| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, it was revealed that the gene has the tumor suppressive function in gallbladder cancer as well as in gastric cancer, and that gene influences expression of genes related to inflammation and immune system. Moreover, the result of this study suggests that PSCA gene is suppressed in gastric epithelial cells by a T allele of single nucleotide polymorphism (SNP) rs2294008 which recruits a suppressive transcription factor YY1 to the PSCA promoter, predisposing to gastric cancer. In addition, exploration of novel expression sites of the gene detected PSCA in the gallbladder epithelium, islets of the pancreas and neuronal cells in the brain. Although the function of PSCA protein is far from being thoroughly explored at molecular level, new and important insight was obtained in this study.
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