14-3-3beta-FBI1/Akirin2 complex promotes tumorigenicity and metastasis
| Project/Area Number |
23501271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TASHIRO Fumio 東京理科大学, 基礎工学部, 教授 (70089332)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Hirotada 東京理科大学, 基礎工学部生物工学科, 助教 (40400254)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | がん制御因子 / 14-3-3 / FBI1/Akinin2 / 転移 / がん促進遺伝子 / 癌幹細胞 / 上皮間葉転換 / がん抑制遺伝子 / 14-3-3ファミリータンパク質 |
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| Research Abstract |
We previously demonstrated that 14-3-3beta protein promotes cell growth and tumorigenicity of rat K2 hepatocellular carcinoma cells. We identified FBI1/Akirin2 as a binding partner of 14-3-3beta and showed that the complex of these proteins promotes tumorigenicity and metastasis of K2 cells. Based on microarray expression analysis, BCAM and SPARC were identified as the downregulated target genes of the oncogenic 14-3-3beta-FBI1/Akirin2 complex. BCAM and SPARC are suppressive oncoprotein, and that FBI1/Akirin2 is involved in tumorigenicity and metastasis of hepatoma through the downregulation of suppressive oncogenes. Furthermore, we demonstrated that FBI1/Akirin2 performs an oncogenic function in LLC1 Lewis lung carcinoma cells. Although further investigation is required, these results suggest that FBI1/Akirin2 may perform an universal oncogenic function in various cancers.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.2013
Author(s)
Akiyama H, Iwahana Y, Suda M, Yoshimura A, Kogai H, Nagashima A, Ohtsuka H, Komiya Y, Tashiro F
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Journal Title
PLoS One
Volume: 8
Issue: 11
Pages: e78716-e78716
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of secreted protein acidic and rich in cysteine (SPARC) downregulation in malignant conversion of aflatoxin B<sub>1</sub>-induced rat hepatocellular carcinoma K2 cells2013
Author(s)
Suda M, Kamoshida H, Hayashi T, Ogawa M, Ohtsuka H, Murakama S, Yuko Komiya Y, Murakama Y, Akiyama H, Tashiro F
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Journal Title
JSM Mycotoxins
Volume: 63
Issue: 2
Pages: 151-159
DOI
NAID
ISSN
0285-1466, 1881-0128
Related Report
Peer Reviewed
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[Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013
Author(s)
Yuko Atsumi, Aki lnase, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagami, Mitsuko Masutani, Ken-ichi Yoshioka
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Journal Title
The Journal of Biological Chemistry
Volume: 288巻
Issue: 19
Pages: 13269-13277
DOI
Related Report
Peer Reviewed
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[Journal Article] Arf/p53 module, which induces apoptosis, downregulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013
Author(s)
Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka KI.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein2011
Author(s)
Ozeki C., Sawai Y., Shibata T., Kohno T., Okamoto K., Yokota J., Tashiro F., Tanuma S., Sakai R., Kawase T., Kitabayashi I., Taya Y., and Ohki R
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Journal Title
J Biol Chem
Volume: 286(20)
Issue: 20
Pages: 18251-60
DOI
Related Report
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