| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Coleus forskohlii extract (CFE) standardized to 10% forskolin is a popular herbal ingredient for commercial weight loss dietary supplement, because forskolin has been shown to increase c-AMP accumulation and lipolysis in fat cells. Feeding CFE to mice increased liver weight, induced cytochrome P450(CYP) and fatty liver. CFE attenuated the anticoagulant action of warfarin, and hypoglycemic action of tolbutamide via induction of hepatic CYP2C. Dietary starch potentiated CFE-induced CYP induction. Inductions of CYP and fatty liver by CFE were not due to forskolin, but due to un-identified substances that were soluble in ether.
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