Role of p63 in metastasis and therapeutic resistance of bladder cancer
Project/Area Number |
23501266
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor biology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
KOGA Fumitaka 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (10285851)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | 膀胱癌 / 転移 / 治療抵抗性 / p63 / 化学放射線治療抵抗性 / リスク因子 / 癌幹細胞 / p63 |
Outline of Final Research Achievements |
The following findings were obtained in the present study series and reported in international medical journals. (1) Bladder cancer stem cells are resistant to cisplatin and they lose expression of p63 protein, suggesting that loss of p63 is associated with cisplatin resistance. (2) No significant association was obtained between chemoradiation resistance and p63 expression profile in muscle-invasive bladder cancer. (3)Overexpression of erbB2 in bladder cancer is significantly associated with resistance to chemoradiation and bladder cancer death.
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Report
(5 results)
Research Products
(10 results)
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[Journal Article] Role of diffusion-weighted magnetic resonance imaging in predicting sensitivity to chemoradiotherapy in muscle-invasive bladder cancer2012
Author(s)
Yoshida S, Koga F, Kobayashi S, Ishii C, Tanaka H, Tanaka H, Komai Y, Saito K, Masuda H, Fujii Y, Kawakami S, Kihara K
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 83
Related Report
Peer Reviewed
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[Presentation] Pre-therapeutic risk stratification of muscle-invasive bladder cancer patients treated with chemoradiation-based selective bladder-sparing approach2014
Author(s)
Koga F, Inoue M, Kijima T, Yoshida S, Ishioka J, Matsuoka Y, Numao N, Saito K, Masuda H, Fujii Y, Kihara K
Organizer
29th annual EAU congress
Place of Presentation
Stockholm
Year and Date
2014-04-14
Related Report
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[Presentation] Diffusion-weighted MRI predicts sensitivity to chemoradiation in muscle-invasive bladder cancer2012
Author(s)
Koga F, Yoshida S, Kobayashi S, Ishii C, Tanaka Hiroshi, Fujii Y, Tanaka Hajime, Masuda H, Saito K, Komai Y, Kawakami S, Kihara K
Organizer
27th annual EAU congress
Place of Presentation
Paris
Related Report
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