| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Personalized peptide vaccine therapy must overcome several hurdles before being used as a general treatment for cancer. To this end, non-personalized multi-peptide cocktail vaccines that exhibit similar clinical effects without requiring time-consuming laboratory tests will be needed. In the present study, we have developed two new cocktail vaccines consisting of 20 peptides (KRM-20) and 10 peptides (KRM-10) for the treatment of prostate cancer and gastrointestinal cancers, respectively, by selecting the reactivity levels of their plasma IgG antibodies and cytotoxic T-lymphocyte-inducing activities. In addition, immunological analyses of blood samples of clinical trials suggested the immunological minimum effective doses.
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