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Discovery of a new antitumor drug targeting the tumor-stromal cell interactions

Research Project

Project/Area Number 23501321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical oncology
Research InstitutionMicrobial Chemistry Research Foundation

Principal Investigator

KAWADA Manabu  公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 主席研究員 (20300808)

Co-Investigator(Renkei-kenkyūsha) INOUE Hiroyuki  公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 (50601548)
AMEMIYA Masahide  公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 (10232000)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌 / 生理活性物質 / 間質
Research Abstract

For creation of a new antitumor drug targeting the interactions between tumor cells and the surrounding stromal cells in tumor tissues, we have developed coculture systems of both cells and searched for compounds that modulate the interactions. As a result, we have isolated a new compound, intervenolin, from the culture broth of actinomyces. Intervenolin inhibits the growth of human gastric and colorectal cancer cell lines when cocultured with the respective organ-derived stromal cells more strongly than that of the cancer cells cultured alone. Intervenolin shows antitumor effects against xenograft models of human gastric and colorectal cancer cells in vivo.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.2013

    • Author(s)
      Kawada, M., Inoue, H., Ohba, S., Hatano, M., Amemiya, M., Hayashi, C., Usami, I., Abe, H., Watanabe, T., Kinoshita, N., Igarashi, M., Masuda, T., Ikeda, D., and Nomoto, A.
    • Journal Title

      J. Antibiot.

      Volume: 66 Issue: 9 Pages: 543-548

    • DOI

      10.1038/ja.2013.42

    • NAID

      10031201650

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.2013

    • Author(s)
      Abe, H., Kawada, M., Inoue, H., Ohba, S., Nomoto, A., Watanabe, T., and Shibasaki M.
    • Journal Title

      Org. Lett.

      Volume: 15 Issue: 9 Pages: 2124-2127

    • DOI

      10.1021/ol400587a

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities.2013

    • Author(s)
      Abe, H., Kawada, M., Inoue, H., Ohba, S., Masuda, T., Hayashi, C., Igarashi, M., Nomoto, A., Watanabe, T., and Shibasaki M.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 36 Pages: 7608-7617

    • DOI

      10.1016/j.tet.2013.05.033

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of tumor-stromal cell interactions: a new anti-tumor strategy targeting the tumor microenvironment.2013

    • Author(s)
      Kawada, M., Sakamoto, S., and Nomoto, A.
    • Journal Title

      For. Immunopathol. Dis. Ther.

      Volume: 4 Issue: 1 Pages: 53-62

    • DOI

      10.1615/forumimmundisther.2013008317

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Decalpenic acid induces early osteoblastic markers in pluripotent mesenchymal cells via activation of retinoic acid receptor gamma.2012

    • Author(s)
      Sakamoto, S., Kojima, F., Momose, I., Kawada, M., Adachi, H., and Nishimura, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 422 Issue: 4 Pages: 751-757

    • DOI

      10.1016/j.bbrc.2012.05.075

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants2012

    • Author(s)
      Kimura KI, Sakamoto Y, Fujisawa N, Uesugi S, Aburai N, Kawada M, Ohba SI, Yamori T, Tsuchiya E, Koshino H
    • Journal Title

      Bioorg Med Chem

      Volume: 20(12) Issue: 12 Pages: 3887-3897

    • DOI

      10.1016/j.bmc.2012.04.025

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] がんと間質の共培養スクリーニングから発見した抗ピロリ菌活性を有する新規抗がん物質Intervenolin2013

    • Author(s)
      川田学、坂本修一、雨宮昌秀、増田徹、野本明男
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規化合物NBRI16716Aによるがんー間質相互作用の制御2012

    • Author(s)
      川田学、坂本修一、雨宮昌秀、増田徹、野本明男
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] がんと間質の共培養スクリーニングから発見した抗ピロリ菌活性を有する新規抗がん物質Intervenolin

    • Author(s)
      川田学、坂本修一、雨宮昌秀、増田徹、野本明男
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gastric stromal cells upregulate gastric tumor cell growth through IL-6

    • Author(s)
      川田学、坂本修一、雨宮昌秀、増田徹、野本明男
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.bikaken.or.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 公益財団法人微生物化学研究会

    • URL

      http://www.bikaken.or.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 公益財団法人微生物化学研究会

    • URL

      http://www.bikaken.or.jp/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.bikaken.or.jp/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013

    • Inventor(s)
      川田学、井上裕幸、大庭俊一、波多野和樹、阿部光、林千草、渡辺匠、五十嵐雅之
    • Industrial Property Rights Holder
      公益財団法人微生物化学研究会
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-035731
    • Filing Date
      2013-02-26
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013

    • Inventor(s)
      川田学、井上裕幸、大庭俊一、波多野和樹、阿部光、他3名
    • Industrial Property Rights Holder
      公益財団法人微生物化学研究会
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-035731
    • Filing Date
      2013-02-26
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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