| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Leptin is elevated in obesity and may be involved in carcinogenesis including colorectal cancers. The objective of this study was to investigate the role of leptin signal on colitis-related colon carcinogenesis.
In current study, we indicated that Leptin was effective in inhibiting colitis-related colon carcinogenesis through suppression of mucosal inflammation and hyperlipidemia in the ob/ob mice (leptin-deficient obese genetic background). Our results suggest that the leptin might be useful for prevention of inflammation-related colon cancers.
Furthermore, we showed that C57BL/KsJ mice strains are less sensitive to inflammation-related colon carcinogenesis compared with C57BL/6J mice and these differences may be due to the difference in their levels of mucosal inflammation of the colon. These results provided the useful information in the inflammation-related mouse colon carcinogenesis model.
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