Development of novel lead compounds with enhancing effect on ALA-based photodynamic therapy
| Project/Area Number |
23501305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Kanazawa University |
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Principal Investigator |
ENDO YOSHIO 金沢大学, がん進展制御研究所, 准教授 (30211783)
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| Co-Investigator(Renkei-kenkyūsha) |
UTO Yoshihiro 徳島大学, 工学部, 准教授 (20304553)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 光線力学的療法 / PDT / 5-アミノレブリン酸 / 5-ALA / トランスポーター / 効果増強剤 / 光線力学療法 / ALA / PEPT1 / ABCG2 / 増強剤 / 耐性細胞 |
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| Research Abstract |
Protoporphyrin IX (PpIX)-dependent photodynamic diagnosis (PDD) and therapy (PDT) using 5-aminolevulinic acid (ALA-PDD and ALA-PDT) are widely recognized novel therapeutic strategies for the treatment of various cancers.Previously, we demonstrated that the balance between the influx of ALA through the transporter PEPT1 and the efflux of intracellular PpIX through the ABC transporter ABCG2 determines the sensitivity of cancer cells to ALA-PDT. Recently, we found that the Schiff base derivative TX-816 could significantly increase the effect of ALA-PDT. The ability of TX-816 to enhance the efficacy of ALA-PDT was markedly stronger than that of dipyridamole, which inhibits ABCG2 and equilibrative nucleoside transporters. Furthermore, TX-816 could recover the sensitivity to ALA-PDT in cancer cells with acquired resistance. These results indicate TX-816 is a potent lead compound to develop an ALA-PDT sensitizer.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.2013
Author(s)
Yuichiro Hagiya, Hideo Fukuhara, Kentaro Matsumoto, Yoshio Endo, Motowo Nakajima, Tohru Tanaka, Ichiro Okura, Atsushi Kurabayashi, Mutsuo Furihata, Keiji Inoue, Taro Shuin, Shun-ichiro Ogura
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Journal Title
Photodiagnosis and Photodynamic Therapy
Volume: 印刷中
Issue: 3
Pages: 288-295
DOI
Related Report
Peer Reviewed
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[Journal Article] Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro2012
Author(s)
Hagiya Y, Endo Y, Yonemura Y, Takahashi K, Ishizuka M, Abe F, Tanaka T, Okura I, Nakajima M, Ishikawa T, Ogura S
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Journal Title
Photodiagnosis Photodyn Ther
Volume: 9(3)
Issue: 3
Pages: 204-214
DOI
Related Report
Peer Reviewed
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[Presentation] 発育鶏卵を用いた5-aminolevulinic acid およびTin Chlorin e6 の超音波増感活性と薬物動態の評価2013
Author(s)
宇都義浩,玉谷 大,河井智仁,遠藤良夫,大久保敬,中西郁夫,石塚昌宏,田中 徹,口池大輔,久保健太郎,乾 利夫, 堀 均
Organizer
第17回バイオ治療法研究会
Place of Presentation
福岡県、福岡大学病院 福大メディカルホール
Year and Date
2013-12-07
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