Roles of Lutheran in tumor cell adhesion and migration
| Project/Area Number |
23501270
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MITAKA Toshihiro 札幌医科大学, 医学部, 教授 (50231618)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ラミニン / ルテラン / インテグリン / 免疫グロブリンスーパーファミリー / 細胞接着 / 細胞外マトリックス / 免疫グロブリンスパーファミリー / 癌の転移・浸潤 / 細胞・組織 / 細胞運動 |
|---|
| Research Abstract |
Lutheran (Lu), an immunoglobulin superfamily transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM). Lu/B-CAM is a specific receptor for laminin alpha5, a subunit of laminin-511 that is a major component of basement membranes in various tissues. Therefore it is likely that the interaction between Lu/B-CAM and laminin alpha5 involves in tumor cell invasion and metastasis. In this study we discovered an antibody that inhibited the binding of Lu/B-CAM to laminin alpha5 and provided mechanistic insight in tumor cell migration on laminin-511. We also showed that Lu/B-CAM released from cell surface was a candidate marker for hepatocellular carcinoma.
|
Report
(4 results)
Research Products
(54 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] 基底膜2012
Author(s)
吉川大和
-
Journal Title
脳科学辞典 http://bsd.neuroinf.jp/wiki/基底膜 2012年
Volume: -
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
