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Systemic and integrated analysis of neuroendocrine tumor -Evaluation of disease entities and pathological diagnostic criteia

Research Project

Project/Area Number 23501301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnosis
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

MOTOI Noriko  公益財団法人がん研究会, その他部局等, 研究員 (70292878)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経内分泌腫瘍 / 神経内分泌癌 / 病理診断 / 神経内分泌分化 / 細胞増殖能 / 免疫染色 / miRNA / noncoding RNA / 組織分類 / ISH / miRNA発現解析
Research Abstract

The similarity and difference of tumor properties and prognosis among neuroendocrine tumor/carcinoma (NET/NEC) were examined systematically. The clinicopathological characteristisc of NEC including background information, prognosis, immunohistochemical examination of neuroendocrine markers, lineage specific markers and proliferation activity, as well as non-coding RNA, miRNA expression profile were evaluated. Results: The distribution of high grade and low grade NEC was different among origin of organ. Clinical characteristics and outcome also differ. It was confirmed that clinical outcome correlated well with tumor histology, degree of immunohistochemical NE marker and proliferating activity (Ki67 LI), independent to origin of organ. The miRNA expression profile differed between high grade and low grade NEC which included both lung and intestinal originated NEC. In conclusions, the similar diagnostic criteria of NEC defined by morphology with IHC can apply irrespective to the origin.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (105 results)

All 2014 2013 2012 2011

All Journal Article (30 results) (of which Peer Reviewed: 13 results,  Open Access: 2 results) Presentation (75 results) (of which Invited: 2 results)

  • [Journal Article] 免疫染色 腫瘍の鑑別に用いられる抗体 内分泌 神経内分泌2014

    • Author(s)
      元井 紀子
    • Journal Title

      病理と臨床

      Volume: 32(臨時増刊号) Pages: 226-230

    • Related Report
      2013 Final Research Report
  • [Journal Article] Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer.2014

    • Author(s)
      Ono, H., Motoi, N., Nagano, H et al.
    • Journal Title

      Cancer Medicine

      Volume: 3 MAR Issue: 3 Pages: 1-11

    • DOI

      10.1002/cam4.220

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease2014

    • Author(s)
      Kadota, K., Villena-Vargas, J., Yoshizawa, A., Motoi, N., Sima, C. S., Riely, G. J., Rusch, V. W., Adusumilli, P. S. and Travis, W. D.
    • Journal Title

      The American Journal of Surgical Pathology

      Volume: 38(4) Issue: 4 Pages: 448-460

    • DOI

      10.1097/pas.0000000000000134

    • Related Report
      2013 Final Research Report
  • [Journal Article] A subset of small cell lung cancer with low neuroendocrine expression and good prognosis : a comparison study of surgical and inoperable cases with biopsy2014

    • Author(s)
      Hamanaka, Wakako, Motoi, Noriko, Ishikawa, Shumpei, Ushijima, Masaru, Inamura, Kentaro, Hatano, Satoko, Uehara, Hirofumi, Okumura, Sakae, Nakagawa, Ken, Nishio, Makoto, Horai, Takeshi, Aburatani, Hiroyuki, Matsuura, Masaaki, Iwasaki, Akinori and Ishikawa, Yuichi
    • Journal Title

      Human Pathology

      Volume: 45(5) Pages: 1045-1056

    • Related Report
      2013 Final Research Report
  • [Journal Article] A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.2014

    • Author(s)
      Hamanaka, W, Motoi, N, Ishikawa, S., et al.
    • Journal Title

      Human Pathology

      Volume: 45 Issue: 5 Pages: 1045-1056

    • DOI

      10.1016/j.humpath.2014.01.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 免疫染色 腫瘍の鑑別に用いられる抗体 内分泌 神経内分泌2014

    • Author(s)
      元井紀子
    • Journal Title

      病理と臨床

      Volume: 32(臨時増刊) Pages: 226-230

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease.2014

    • Author(s)
      Kadota, K., Villena-Vargas, J., Yoshizawa, A, Motoi, N., et al.
    • Journal Title

      The American Journal of Surgical Pathology

      Volume: 38 Pages: 448-460

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 甲状腺腫瘍の病理2014

    • Author(s)
      元井紀子
    • Journal Title

      Japanese Journal of Diagnostic Imaging

      Volume: 32 Pages: 87-87

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Incidence of Pneumothorax in Advanced and/or Metastatic Soft Tissue Sarcoma Patients during Pazopanib Treatment.2014

    • Author(s)
      Nakano, K., Inagaki, L., Motoi, N., et al.
    • Journal Title

      Clinical oncology,

      Volume: 6 Pages: 357-357

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨肉腫の治療効果判定と問題点2014

    • Author(s)
      蛭田, 啓之, 町並, 陸生, 元井, 紀子
    • Journal Title

      病理と臨床

      Volume: 32(2) Pages: 156-160

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 【最新肺癌学-基礎と臨床の最新研究動向-】 肺癌の病理と病態 組織分類に関する最新知見2013

    • Author(s)
      元井 紀子 and 石川, 雄一
    • Journal Title

      日本臨床

      Volume: 71(増刊6 最新肺癌学) Pages: 165-169

    • Related Report
      2013 Final Research Report
  • [Journal Article] 甲状腺の病理2013

    • Author(s)
      元井 紀子
    • Journal Title

      都臨技会誌

      Volume: 41(4) Pages: 312-319

    • Related Report
      2013 Final Research Report
  • [Journal Article] Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes2013

    • Author(s)
      Ninomiya H, et al. 13人中4番目
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 8-8

    • DOI

      10.1186/1471-2407-13-8

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes2013

    • Author(s)
      Ninomiya, H., Kato, M., Sanada, M., Motoi N et al.
    • Journal Title

      BMC Cancer

      Volume: 13 Pages: 8-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気管浸潤と総頸動脈を3/4周取り囲み、切除不能と思われたCarcinoma showing thymus-like differentiation(CASTLE)の1例2013

    • Author(s)
      北野, 睦三, 杉谷, 巌, 元井紀子 他
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 30 Pages: 156-159

    • NAID

      130004600622

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Cytopathological review of patients that underwent thyroidectomies based on the diagnosis of papillary thyroid carcinoma by fine needle aspiration cytology but were later found to have benign tumors by histopathology.2013

    • Author(s)
      Kitano M, Sugitani I, Motoi N. et al.
    • Journal Title

      Surgery Today

      Volume: 43 Pages: 632-637

    • NAID

      10031176084

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pemetrexed and cisplatin for advanced non-squamous non-small cell lung cancer in Japanese patients: phase II study.2013

    • Author(s)
      Kawano, Y., Ohyanagi, F., Yanagitani, N. Motoi N. et al
    • Journal Title

      Anticancer research

      Volume: 33 Pages: 3327-3333

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sonographic findings in three cases of carcinoma showing thymus-like differentiation2013

    • Author(s)
      Yamamoto, Y., Yamada, K., Motoi, N., Fujiwara, Y., Toda, K., Sugitani, I., and Kohno, A.,
    • Journal Title

      J Clin Ultrasound

      Volume: Epub ahead of print Issue: 9 Pages: 574-578

    • DOI

      10.1002/jcu.21997

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytopathological review of patients that underwent thyroidectomies based on the diagnosis of papillary thyroid carcinoma by fine needle aspiration cytology but were later found to have benign tumors by histopathology.2013

    • Author(s)
      Kitano, M., Sugitani, I., Toda, K., Ikenaga, M., Motoi, N., Yamamoto, N., Hotomi, M., Fujimoto, Y., and Kawabata, K
    • Journal Title

      Surg Today

      Volume: 43 Issue: 6 Pages: 632-637

    • DOI

      10.1007/s00595-012-0362-y

    • NAID

      10031176084

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【神経内分泌腫瘍(NET)診断と治療のコンセンサス】 NETの診断と治療 肺のNET2012

    • Author(s)
      元井 紀子 and 石川, 雄一
    • Journal Title

      コンセンサス癌治療

      Volume: 11(3) Pages: 146-150

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study2012

    • Author(s)
      Thunnissen, E., Beasley, M. B., Borczuk, A. C., Brambilla, E., Chirieac, L. R., Dacic, S., Flieder, D., Gazdar, A., Geisinger, K., Hasleton, P., Ishikawa, Y., Kerr, K. M., Lantejoul, S., Matsuno, Y., Minami, Y., Moreira, A. L., Motoi, N., Nicholson, A. G., Noguchi, M., Nonaka, D., Pelosi, G., Petersen, I., Rekhtman, N., Roggli, V., Travis, W. D., Tsao, M. S., Wistuba, I., Xu, H., Yatabe, Y., Zakowski, M., Witte, B. and Kuik, D. J.
    • Journal Title

      Mod Pathol

      Volume: 25(12) Pages: 1574-1583

    • Related Report
      2013 Final Research Report
  • [Journal Article] NETの診断と治療 5)肺のNET2012

    • Author(s)
      元井紀子、石川雄一
    • Journal Title

      コンセンサス 癌治療

      Volume: 11 Pages: 146-150

    • Related Report
      2012 Research-status Report
  • [Journal Article] Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study.2012

    • Author(s)
      Thunnissen, E., Beasley, M. B., Borczuk, A. C., Brambilla, E.,. L., Motoi, N., et al.
    • Journal Title

      Mod Pathol

      Volume: 25 Issue: 12 Pages: 1574-1583

    • DOI

      10.1038/modpathol.2012.106

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 富細胞性軟部腫瘍の鑑別診断2012

    • Author(s)
      梶幸子、徳山宣、元井紀子、町並陸生、蛭田啓之
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 179-185

    • Related Report
      2012 Research-status Report
  • [Journal Article] Spindle cell lipoma(紡錘形細胞脂肪腫)の治療経験2012

    • Author(s)
      齊藤, 正徳, 松本, 誠一, 下地, 尚, 阿江, 啓介, 谷澤, 泰介, 澤村, 千草, 五木田, 茶舞, 早川, 景子, 中山, 隆之, 元井, 紀子
    • Journal Title

      臨床整形外科

      Volume: 47 Pages: 685-690

    • Related Report
      2012 Research-status Report
  • [Journal Article] 肺がんにはどんなものがあるか(病型・病期分類)2011

    • Author(s)
      元井紀子、石川雄一
    • Journal Title

      からだの科学

      Volume: 270 Pages: 22-26

    • Related Report
      2011 Research-status Report
  • [Journal Article] 肺に発生する神経内分泌腫瘍2011

    • Author(s)
      元井紀子、石川雄一
    • Journal Title

      病理と臨床

      Volume: 29 Pages: 444-450

    • Related Report
      2011 Research-status Report
  • [Journal Article] Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases2011

    • Author(s)
      Yoshizawa, A., N. Motoi, et al
    • Journal Title

      Modern pathology

      Volume: 24 Pages: 653-664

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 病理組織検体を用いたオーム研究 疾患関連分子同定への挑戦 トランスクリプトームによる病態解析.2011

    • Author(s)
      稲村健太郎, 元井紀子, 石川雄一
    • Journal Title

      病理と臨床

      Volume: 29 Pages: 522-528

    • Related Report
      2011 Research-status Report
  • [Journal Article] Clinicopathological findings of non-small-cell lung cancer with high serum progastrin-releasing peptide concentrations2011

    • Author(s)
      Kudo, K., F. Ohyanagi, Motoi N, et al.
    • Journal Title

      Lung Cancer

      Volume: 74 Pages: 401-404

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺癌の組織多様性とmiRNA発現様式2014

    • Author(s)
      元井 紀子, 長野, 裕子, 斎藤, 雄一, 宮内,栄作, 二宮, 浩範, 遠藤, 祐子, 木脇, 圭一, 杉浦, 善弥, Mahmut, Yasen and 石川, 雄一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA MALAT-1 の発現とKRAS変異の関連2014

    • Author(s)
      飯塚, 正明, 長野, 裕子, 野村, 起美恵, 元井紀子and 石川, 雄一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] 甲状腺腫瘤の病理2014

    • Author(s)
      元井 紀子
    • Organizer
      Japanese Journal of Diagnostic Imaging, 32(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] Significance of Morphological Heterogeneity of Lung Adenocarcinoma evaluated by FFPE-based miRNA profile, in Comparison with Genotype2014

    • Author(s)
      Motoi, N., Nagano, H., Miyauchi, E., Saito, Y., Sugiura, Y., Ninomiya, H., Kanda, H., Okumura, S. and Ishikawa, Y
    • Organizer
      103rd Annual Meeting United States and Canadian Academy of Pathology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Pulmonary Adenocarcinoma in Situ Is Not Simply a Precursor of Invasive Tumor : Evidence by Status of Smoking, Driver Mutations and Receptor Tyrosine Kinase Pathway Activation2014

    • Author(s)
      Sato, S., Motoi, N., Okumura, S., Tsuchida, M., Matsubara, O. and Ishikawa, Y
    • Organizer
      103rd Annual Meeting United States and Canadian Academy of Pathology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA MALAT-1の発現とKRAS変異の関連2014

    • Author(s)
      飯塚, 正明, 長野, 裕子, 野村, 起美恵, 元井紀子 他
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pulmonary Adenocarcinoma in Situ Is Not Simply a Precursor of Invasive Tumor: Evidence by Status of Smoking, Driver Mutations and Receptor Tyrosine Kinase Pathway Activation.2014

    • Author(s)
      Sato S, Motoi N, Okumura S et al.
    • Organizer
      103rd Annual Meeting United States and Canadian Academy of Pathology.
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Significance of Morphological Heterogeneity of Lung Adenocarcinoma evaluated by FFPE-based miRNA profile, in Comparison with Genotype.2014

    • Author(s)
      Motoi N., Nagano, H., et al.
    • Organizer
      103rd Annual Meeting United States and Canadian Academy of Pathology.
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経内分泌腫瘍の発生母地による組織像と生物学的性格の異同について/Variation and similarities of Histology and biologic behavior of neuroendocrine tumors among primary organ2013

    • Author(s)
      元井 紀子, 長野, 裕子, 野村, 起美恵, 吉本, 豊毅and 石川, 雄一
    • Organizer
      第72回日本癌学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between Morphologic Phenotype and Genotype of Lung Adenocarcinoma Based on a New IASLC/ATS/ERS Classification with Nuclear Grading2013

    • Author(s)
      Motoi, N., Sato, S., Saito, Y., Ninomiya, H., Takeuchi, K. and Ishikawa, Y.
    • Organizer
      (102nd Annual Meeting United States and Canadian Academy of Pathology) Modern Pathology 26(2s)
    • Related Report
      2013 Final Research Report
  • [Presentation] Morphological and Mucin profile of lung adenocarcinoma harboring driver mutation2013

    • Author(s)
      Motoi, N., Saito, Y., Miyauchi, E., Sato, S., Ninomiya, H. and Ishikawa, Y.
    • Organizer
      Journal of Thoracic Oncology, 8(Suppl.2)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA HOTAIR およびポリコーム遺伝子EZH2 の発現と予後の関連2013

    • Author(s)
      飯塚, 利彦, 長野, 裕子, 元井 紀子, 奥村, 栄 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 102(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA HOTAIR およびポリコーム遺伝子EZH2 の発現と予後の関連2013

    • Author(s)
      飯塚, 正明, 長野, 裕子, 元井 紀子, 奥村, 栄 and 石川 , 雄一
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] アスベスト関連肺線癌におけるmiRNA の網羅的発現プロファイリング2013

    • Author(s)
      馬合木特, 亜森, 二宮, 浩範, 元井 紀子 and 石川 , 雄一
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 副甲状腺癌の一例2013

    • Author(s)
      日野, るみ, 元井 紀子, 山田, 恵子, 戸田, 和寿, 杉谷, 巌 and 石川 , 雄一
    • Organizer
      第46回日本甲状腺外科学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Signet-ring follicular carcinoma の一例2013

    • Author(s)
      日野, るみ, 元井 紀子, 戸田, 和寿, 杉谷, 巌, 山田, 恵子, 川端, 一嘉 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 102(2)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺の高悪性度神経内分泌腫瘍をめぐる諸問題 診断から治療まで 細胞学的判別モデルを用いた肺原発大細胞神経内分泌癌と小細胞癌の鑑別2013

    • Author(s)
      星, 利良, 宝来, 威, 柳谷, 典子, 古田, 則行, 小松, 京子, 杉山, 裕子, 佐藤, 之俊, 元井 紀子 and 石川, 雄一
    • Organizer
      日本臨床細胞学会雑誌, 52(Suppl.2)
    • Related Report
      2013 Final Research Report
  • [Presentation] 大細胞神経内分泌癌の診断と治療方針 大細胞神経内分泌癌切除症例の臨床的検討と手術成績2013

    • Author(s)
      森, 彰平, 上原, 浩文, 後藤, 英典, 岡崎, 敏昌, 鮫島, 譲司, 松浦, 陽介, 中尾, 将之, 文, 敏景, 奥村, 栄, 中川, 健, 元井紀子 and 石川, 雄一
    • Organizer
      肺癌, 53(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] 当院での肺カルチノイド切除例の検2013

    • Author(s)
      後藤, 英典, 上原, 浩文, 森, 彰平, 鮫島, 譲司, 岡崎, 敏昌, 松浦, 陽介, 中尾, 将之, 文, 敏景, 中川, 健, 奥村, 栄, 工藤, 慶太, 柳谷, 典子, 堀池, 篤, 大柳, 文義, 宝来, 威, 西尾, 誠人, 元井 紀子 and 石川, 雄一
    • Organizer
      肺癌, 53(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] 末梢型小細胞肺がんは中枢型に比べ予後不良で、遺伝子発現プロファイルが異なる2013

    • Author(s)
      宮内, 栄作, 齋藤, 雄一, 二宮, 浩範, 元井 紀子, 西尾, 誠人, 奥村, 栄 and 石川, 雄一
    • Organizer
      肺癌, 53(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺および消化管に発生するカルチノイド腫瘍のmicroRNA 発現による起源・性質の解明2013

    • Author(s)
      吉本, 豊毅, 元井 紀子, 山本, 智理子, 牛嶋, 大, 松浦, 正明, 奥村, 栄, 山口, 俊晴, 深山, 正久 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 102(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] 小細胞肺癌切除例の検討2013

    • Author(s)
      岡崎, 敏昌, 上原, 浩文, 後藤, 英典, 森, 彰平, 鮫島, 譲司, 松浦, 陽介, 中尾, 将之, 文, 敏景, 中川, 健, 奥村, 栄, 工藤, 慶太, 柳谷, 典子, 堀池, 篤, 大柳, 文義, 宝来, 威, 西尾, 誠人, 元井紀子 and 石川, 雄一
    • Organizer
      肺癌, 53(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] DISTINCT CHARACTERISTICS OF SMALL CELL LUNG CANCER (SCLC) CORRELATE WITH CENTRAL OR PERIPHERAL ORIGIN - MICROARRAY ANALYSIS OF SNAP FROZEN TISSUE SAMPLES2013

    • Author(s)
      Miyauchi, E., Saito, Y., Ninomiya, H., Motoi, N., Nishio, M., Okumura, S. and Ishikawa, Y.
    • Organizer
      Journal of Thoracic Oncology, 8(Suppl.2)
    • Related Report
      2013 Final Research Report
  • [Presentation] Morphological and Mucin profile of lung adenocarcinoma harboring driver mutation.2013

    • Author(s)
      Motoi, N., Sato, S., Saito, Y., et al.,
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] DISTINCT CHARACTERISTICS OF SMALL CELL LUNG CANCER (SCLC) CORRELATE WITH CENTRAL OR PERIPHERAL ORIGIN - MICROARRAY ANALYSIS OF SNAP FROZEN TISSUE SAMPLES.2013

    • Author(s)
      Miyauchi, E., Saito, Y., Motoi N. et al.
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] IDENTIFICATION OF CPG ISLAND METHYLATOR PHENOTYPE PREDICTS THE PROGNOSIS OF SMALL CELL LUNG CANCER2013

    • Author(s)
      Saito Y, Miyauchi E, Motoi N. et al.
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] COPY NUMBER CHANGES IN CHROMOSOME 2P ARE UNIQUE EVENTS AMONG ALK FUSION POSITIVE LUNG ADENOCARCINOMAS.2013

    • Author(s)
      Ninomiya, H., Kato, M., Motoi N. et al.
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経内分泌腫瘍の発生母地による組織像と生物学的性格の異同について2013

    • Author(s)
      元井紀子 他
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression of long noncoding RNA HOTAIR and polycomb gene EZH2 is associated with prognosis in lung adenocarcinoma2013

    • Author(s)
      飯塚, 正明, 長野, 裕子, 元井 , 紀子, 他
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺および消化管に発生するカルチノイド腫瘍のmicroRNA発現による起源・性質の解明.2013

    • Author(s)
      吉本, 豊毅, 元井, 紀子, 山本, 智理子, 他
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression pattern of microRNAs in human asbestos-related lung adenocarcinomas.2013

    • Author(s)
      馬合木特, 亜森, 二宮, 浩範, 元井 , 紀子
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ALK肺癌の診断における病理医の役割.2013

    • Author(s)
      元井紀子、石川雄一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA HOTAIRおよびポリコーム遺伝子EZH2の発現と予後の関連.2013

    • Author(s)
      飯塚, 正明, 長野, 裕子, 野村, 起美恵, 元井紀子 他
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 末梢型小細胞肺がんは中枢型に比べ予後不良で、遺伝子発現プロファイルが異なる.2013

    • Author(s)
      宮内, 栄作, 齋藤, 雄一, 二宮, 浩範、元井紀子 他
    • Organizer
      第54回日本肺癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺の高悪性度神経内分泌腫瘍をめぐる諸問題 診断から治療まで 神経内分泌腫瘍の切除検体での確定診断と分子生物学的アプローチ.2013

    • Author(s)
      元井紀子
    • Organizer
      日本細胞学会秋季大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Signet-ring follicular carcinomaの一例2013

    • Author(s)
      日野, るみ, 元井 , 紀子
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺の高悪性度神経内分泌腫瘍をめぐる諸問題 診断から治療まで 細胞学的判別モデルを用いた肺原発大細胞神経内分泌癌と小細胞癌の鑑別2013

    • Author(s)
      星, 利良, 宝来, 威、元井紀子 他
    • Organizer
      第52回日本臨床細胞学会秋季大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 大細胞神経内分泌癌の診断と治療方針 大細胞神経内分泌癌切除症例の臨床的検討と手術成績2013

    • Author(s)
      森, 彰平, 上原, 浩文, 元井紀子 他
    • Organizer
      第54回日本肺癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 当院での肺カルチノイド切除例の検討2013

    • Author(s)
      後藤, 英典, 上原, 浩文, 元井紀子 他
    • Organizer
      第54回日本肺癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小細胞肺癌切除例の検討2013

    • Author(s)
      岡崎, 敏昌, 上原, 浩文, 元井紀子 他
    • Organizer
      第54回日本肺癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Carcinoid tumors of the lung and gastrointestinal tracts show common microRNA expression profiles, different from adeno- and small cell carcinomas, suggesting a common origin of systemic carcinoids2013

    • Author(s)
      Toyoki Yoshimoto, Noriko Motoi, Noriko Yamamoto, Masaru Ushijima, Masaaki Matsuura, Sakae Okumura, Toshiharu Yamaguchi, Masashi Fukayama, Yuichi Ishikawa
    • Organizer
      9th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Maui, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlation between Morphologic Phenotype and Genotype of Lung Adenocarcinoma Based on a New IASLC/ATS/ERS Classification with Nuclear Grading2013

    • Author(s)
      Motoi, N., Sato, S., Saito, Y., Ninomiya, H., Takeuchi, K., and Ishikawa,
    • Organizer
      102nd Annual Meeting United States and Canadian Academy of Pathology
    • Place of Presentation
      Baltimore, MD, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺および消化管に発生するカルチノイド腫瘍のmicroRNA発現による起源・性質の解明2013

    • Author(s)
      吉本豊毅、元井紀子、山本智理子、牛嶋大、松浦正明、奥村栄、山口俊晴、深山正久、石川雄一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA HOTAIR およびポリコーム遺伝子EZH2の発現と予後の関連2013

    • Author(s)
      飯塚利彦、長野裕子、元井紀子、石川雄一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] ALK肺癌の診断における病理医の役割2013

    • Author(s)
      元井紀子、石川雄一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] ALK肺癌の組織像と免疫染色によるスクリーニングの有用性について2013

    • Author(s)
      元井紀子、宮内栄作、斉藤雄一、二宮浩範、石川雄一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of histologic phenotype and genotype of lung adenocarcinoma2012

    • Author(s)
      元井 紀子, 佐藤, 征二郎, 齋藤, 雄一, 二宮, 浩範, 宮内, 栄作, 小野, 宏, 竹内, 賢吾, 長野, 裕子, 野村, 起美恵 and 石川, 雄一
    • Organizer
      日本癌学会総会記事, 71回
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌の遺伝子異常とIASLC/ATS/ERS 新分類に基づく病理組織亜型との関連2012

    • Author(s)
      元井 紀子, 佐藤, 征二郎, 小野, 宏, 斎藤, 雄一, 竹内, 賢吾, 稲村, 健太郎, 野村, 起美恵, 長野, 裕子, 冨樫, 由紀, 波多野, 郷子 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 101(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of Invasion Degree of Small Sized Lung Cancer Using Intra-Operative Frozen Section. in 101st Annual Meeting United States and Canadian Academy of Pathology2012

    • Author(s)
      Motoi, N., Hamanaka, W., Ohba, T., Karita, Shin, Ono, Hiroshi, Saito, Y., Sato, S., Inamura, K., Okumura, S. and Ishikawa, Y
    • Organizer
      2012
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] 小細胞肺癌に対する治療戦略 小細胞肺がんの層別化の試み 発生起源の再検討と発がん機構に注目して2012

    • Author(s)
      宮内, 栄作, 齋藤, 雄一, 二宮, 浩範, 元井 紀子, 西尾, 誠人, 奥村, 栄 and 石川, 雄一
    • Organizer
      肺癌, 52(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] 切除材料の病理学的検索にもとづく小細胞肺がんに対する外科治療の成績2012

    • Author(s)
      齋藤, 雄一, 宮内, 栄作, 佐藤, 征二郎, 小野, 宏, 二宮, 浩範, 稲村, 健太郎, 元井 紀子, 佐藤, 之俊 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 101(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌における長鎖noncoding RNA の発現と遺伝子変異、予後との相関2012

    • Author(s)
      飯塚, 利彦, 長野, 裕子, 齋藤, 雄一, 二宮, 浩範, 稲村, 健太郎, 元井 紀子 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 101(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of long non-coding RNAs in lung adenocarcinoma: Association with KRAS mutation and prognosis2012

    • Author(s)
      飯塚, 利彦, 長野, 裕子, 元井 紀子, 奥村, 栄 and 石川, 雄一
    • Organizer
      日本癌学会総会記事, 71回
    • Related Report
      2013 Final Research Report
  • [Presentation] KIF5B-ALK 陽性肺腺癌3 例の臨床病理学的検討2012

    • Author(s)
      二宮, 浩範, 宮内, 栄作, 齋藤, 雄一, 元井 紀子, 竹内, 賢吾 and 石川, 雄一
    • Organizer
      肺癌, 52(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] Long non-coding RNA HOTAIR affects cell adhesion- related gene expression in small cell lung cancer related to relapse2012

    • Author(s)
      小野, 宏, 長野, 裕子, 宮内, 栄作, 元井紀子, 奥村, 栄, 松浦, 正明, 廣瀬, 哲郎, 稲瀬, 直彦 and 石川, 雄一
    • Organizer
      日本癌学会総会記事, 71回
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺小細胞がんにおけるHOTAIR の発現は術後再発と関連している2012

    • Author(s)
      小野, 宏, 宮内, 栄作, 佐藤, 征二郎, 齋藤, 雄一, 元井 紀子, 廣瀬, 哲郎 and 石川, 雄一
    • Organizer
      日本病理学会会誌, 101(1)
    • Related Report
      2013 Final Research Report
  • [Presentation] 光機能性有機蛍光プローブによる微小肺がん検出の試み2012

    • Author(s)
      坂尾, 幸則, 奥村, 栄, 文, 敏景, 上原, 浩文, 中川, 健, 元井 紀子, 神田, 浩明, 石川, 雄一, 五来, 厚生, 中尾, 将之, 松浦, 陽介 and 岡崎, 敏昌
    • Organizer
      肺癌, 52(5)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺腺癌におけるStat3 発現 臨床病理学的特徴および変異遺伝子間の比較2012

    • Author(s)
      佐藤, 征二郎, 二宮, 浩範, 野村, 起美恵, 稲村, 健太郎, 元井 紀子, 奥村, 栄, 土田, 正則 and 石川, 雄一
    • Organizer
      日本癌治療学会誌, 47(3)
    • Related Report
      2013 Final Research Report
  • [Presentation] 小細胞肺がんの層別化の試み-発生起源の再検討と発がん機構に注目して-2012

    • Author(s)
      宮内栄作、斉藤雄一、二宮浩範、元井紀子、西尾誠人、奥村栄、石川雄一
    • Organizer
      第53回日本肺癌学会総会 ワークショップ
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of histologic phenotype and genotype of lung adenocarcinoma2012

    • Author(s)
      Motoi, N., Sato, S., Saito, Y., Ninomiya, H., Takeuchi, K., and Ishikawa,
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経内分泌腫瘍の病理 肺の神経内分泌腫瘍2012

    • Author(s)
      元井紀子、石川雄一
    • Organizer
      第55回日本病理学会関東支部会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 切除材料の病理学的検索にもとづく小細胞肺がんに対する外科治療の成績2012

    • Author(s)
      齋藤, 雄一, 宮内, 栄作, 佐藤, 征二郎, 小野, 宏, 二宮, 浩範, 稲村, 健太郎, 元井, 紀子, 佐藤, 之俊, 石川, 雄一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺腺癌の遺伝子異常とIASLC/ATS/ERS新分類に基づく病理組織亜型との関連2012

    • Author(s)
      元井 紀子、佐藤 征二郎、小野 宏、齋藤 雄一、稲村 健太郎、竹内 賢吾*、野村 起美恵、長野 裕子、富樫 由紀*、波多野 郷子*、石川 雄一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺腺癌における長鎖noncoding RNAの発現と遺伝子変異、予後との相関.2012

    • Author(s)
      飯塚, 利彦, 長野, 裕子, 齋藤, 雄一, 二宮, 浩範, 稲村, 健太郎, 元井, 紀子, 石川, 雄一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺小細胞がんにおけるHOTAIRの発現は術後再発と関連している2012

    • Author(s)
      小野, 宏, 宮内, 栄作, 佐藤, 征二郎, 齋藤, 雄一, 元井, 紀子, 廣瀬, 哲郎, 石川, 雄一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] EML4-ALK肺癌のtyrosine kinase下流パスウェイの発現状況による層別化.2012

    • Author(s)
      佐藤, 征二郎, 宮内, 栄作, 小野, 宏, 齋藤, 雄一, 二宮, 浩範, 稲村, 健太郎, 元井, 紀子, 竹内, 賢吾, 石川, 雄一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] FUS-CHOPキメラ遺伝子陽性で、悪性線維組織球腫様形態を示す後腹膜腫瘍の一例2012

    • Author(s)
      桐村, 進, 元井, 紀子, 神田, 浩明, 町並, 陸生, 石川, 雄一, 中村, 卓郎, 吉川, 慎一, 古賀, 倫太郎
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Hepatoid giant cell tumor of tendon sheathの一例2012

    • Author(s)
      吉本, 豊毅, 元井, 紀子, 神田, 浩明, 石川, 雄一, 町並, 陸生, 谷沢, 泰介, 下地, 尚, 松本, 誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Assessment of Invasion Degree of Small Sized Lung Cancer Using Intra-Operative Frozen Section.2012

    • Author(s)
      Motoi, N., Hamanaka, W., Ohba, T., Karita, Shin, Ono, Hiroshi, Saito, Y., Sato, S., Inamura, K., Okumura, S., and Ishikawa, Y
    • Organizer
      101st Annual Meeting United States and Canadian Academy of Pathology.
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経内分泌腫瘍の病理-肺と他臓器発生例の比較検討2011

    • Author(s)
      元井紀子
    • Organizer
      第15回日本内分泌病理学会学術総会
    • Place of Presentation
      東京都平河町、都道府県会館
    • Related Report
      2011 Research-status Report
  • [Presentation] Morphologic diversity of ALK-altered lung adenocarcinoma; no strong correlation with chimeric variants2011

    • Author(s)
      Noriko Motoi, Wakako Hamanaka, Takehito Oba, et al.
    • Organizer
      14th World Conference on Lung Cancer
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of histologic accuracy on diagnosis and invasion of small-sized lung cancer using intra-operative frozen section2011

    • Author(s)
      Noriko Motoi, Wakako Hamanaka, Takehito Oba, et al.
    • Organizer
      14th World Conference on Lung Cancer
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2011 Research-status Report
  • [Presentation] Reproducibility of invasion in pulmonary adenocarcinoma. An international interobserver study.2011

    • Author(s)
      Thunnissen, E., M. Beasly, Motoi, N. et al.
    • Organizer
      14th World Conference on Lung Cancer
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2011 Research-status Report
  • [Presentation] 肺癌における術中迅速診断の有用性と問題点2011

    • Author(s)
      元井紀子, 濱中和嘉子, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 諸臓器に発生する神経内分泌腫瘍の臨床病理学的特徴と細胞分化マーカーの発現解析2011

    • Author(s)
      元井紀子, 長野裕子, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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