| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
By analyzing epigenome and microRNA expression profiling in colorectal cancer (CRC) cells, we identified a series of epigenetically silenced microRNA genes. We found that DNA methyltransferase 1 (DNMT1) is essential for the maintenance of cancer stem-like cells (CSC)/ cancer initiating cells (CIC), and we also identified microRNA genes which are differentially expressed in CSC/CIC. We carried out genome and epigenome analysis in precursor and malignant lesions in colorectum, and identified aberrant DNA methylation patterns in the premalignant stage. Finally, by performing integrative analysis of molecular, pathological and endoscopic findings of premalignant colorectal lesions, we identified a novel surface microstructure which is specific to the precursor lesions of CpG island methylator phenotype (CIMP)-positive CRC.
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