Effect of oral immunotherapy with hypoallergenic formula for severe milk allergenic patients
| Project/Area Number |
23500973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fujita Health University |
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Principal Investigator |
INUO Chisato 藤田保健衛生大学, 医学部, 助教 (30586780)
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| Co-Investigator(Kenkyū-buntansha) |
URISU Atsuo 藤田保健衛生大学, 坂文種報徳會病院 小児科, 客員教授 (20193972)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低アレルゲン / 食物アレルギー / 免疫療法 / アレルギー / 食物 / 加工食品 |
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| Research Abstract |
To cow's milk allergy patients, the usefulness of immunotherapy to induce remission by taking milk have been reported. However, skin symptoms, gastrointestinal symptoms, and respiratory symptoms are induced frequently by the milk oral immunotherapy. In this study, we investigated the safety and efficacy of oral immunotherapy using peptide milk. The peripheral blood basophils activations in the blood of the severe milk allergy patients against peptides milk were lower than that of normal milk. In the double-blind food challenge test, the severe milk allergy patients can eat the larger amount of peptide milk than that of normal milk. The oral immunotherapy using peptides milk increased the durable amount of milk without any symptoms for the milk allergy patients in patients of 80%.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant, Annals of allergy, asthma & immunology : official publication of the American College of Allergy2013
Author(s)
Nomura T. , Tsuge I. , Inuo C. , Nakajima Y. , Kondo Y. , Sugiura S. , Murata H. , Iguchi T. , Terada A. , Saitoh S. , Hashimoto S., Urisu A
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Journal Title
Asthma, & Immunology
Volume: 110
Pages: 388-390
Related Report
Peer Reviewed
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[Journal Article] New approach for improving the safety of oral immunotherapy for food allergy2012
Author(s)
Urisu A. , Tanaka K. , Ogura K. , Naruse N. , Hirata N. , Nakajima Y. , Inuo C. , Suzuki S. , Ando H. , Kondo Y. , Tsuge I. , Yamada K., Kimura M
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Journal Title
Clinical & Experimental Allergy Reviews
Volume: 12
Pages: 25-28
Related Report
Peer Reviewed
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[Journal Article] Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children2011
Author(s)
Torii S. , Torii A. , Itoh K. , Urisu A. , Terada A. , Fujisawa T. , Yamada K. , Suzuki H. , Ishida Y. , Nakamura F. , Kanzato H. , Sawada D. , Nonaka A. , Hatanaka M., Fujiwara S
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Journal Title
Int. Arch. Allergy Immunol
Volume: 154
Pages: 236-45
Related Report
Peer Reviewed
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[Presentation] ミルクアレルギー児における活性化マーカーCD154 を用いた抗原特異的 T 細胞の解析2014
Author(s)
山脇一夫, 柘植郁哉, 大久保悠里, 中島陽一, 犬尾千聡, 野村孝泰, 森雄司, 田中健一, 鈴木聖子, 近藤康人, 宇理須厚雄
Organizer
第26回日本アレルギー学会春季臨床大会
Place of Presentation
京都
Related Report
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