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Involvement of DNA recombination repair proteins in chromosomal translocations

Research Project

Project/Area Number 23501259
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Carcinogenesis
Research InstitutionHiroshima University

Principal Investigator

SUN Jiying  広島大学, 原爆放射線医科学研究所, 講師 (80397926)

Co-Investigator(Kenkyū-buntansha) TASHIRO Satoshi  広島大学, 原爆放射線医科学研究所, 教授 (20243610)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords染色体転座 / ATM / 組換え修復 / RAD51 / RPA / DNA組換え修復 / RPA2
Research Abstract

Chromosome translocations induced by ionizing radiation and chemotherapeutic agents, has been shown to lead to malignant transformation. However, the mechanism of chromosome translocations is still unclear. Chromosome translocations involving the MLL gene on 11q23 are the most frequent chromosome abnormalities in secondary leukemias associated with chemotherapy employing etoposide. Dysfunction of ATM, a DNA damage signaling regulator, increases the incidence of 11q23 chromosome translocations. We showed that ATM deficiency results in the excessive binding of the DNA recombinase RAD51 at the translocation breakpoint cluster region (BCR) of MLL gene after etoposide exposure. In this study, we showed that phosphorylation of RPA2 by ATM plays an important role in the regulation of RAD51 binding to the BCR of MLL gene after etoposide exposure.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (15 results)

  • [Journal Article] Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damage2013

    • Author(s)
      Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S
    • Journal Title

      J Cell Sci

      Volume: 126 Pages: 5284-5292

    • DOI

      10.1242/jcs.133744

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition2013

    • Author(s)
      Sakogawa K, Aoki Y, Misumi K, Hamai Y, Emi M, Hihara J, Shi L, Kono K, Horikoshi Y, Sun J, Ikura T, Okada M, Tashiro S
    • Journal Title

      Cancer Sci. 2013 Sep 5

      Volume: 104 Issue: 12 Pages: 1593-1609

    • DOI

      10.1111/cas.12281

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines.2013

    • Author(s)
      Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S.
    • Journal Title

      Int J Oncol.

      Volume: 42(6) Issue: 6 Pages: 1951-60

    • DOI

      10.3892/ijo.2013.1899

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities2012

    • Author(s)
      Shi L, Fujioka K, Sun J, Kinomura A, Inaba T, Ikura T, Ohtaki M, Yoshida M, Kodama Y, Livingston GK, Kamiya K, Tashiro S
    • Journal Title

      Radiat Res

      Volume: 177(5) Pages: 533-538

    • URL

      http://jrr.oxfordjournals.org

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 白血病のゲノム不安定性2012

    • Author(s)
      田代 聡、孫 継英
    • Journal Title

      日本臨床

      Volume: 70巻 Pages: 383-387

    • URL

      http://www.nippon-rinsho.co.jp

    • Related Report
      2013 Final Research Report
  • [Journal Article] 構造関連蛋白質による放射線誘発核内フォーカス形成を介した組換え修復の制御機構2012

    • Author(s)
      時 林、孫 継英、木野村 愛子、沖本 聡志、田代 聡
    • Journal Title

      長崎醫學會雜誌

      Volume: 87 Pages: 199-201

    • Related Report
      2013 Final Research Report
  • [Journal Article] A modified system for analyzing ionizing radiation-induced chromosome abnormalities.2012

    • Author(s)
      Shi L, Fujioka K, Sun J, Kinomura A, Inaba T, Ikura T, Ohtaki M, Yoshida M, Kodama Y, Livingston GK, Kamiya K, Tashiro S.
    • Journal Title

      Radiat Res.

      Volume: 177 Pages: 533-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA22011

    • Author(s)
      Hosoya N, Okajima M, Kinomura A, Fujii Y, Hiyama T, Sun J, Tashiro S, Miyagawa K
    • Journal Title

      EMBO Rep

      Volume: 23;13(1) Pages: 44-51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.2011

    • Author(s)
      Hosoya N, Okajima M, Kinomura A, Fujii Y, Hiyama T, Sun J, Tashiro S, Miyagawa K.
    • Journal Title

      EMBO Rep.

      Volume: 13 Pages: 44-55

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Involvement of chromatin remodeling factor in chromosomal translocation2014

    • Author(s)
      Jiying Sun, Aiko Kinomura, Masayuki Harata, Tsuyoshi Ikura, and Satoshi Tashiro
    • Organizer
      4^<th> RIRBM International Symposium
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular mechanism of etoposide induced 11q23 chromosome translocation2013

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura~2 and Satoshi Tashiro
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Involvement of recombination repair proteins in 11q23 chromosome translocation2013

    • Author(s)
      Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 染色体転座形成におけるクロマチン再構成因子の関与2013

    • Author(s)
      孫継英、木野村愛子、鈴木秀和、田代聡
    • Organizer
      第9回広島大学・長崎大学連携研究事業カンファランス
    • Place of Presentation
      広島
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of recombination repair proteins in 11q23 chromosome translocation2013

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Satoshi Tashiro
    • Organizer
      3^<rd> RIRBM International Symposium
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of recombination repair proteins in 11q23 chromosome translocation2012

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki,Tsuyoshi Ikura, Dipanjan Chowdhury, Satoshi Tashiro
    • Organizer
      第35回分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 染色体転座形成の分子機構の解明2012

    • Author(s)
      孫継英、木野村愛子、鈴木秀和、田代聡
    • Organizer
      第8回広島大学・長崎大学連携研究事業カンファランス
    • Place of Presentation
      長崎
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanism of 11q23 chromosomal translocation after etoposide treatment2012

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro
    • Organizer
      第55回放射線影響学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2012

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Dipanjan Chowdhury and Satoshi Tashiro
    • Organizer
      2^<nd> RIRBM International Symposium
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of recombination repair proteins in 11q23 chromosome2012

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura and Satoshi Tashiro
    • Organizer
      第35回分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanism of 11q23 chromosomal translocation after etoposide treatment2011

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki,Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 染色体転座形成における組換え修復タンパク質の役割2011

    • Author(s)
      孫継英、木野村愛子、鈴木秀和、田代聡
    • Organizer
      第7回広島大学・長崎大学連携研究事業カンファランス
    • Place of Presentation
      広島
    • Year and Date
      2011-06-04
    • Related Report
      2013 Final Research Report
  • [Presentation] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2011

    • Author(s)
      Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar and Satoshi Tashiro
    • Organizer
      第54回放射線影響学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanism of 11q23 chromosomal translocation after etoposide treatment2011

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2011

    • Author(s)
      Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki1, Shuki Mizutani, Roland Kanaar and Satoshi Tashiro
    • Organizer
      第54回放射線影響学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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