| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Cancer is leading cause of death in Japan. So, it is important to find patients with suspected cancer and take them to the hospital earlier. To find the patients, a low-cost, easy-to-use, and high-sensitive cancer screening method is required. Therefore, we proposed metabolite profiling using mass spectrometry as a cancer screening method. We established a method for human serum metabolomics. The method was applied to pancreatic cancer patients and healthy controls. Several metabolites were changed statistically significantly and contributed to the grouping. In order to understand how the metabolic changes occur, we also established the comparison proteomics method, which targeted the important metabolic enzyme group.
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