: 111-118
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA alterations in colorectal cancer cell lines (2011)
  • Author(s): Chihara N, Amo T, Tokunaga A, Yuzuriha R, Wolf AM, Asoh S, Suzuki H, Uchida E, Ohta S
  • Journal Title: J Nippon Med Volume: 78(1) Pages: 13-21
  • NAID: 130004147079
  • Peer Reviewed
• [Journal Article] The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research (2011)
  • Author(s): Ohta S., Nakao, A., Ohno, K
  • Journal Title: Med. Gas Res Volume: 1(1) Pages: 10-10
  • Peer Reviewed
• [Journal Article] Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications (2011)
  • Author(s): Ohta S
  • Journal Title: Curr. Pharm. Des Volume: 17(22) Pages: 2241-2252
  • Peer Reviewed
• [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice (2011)
  • Author(s): Kamimura N, Nishimaki K, Ohsawa I, Ohta S
  • Journal Title: Obesity Volume: 19(7) Issue: 7 Pages: 1396-1403
  • DOI: 10.1038/oby.2011.6
  • Peer Reviewed
• [Journal Article] Overexpression of KLF15 in adipocytes of mice results in down-regulation of SCD1 expression in adipocytes and consequent enhancement of glucose-induced insulin secretion (2011)
  • Author(s): Nagare T, Sakaue H, et al
  • Journal Title: J Biol Chem Volume: Vol.286 Issue: 43 Pages: 37458-37469
  • DOI: 10.1074/jbc.m111.242651
  • Peer Reviewed
• [Journal Article] Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide (2011)
  • Author(s): Hanaoka T, Kamimura N, Yokota T, Takai S, Ohta S
  • Journal Title: Med. Gas Res Volume: 1(1) Issue: 1 Pages: 18-18
  • DOI: 10.1186/2045-9912-1-18
  • Peer Reviewed
• [Journal Article] Hydrogen Therapy Attenuates Irradiation-induced Lung Damage by Reducing Oxidative Stress (2011)
  • Author(s): Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, (他7名)
  • Journal Title: Am. J. Physiol. Lung Cell Mol. Physiol Volume: 301(4) Issue: 4 Pages: L415-L426
  • DOI: 10.1152/ajplung.00008.2011
  • Peer Reviewed
• [Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. (2011)
  • Author(s): Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Alexander MW, Amo T, Ota S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M, Adachi T.
  • Journal Title: Circ Res Volume: 109(4) Issue: 4 Pages: 396-406
  • DOI: 10.1161/circresaha.111.243097
  • Peer Reviewed
• [Presentation] 水素分子による網膜保護効果ーラットex vivo網膜培養系での解析ー (2014)
  • Author(s): 横田隆、上村尚美、五十嵐勉、高椅浩、小原澤英彰、太田成男
  • Organizer: 第４回分子状水素医学シンポジウム
  • Place of Presentation: 東京
• [Presentation] 低濃度の分子状水素による連鎖的脂質過酸化の抑制効果 (2014)
  • Author(s): 井内勝哉、西槙貴代美、井本明美、一宮治美、李 炫溱、上村尚美、太田成男
  • Organizer: 第４回分子状水素医学シンポジウム
  • Place of Presentation: 東京
• [Presentation] アルツハイマー病モデルマウスに対する骨髄単核球移植の予防・治療効果 (2013)
  • Author(s): 上村尚美, 金丸拓也, 横田隆, 井内勝哉, 西槙貴代美, 高見新也, 赤芝洋紀, 志鷹義嗣, 桂研一郎, 片山泰朗, 太田成男
  • Organizer: 第36回日本分子生物学会
• [Presentation] Double transgenic mutants carrying a mutant gene of amyloid precursor protein and dominant-negative gene of mitochondrial aldehyde dehydrogenase 2 accelerates Alzheimer-like phenotypes in transgenic mice (2013)
  • Author(s): Naomi Kamimura, Takuya Kanamaru, Takashi Yokota, Katsuya Iuchi, Kiyomi Nishimaki, Shinya Takami, Hiroki Akashiba, Yoshitsugu Shitaka, Ken-ichiro Katsura, Yasuo Katayama, and Shigeo Ohta
  • Organizer: 第13回日本ミトコンドリア学会年会
• [Presentation] APP TRANSGENIC MICE WITH OXIDATIVE STRESS (2013)
  • Author(s): Naomi Kamimura, Takuya Kanamaru, Takashi Yokota, Katsuya Iuchi, Kiyomi Nishimaki, Shinya Takami, Hiroki Akashiba, Yoshitsugu Shitaka, Ken-ichiro Katsura, Yasuo Katayama, and Shigeo Ohta
  • Organizer: AD/PD2013 (The 11th International Conference On Alzheimer's & Parkinson's Diseases)
• [Presentation] 糖尿病モデルマウスにおける分子状水素の効果と遺伝子発現誘導の網羅的解析 (2013)
  • Author(s): 上村尚美, 一宮治美, 太田成男
  • Organizer: 第3回分子状水素医学シンポジウム
• [Presentation] 紫外線による皮膚の生体内ストレスイメージング (2013)
  • Author(s): Wolf Alexander, 中島裕也, 上村尚美, 西槙貴代美, 太田成男
  • Organizer: 日本香粧品学会
  • Place of Presentation: 東京
• [Presentation] Double transgenic mutants carrying a mutant gene of amyloid precursor protein and dominant-negative gene of mitochondrial aldehyde dehydrogenase 2 accelerates Alzheimer-like phenotypes in transgenic mice. (2013)
  • Author(s): 上村尚美
  • Organizer: 第13回日本ミトコンドリア学会
  • Place of Presentation: 東京
• [Presentation] Effect of Intravenous Transplantation of Bone Marrow-Derived Mononuclear Cells in the Prevention and Treatment of Transgenic Mouse Models of Alzheimer's Disease. (2013)
  • Author(s): 村尚美、金丸拓也、横田隆、井内勝哉、西槙貴代美、高見新也、赤芝洋紀、志鷹義嗣、片山泰朗、太田成男
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] DNA microarray analysis of hepatic gene expression induced by molecular hydrogen in typeII diabetes mellitus model mice (db/db) (2013)
  • Author(s): 一宮治美、上村尚美、太田成男
  • Organizer: 第36回日本分子生物学
  • Place of Presentation: 神戸
• [Presentation] APP TRANSGENIC MICE WITH OXIDATIVE STRESS. (2013)
  • Author(s): Naomi Kamimura, Takuya Kanamaru, Takashi Yokota, Katsuya Iuchi, Kiyomi Nishimaki, Shinya Takami, Hiroki Akashiba, Yoshitsugu Shitaka, Ken-ichiro Katsura, Yasuo Katayama, and Shigeo Ohta.
  • Organizer: AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
  • Place of Presentation: Florence, Italy
• [Presentation] EFFECTS OF INTRAVENOUS TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELL ON ALZHEIMER’S DISEASE MOUSE MODELS. (2013)
  • Author(s): Takuya Kanamaru, Naomi Kamimura, Katsuya Iuchi, Kiyomi Nishimaki, Takashi Yokota, Shinya Takami, Hiroki Akashiba, Yoshitsugu Shitaka, Ken-ichiro Katsura, Yasuo Katayama, and Shigeo Ohta
  • Organizer: AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
  • Place of Presentation: Florence, Italy
• [Presentation] ラット心停止モデルを用いた水素吸入療法と低体温療法の予後改善効果の検討 (2013)
  • Author(s): 林田敬、佐野元昭、上村尚美、横田隆、太田成男、福田恵一、堀進悟
  • Organizer: 第３回分子状水素医学シンポジウム
  • Place of Presentation: 東京
• [Presentation] 糖尿病モデルマウスにおける分子状水素の効果と遺伝子発現誘導の網羅的解析 (2013)
  • Author(s): 上村尚美、一宮治美、太田成男
  • Organizer: 第３回分子状水素医学シンポジウム
  • Place of Presentation: 東京
• [Presentation] ヒト変異 APP高発現マウスと酸化ストレス亢進マウスとの掛け合わせマウスの解析 (2012)
  • Author(s): 上村尚美, 金丸拓也, 横田隆, 井内勝哉, 西槙貴代美, 高見新也, 赤芝洋紀, 志鷹義嗣, 桂研一郎, 片山泰朗, 太田成男
  • Organizer: 第35回日本分子生物学会
• [Presentation] ミトコンドリアアルデヒド脱水素酵素２活性欠損マウス（DAL101マウス）に対する骨髄単核球移植の認知機能改善効果 (2012)
  • Author(s): 金丸拓也、上村尚美、井内勝哉、西槙貴代美、横田隆、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
  • Organizer: 第12回日本ミトコンドリア学会年会
  • Place of Presentation: つくば
• [Presentation] Optical Recording of Oxidative Stress in Live Mice (2012)
  • Author(s): Wolf Alexander M、西槙貴代美、上村尚美、太田成男
  • Organizer: 第12回日本ミトコンドリア学会年会
  • Place of Presentation: つくば
• [Presentation] ヒト変異APP高発現マウスと酸化ストレス亢進マウスとの掛け合わせマウスの解析 (2012)
  • Author(s): 上村尚美、金丸拓也、横田隆、井内勝哉、西槙貴代美、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] アルツハイマーモデルマウスに対する他家骨髄単核球投与の認知機能改善効果 (2012)
  • Author(s): 金丸拓也、上村尚美、井内勝哉、西槙貴代美、横田隆、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] Optical Recording of Oxidative Stress in Live Mice (2012)
  • Author(s): Wolf Alexander M、西槙貴代美、上村尚美、太田成男
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] 水素発生素材の利用とその安全性の検討 (2012)
  • Author(s): 一宮治美、上村尚美、太田成男
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] 心停止蘇生後症候群に対する水素吸入療法の有効性の検討 (2012)
  • Author(s): 林田敬、佐野元昭、上村尚美、横田隆、太田成男、福田恵一、堀進悟
  • Organizer: 第40回日本救急医学会総会
  • Place of Presentation: 京都
• [Presentation] ラット心停止モデルを用いた水素吸入療法と低体温療法の予後改善効果の検討 (2012)
  • Author(s): 林田敬、佐野元昭、上村尚美、横田隆、太田成男、福田恵一、堀進悟
  • Organizer: 第27回日本Shock学会
  • Place of Presentation: 東京
• [Presentation] 水素を発生する新素材投与の安全性と効果 (2012)
  • Author(s): 一宮治美
  • Organizer: 第二回分子状水素医学シンポジウム
  • Place of Presentation: 東京
• [Presentation] Inhalation of hydrogen gas during cardiopulmonary resuscitation improves neurologic and cardiac outcome in a rat cardiac arrest model. (2012)
  • Author(s): 林田敬
  • Organizer: 第７６回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] The effect of molecular hydrogen on various gene expression in liver in db/db mice (2011)
  • Author(s): Naomi Kamimura, Kiyomi Nishimaki, Harimi Ichimiya, Shigeo Ohta
  • Organizer: 第34回日本分子生物学会
• [Presentation] Molecular hydrogen upregulates hepatic mitochondrial lipid metabolism-related genes, reduces oxidative stress, improves obesity in type2 deabetes model mice (2011)
  • Author(s): Naomi Kamimura, Kiyomi Nishimaki, Harimi Ichimiya, Ikuroh Ohsawa, Shigeo Ohta
  • Organizer: 5th SFRR (Society for Free Radical Research)-Asia, 8th ASMRM (Asian symposium of Mitochondrial Research and Medicine), 11th J-mit(Japanese Mitochondrial Research and Medicine)
• [Presentation] Molecular hydrogen enhances the expression of a wide variety of lipid metabolism-related genes in liver and reduces oxidative stress, improves obesity in db/db mice (2011)
  • Author(s): Naomi Kamimura, Kiyomi Nishimaki, Ikuroh Ohsawa, Shigeo Ohta
  • Organizer: EUROMIT 8 (The eighth European Meating on Mitochondrial Pathology)
• [Presentation] Molecular hydrogen enhances the expression of a wide variety of lipid metabolism-related genes in liver and reduces oxidative stress, improves obesity in db/db mice. (2011)
  • Author(s): Kamimura N.
  • Organizer: Euromit 8
  • Place of Presentation: Zaragoza, Spain
• [Presentation] MOLECULAR HYDROGEN UPREGULATES HEPATIC MITOCHONDRIAL LIPID METABOLISM-RELATED GENES, REDUCES OXIDATIVE STRESS, IMPROVES OBESITY IN TYPE2 DEABETES MODEL MICE (2011)
  • Author(s): Kamimura N.
  • Organizer: 5th SFRR-Asia, 8th ASMRM & 11th J-mit
  • Place of Presentation: Kagoshima, Japan.
• [Presentation] In vivo measurements of skin oxidative stress using mice expressing redox-sensitive GFP. (2011)
  • Author(s): Wolf A.
  • Organizer: 5th SFRR-Asia, 8th ASMRM & 11th J-mit
  • Place of Presentation: Kagoshima, Japan.
• [Presentation] Transgenic mice expressing the redox-sensitive green fluorescent protein. (2011)
  • Author(s): Nishimaki K.
  • Organizer: 5th SFRR-Asia, 8th ASMRM & 11th J-mit
  • Place of Presentation: Kagoshima, Japan.
• [Presentation] The effect of molecular hydrogen on various gene expression in liver in db/db mice. (2011)
  • Author(s): 上村尚美
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] IN VIVO MEASUREMENT OF SKIN OXIDATIVE STRESS USING MICE EXPRESSING REDOX-SENSITIVE GFP. (2011)
  • Author(s): Wolf A.
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] TRANSGENIC MICE EXPRESSING roGFP HAVE POTENTIAL TO ESTIMATE OXIDATIVE STRESS IN VIVO. (2011)
  • Author(s): 西槙貴代美
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html
• [Remarks] 日本医科大学老人病研究所生化学部門
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html
• [Remarks] 日本医科大学老人病研究所
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html
• [Remarks]
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html