| Project/Area Number |
23500972
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Kanagawa Institute of Technology |
|---|
Principal Investigator |
KIYOSE Chikako 神奈川工科大学, 応用バイオ科学部, 教授 (50272745)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ビタミンＥ / CEHC / 脂肪細胞 / 炎症性サイトカイン / 共培養法 / アロエ抽出物 / 食品成分 / 共培養 / 3T3-L1細胞 / WEHI-274.1細胞 / ビタミンE / 抗炎症作用 |
|---|
| Research Abstract |
Vitamin E has eight different naturally occurring forms: four tocopherols (Toc) and four tocotrienols (Toc-3), among which alha-Toc, in particular, is knowns to be a major antioxidant for protection fo cellular membranes. Vitamin E analogs are metabolized to carboxyethyl-hydroxychroman (CEHC) in vivo and excreted into urine. Although the CEHC form is the main metabolite of vitamin E, CEHC -particularly gamma-CEHC- has also been reported to have some physiological functions, for example as a natriuretic hormone and an antioxidant. Therefore, I investigated the effect of vitamin E and its metabolite on the adipocytes induced inflammation. At first, I determined the culture method of adipocytes (3T3-L1 cells) with macrophages (RAW264.7 cells). Next, I examined the effect of vitamin E on the adipocytes induced inflammation. According to this result, I was shown that gamma-tocotorienol could not suppress the inflammation of adipocytes.
|
