Development of an early diagnostic system of human pancreatic cancer using metabolite profiling
| Project/Area Number |
23501296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Kobe University |
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Principal Investigator |
HATANO Naoya 神戸大学, 医学(系)研究科(研究院), 特命助教 (10332280)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メタボロミクス / プロテオミクス / がん |
|---|
| Research Abstract |
Cancer is leading cause of death in Japan. So, it is important to find patients with suspected cancer and take them to the hospital earlier. To find the patients, a low-cost, easy-to-use, and high-sensitive cancer screening method is required. Therefore, we proposed metabolite profiling using mass spectrometry as a cancer screening method. We established a method for human serum metabolomics. The method was applied to pancreatic cancer patients and healthy controls. Several metabolites were changed statistically significantly and contributed to the grouping. In order to understand how the metabolic changes occur, we also established the comparison proteomics method, which targeted the important metabolic enzyme group.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry2011
Author(s)
Kondo Y, Nishiumi S, Shinohara M, Hatano N, Ikeda A, Yoshie T, Kobayashi T, Shiomi Y, Iruno Y, Takenawa T, Azuma T, Yoshida M
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Journal Title
Biomark. Med
Volume: 5(4)
Issue: 4
Pages: 451-460
DOI
Related Report
Peer Reviewed
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[Journal Article] GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis2011
Author(s)
Ooi M, Nishiumi S, Yoshie T, Shiomi Y, Kohashi M, Fukunaga K, Nakamura S, Matsumoto T, Hatano N, Shinohara M, Irino Y, Takenawa T, Azuma T, Yohida M
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Journal Title
Inflamm. Res
Volume: 60(9)
Issue: 9
Pages: 831-840
DOI
Related Report
Peer Reviewed
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