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Analysis of Sp1-dependent adaptation mechanism of cancer cells to hypoxia for tumor microenvironment-targeted therapy

Research Project

Project/Area Number 23501280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionKanagawa Cancer Center Research Institute

Principal Investigator

KOIZUME Shiro  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, その他 (60416063)

Co-Investigator(Kenkyū-buntansha) MIYAGI Yohei  神奈川県立がんセンター臨床研究所, 部長 (00254194)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsハイポキシア / 卵巣癌 / 遺伝子発現
Research Abstract

Accumulating evidences have suggested that tumor microenvironment is an attractive target of cancer therapy. However, there are few effective strategies to accomplish it. We previously showed that FVII gene is synergistically induced under serum staved hypoxia in ovarian cancer cells. Mechnism of this transcriptional upregulation is associates with HIF2-Sp1 interaction and distinct from that of authentic hypoxia responsive genes such as VEGF. In this study, we investigated detailed mechanism of this novel transcriptional regulation. Genes regulated by similar Sp1 dependent mechanism and their function were further explored by various experiments. We found that ICAM-1 protein is robustly induced by this mechanism and contributes to growth accerelation of ovarian clear cell carcinoma cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (37 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Annexin A4 is involved in proliferation, chemoresistance and migration and invasion in ovarian clear cell adenocarcinoma cells.2013

    • Author(s)
      Mogami T, Yokota N, Asai-sato M, Yamada R, Koizume S, Sakuma Y, Yoshihara M, Nakamura Y, Takano Y, Hirahara F, Miyagi Y, and Miyagi E.
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 11 Pages: 1-8

    • DOI

      10.1371/journal.pone.0080359

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells.2013

    • Author(s)
      Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, and Miyagi Y.
    • Journal Title

      Lab Invest.

      Volume: 93 Issue: 10 Pages: 1137-1146

    • DOI

      10.1038/labinvest.2013.102

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NF-kB signaling is activated and confers resistance to apoptosis in three-dimentionally cultured EGFR-mutant lung adenocarcinoma cells.2012

    • Author(s)
      Sakuma, Y
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 243 Issue: 4 Pages: 667-671

    • DOI

      10.1016/j.bbrc.2012.06.009

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells2012

    • Author(s)
      Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
    • Journal Title

      Nucleic Acid Research

      Volume: 40(12) Issue: 12 Pages: 5389-5401

    • DOI

      10.1093/nar/gks201

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between RAS gene mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort2012

    • Author(s)
      Fukahori M, Yoshida A, Hayashi H, Yoshihara M, Matsukuma S, Sakuma Y, Koizume S, Okamoto N, Kondo T, Masuda M, and Miyagi Y
    • Journal Title

      Thyroid

      Volume: 22 Issue: 7 Pages: 683-689

    • DOI

      10.1089/thy.2011.0261

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutunt lung adenocarcinomas more efficiently than Src inhibitors2012

    • Author(s)
      Sakuma Y, et al
    • Journal Title

      Laboratory Investigation

      Volume: 92 Issue: 3 Pages: 371-383

    • DOI

      10.1038/labinvest.2011.187

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between RAS gene mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort.2012

    • Author(s)
      Fukahori, M
    • Journal Title

      Thyroid

      Volume: 22 Pages: 683-689

    • DOI

      10.1089/thy.2011-0261

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simple and precise detection of UGT1A1 polymorphisms with a modified loop-hybrid mobility shift assay using Cy5-labeled loop probes2011

    • Author(s)
      Matsukuma S, Saito H, Yamada K, Okamoto N, Ishikawa T, Yoshihara M, Koizume S, Sakuma Y, and Miyagi Y
    • Journal Title

      Clin. Chim. Acta.

      Volume: 412 Issue: 17-18 Pages: 1668-1672

    • DOI

      10.1016/j.cca.2011.05.021

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential detection of KRAS mutations in codons 12 and 13 with a modified loop-hybrid (LH) mobility shift assay using an insert-type LH-generator2011

    • Author(s)
      Matsukuma S, Yoshihara M, Suda T, Shiozawa M, Akaike M, Ishikawa, T, Koizume S, Sakuma Y, and Miyagi Y
    • Journal Title

      Clin. Chim. Acta.

      Volume: 412 Issue: 19-20 Pages: 1874-1878

    • DOI

      10.1016/j.cca.2011.06.030

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis2011

    • Author(s)
      Sakuma Y, Tsunezumi J, Nakamura Y, Yoshihara M, Matsukuma S, Koizume S, and Miyagi Y
    • Journal Title

      Oncol. Rep.

      Volume: 25 Issue: 3 Pages: 661-667

    • DOI

      10.3892/or.2010.1123

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple and precise detection of UGT1A1 polymorphisms with a modified loop-hybrid mobility shift assay using Cy5-labeled loop probes.2011

    • Author(s)
      Matsukuma, S
    • Journal Title

      Clin. Chim. Acta.

      Volume: 412 Pages: 1668-1672

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential detection of KRAS mutations in codons 12 and 13 with a modified loop-hybrid (LH) mobility shift assay using an insert-type LH-generator.2011

    • Author(s)
      Matsukuma, S
    • Journal Title

      Clin. Chim. Acta.

      Volume: 412 Pages: 1874-1878

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mild phenotype in Pelizaeus-Merzbacher disease caused by a PLP1-specific mutation2010

    • Author(s)
      Osaka H, Koizume S, Aoyama H, Iwamoto H, Kimura S, Nagai J, Kurosawa K, and Yamashita S
    • Journal Title

      Brain Dev.

      Volume: 32 Issue: 9 Pages: 703-707

    • DOI

      10.1016/j.braindev.2009.11.004

    • NAID

      10027492517

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells2009

    • Author(s)
      Yokota, N., Koizume, S., Miyagi, E., Hirahara, F., Nakamura, Y., Kikuchi, K., Ruf, W., Sakuma, Y. Tsuchiya, E., and Miyagi, Y
    • Journal Title

      Br. J. Cancer

      Volume: 101 Issue: 12 Pages: 2023-2029

    • DOI

      10.1038/sj.bjc.6605406

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] HNF-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferase2009

    • Author(s)
      Koizume, S., Yokota, N., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Yoshida, A., Kameda, Y., Tsuchiya, E. and Miyagi, Y
    • Journal Title

      Mol. Cancer Res.

      Volume: 7 Issue: 12 Pages: 1928-1936

    • DOI

      10.1158/1541-7786.mcr-09-0372

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breast cancer phenotypes regulated by tissue factor-factor VII : possible therapeutic targets

    • Author(s)
      Koizume S, Miyagi Y. World. J. Ciln
    • Journal Title

      Oncol.

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 相乗的ICAM1 発現誘導の阻害は明細胞卵巣腫瘍の増殖を抑制する2013

    • Author(s)
      小井詰 史朗、伊藤 慎、吉原 光代、中村 圭靖、宮城 悦子、平原 史樹、高野 康雄、宮城 洋平
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣癌細胞により分泌される組織因子含有マイクロパーティクルの性質2013

    • Author(s)
      伊藤 慎、小井詰 史朗、吉原 光代、中村 圭靖、宮城 悦子、平原 史樹、高野 康雄、宮城 洋平
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 前立腺がんにおけるSPOP 遺伝子変異の頻度は本邦例と米国からの報告例の間に差を認めない2013

    • Author(s)
      宮城洋平、松隈 章一、吉原 光代、中村 圭靖、小井詰 史朗、岸田 健、横瀬 智之、高野 康雄
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 虚血性環境下相乗的に発現誘導されるICAM-1 は卵巣明細胞腫瘍の増殖を促進する2013

    • Author(s)
      小井詰 史朗、宮城 洋平
    • Organizer
      第11回 がんとハイポキシア研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 虚血性環境下相乗的に発現誘導されるCD69 は卵巣明細胞癌において細胞運動能、浸潤能を亢進する2013

    • Author(s)
      金山 知彦、小井詰 史朗、宮城 洋平
    • Organizer
      第11回 がんとハイポキシア研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 虚血性環境下相乗的に発現誘導されるCD69は卵巣明細胞癌において細胞運動能、浸潤能を亢進する2013

    • Author(s)
      金山 知彦、小井詰 史朗、宮城 洋平
    • Organizer
      第11回 がんとハイポキシア研究会
    • Place of Presentation
      仙台(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 虚血性環境下相乗的に発現誘導されるICAM-1は卵巣明細胞腫瘍の増殖を促進する2013

    • Author(s)
      小井詰 史朗、宮城 洋平
    • Organizer
      第11回 がんとハイポキシア研究会
    • Place of Presentation
      仙台(東北大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前立腺がんにおけるSPOP遺伝子変異の頻度は本邦例と米国からの報告例の間に差を認めない2013

    • Author(s)
      宮城洋平、松隈 章一、吉原 光代、中村 圭靖、小井詰 史朗、岸田 健、横瀬 智之、高野 康雄
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 卵巣癌細胞により分泌される組織因子含有マイクロパーティクルの性質2013

    • Author(s)
      伊藤 慎、小井詰 史朗、吉原 光代、中村 圭靖、宮城 悦子、平原 史樹、高野 康雄
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 相乗的ICAM1発現誘導の阻害は明細胞卵巣腫瘍の増殖を抑制する2013

    • Author(s)
      小井詰 史朗、伊藤 慎、吉原 光代、中村 圭靖、宮城 悦子、平原 史樹、高野 康雄
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] HIF2/Sp1/mTOR 相互作用によるICAM1 発現は虚血性環境における卵巣癌細胞生存を促進する2012

    • Author(s)
      小井詰 史朗、宮城 悦子、平原 史樹、吉原 光代、高野 康雄、宮城 洋平
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌で発現する異所性TFPI1 による癌細胞での接着阻害2012

    • Author(s)
      伊藤 慎、小井詰 史朗、高野 康雄、宮城洋平
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 甲状腺濾胞性腫瘍におけるRAS 遺伝子変異の頻度と臨床病理学的意義2012

    • Author(s)
      宮城洋平、吉田 明、松隈 章一、佐久間 裕司、小井詰 史朗、吉原 光代、岡本 直幸、横瀬 智之、近藤 哲夫、高野 康雄
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣明細胞癌において低酸素、低血清環境下HIF, Sp1 依存的に相乗的に発現誘導される遺伝子とその機能について2012

    • Author(s)
      小井詰 史朗、宮城 洋平
    • Organizer
      第9回 がんとハイポキシア研究会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] HIF2α/Sp1/mTOR interaction mediates a deacetylation-dependent FVII gene activation under serum deprived condition in ovarian cancer cells2012

    • Author(s)
      Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano, Wolfram Ruf, and Yohei Miyagi
    • Organizer
      The 103^<th> AACR annual meeting
    • Place of Presentation
      Chicago, IL
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell carcinoma (OCCA) phenotypes2012

    • Author(s)
      Tae Mogami, Naho Yokota, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Yuji Sakuma, Shiro Koizume, Mikiko Asai-Sato, Etsuko Miyagi, Fumiki Hirahara, and Yohei Miyagi
    • Organizer
      The 103^<th> AACR annual meeting
    • Place of Presentation
      Chicago, IL
    • Related Report
      2013 Final Research Report
  • [Presentation] HIF2a/Sp1/mTOR interaction mediates a deacetylation-dependent FVII gene activation under serum deprived condition in ovarian cancer cells.2012

    • Author(s)
      小井詰 史朗
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell carcinoma (OCCA) phenotypes2012

    • Author(s)
      最上 多恵
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF1/Sp1/mTOR相互作用によるICAM1発現は虚血性環境における卵巣癌細胞生存を促進する2012

    • Author(s)
      小井詰 史朗
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝細胞癌で発現する異所性TFPI1による癌細胞での接着阻害2012

    • Author(s)
      伊藤 慎
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 甲状腺濾胞性腫瘍におけるRAS遺伝子変異の頻度と臨床病理学的意義2012

    • Author(s)
      宮城洋平
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 卵巣明細胞癌において低酸素、低血清環境下HIF, Sp1依存的に相乗的に発現誘導される遺伝子とその機能について2012

    • Author(s)
      小井詰 史朗
    • Organizer
      第10回 がんとハイポキシア研究会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 卵巣明細胞癌においてHIF2α/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導するあ2011

    • Author(s)
      小井詰 史朗、宮城 悦子、平原 史樹、中村 圭靖、高野 康雄、宮城 洋平
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣明細胞腺癌で高発現するannexin A4の機能解析2011

    • Author(s)
      最上 多恵、横田 奈朋、伊藤 慎、吉原 光代、中村 圭靖、佐久間 裕司、小井詰 史朗、辻 祥太郎、宮城 悦子、平原 史樹、宮城 洋平
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌で見られるTF 及びTFPI1 の特異的な発現2011

    • Author(s)
      伊藤 慎、小井詰 史朗、中村 圭靖、高野康雄、宮城 洋平
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 浮遊状態のEGFR 変異陽性肺腺癌細胞は恒常的EGFR 活性化によりapoptosis を回避する2011

    • Author(s)
      佐久間 裕司、中村 圭靖、吉原 光代、小井詰 史朗、宮城 洋平
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素、低血清環境下HIF2α, Sp1 依存的に相乗的に発現誘導される遺伝子について2011

    • Author(s)
      小井詰 史朗、宮城 洋平
    • Organizer
      第9回 がんとハイポキシア研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣明細胞腺癌におけるANXA4 発現の解析2011

    • Author(s)
      最上 多恵、 横田 奈朋、 常住 淳、 辻祥太郎、 小井詰 史朗、佐藤 美紀子、宮城 悦子、宮城 洋平、平原 史樹
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypoxic activation of FVII gene in cancer cells mediated by interaction among HIF2α, Sp1, and HDAC42011

    • Author(s)
      Koizume S, Miyagi E, Hirahara F, Nakamura Y, Takano Y, Ruf W, Miyagi Y
    • Organizer
      The 102^<th> AACR annual meeting
    • Place of Presentation
      Orlando, FA
    • Related Report
      2013 Final Research Report
  • [Presentation] HIF2α-Sp1 相互作用が関与するFVII 遺伝子低酸素発現誘導2011

    • Author(s)
      小井詰 史朗、宮城 洋平
    • Organizer
      第8回がんとハイポキシア研究会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypoxic activation of FVII gene in cancer cells mediated by interaction among HIF2&#61537;, Sp1, and HDAC42011

    • Author(s)
      Koizume S
    • Organizer
      The 102th AACR annual meeting
    • Place of Presentation
      Orlando, FA
    • Related Report
      2011 Research-status Report
  • [Presentation] 卵巣明細胞癌においてHIF2alpha/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導する。

    • Author(s)
      小井詰 史朗
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 卵巣明細胞腺癌で高発現するannexin A4の機能解析

    • Author(s)
      最上 多恵
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝細胞癌で見られるTF及びTFPI1の特異的な発現

    • Author(s)
      伊藤 慎
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 浮遊状態のEGFR変異陽性肺腺癌細胞は恒常的EGFR活性化によりapoptosisを回避する。

    • Author(s)
      佐久間 裕司
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 低酸素、低血清環境下HIF2&#61537;, Sp1依存的に相乗的に発現誘導される遺伝子について

    • Author(s)
      小井詰 史朗
    • Organizer
      第9回 がんとハイポキシア研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 卵巣明細胞腺癌におけるANXA4発現の解析

    • Author(s)
      最上 多恵
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江
    • Related Report
      2011 Research-status Report
  • [Book] Ectopic synthesis of coagulation factor VII in breast cancer cells: Mechanisms, functional correlates, and potential for a new therapeutic target. Breast Cancer : Current and Alternative Therapeutic Modalities2011

    • Author(s)
      Koizume S, Miyagi Y
    • Publisher
      INTECH
    • Related Report
      2013 Final Research Report
  • [Book] Breast Cancer: Current and Alternative Therapeutic Modalities2011

    • Author(s)
      Koizume S
    • Total Pages
      16
    • Publisher
      INTECH
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://kcch.kanagawa-pho.jp/kccri/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 神奈川県立がんセンター臨床研究所

    • URL

      http://kcch.kanagawa-pho.jp/kccri/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://kcch.kanagawa-pho.jp/kccri/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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