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An analysis of the mechanisms of loss of immune system in T cell induced by p53 gene instability after irradiation at a young age

Research Project

Project/Area Number 23510070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OKAZAKI Ryuji  産業医科大学, 産業生態科学研究所, 教授 (50309960)

Co-Investigator(Kenkyū-buntansha) OOTSUYAMA Akira  産業医科大学, 医学部, 教育教授 (10194218)
YOSHIDA Yasuhiro  産業医科大学, 医学部, 准教授 (10309958)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords若年時放射線被曝 / p53 / NF-κB / 炎症 / 若年時被曝 / T細胞 / p53 / 遺伝子不安定性 / 免疫能低下 / 放射線被曝 / 遺伝的不安定性
Research Abstract

Radio-sensitivity is highest during young age, and radiation effects are different at old age depending on the age at the time of exposure.
In this study, we exposed p53+/- mice to a whole-body dose of 3 Gy at 8, 17, 30 and 41 weeks of age, and evaluated NF-kB and the related genes of the spleen at 56 weeks of age. CDK2, p21, phospho (p)-IKKa, p-IkBa, p-p65, NF-kB and ATP were elevated only in the mice that were given a whole-body dose of 3 Gy at 8 weeks of age. Taken together, irradiation at a young age might elevate NF-kB and ATP at old age. We suggest that the elevation of NF-kB means the continuation of inflammation and is related to the induction of cancer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (22 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] The p53 dependent delayed effects of radiation varied at the timing of irradiation in p53^<+/-> mice2014

    • Author(s)
      Okazaki R, Ootsuyama A
    • Journal Title

      J Radiat Res (Tokyo)

      Volume: 55(1) Pages: 25-31

    • Related Report
      2013 Final Research Report
  • [Journal Article] The p53 dependent delayed effects of radiation varied at the timing of irradiation in p53+/- mice2014

    • Author(s)
      Okazaki R, Ootsuyama A
    • Journal Title

      J Radiat Res

      Volume: 55 Issue: 1 Pages: 25-31

    • DOI

      10.1093/jrr/rrt083

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 職業における放射線障害の歴史2014

    • Author(s)
      岡﨑 龍史
    • Journal Title

      産業医科大学雑誌

      Volume: 36 Pages: 27-27

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How Occupational Health Can Contribute at a Disaster and What Should Prepare for the Future? -Lessons Learned through Support Activities of a Medical School at the Fukushima Daiichi Nuclear Power Plant in Summer 20112013

    • Author(s)
      Mori K, Tateishi, S Hiraoka, K, Kubo T, Okazaki R, Suzuki K, Kobayashi Y, Kohno K.
    • Journal Title

      Journal of Occupational Health

      Volume: 55 Pages: 6-10

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本における放射線に関する法令2013

    • Author(s)
      岡﨑 龍史
    • Journal Title

      産業医科大学雑誌

      Volume: 35 Pages: 85-89

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集:福島第一原子力発電所事故後の放射線対策と動向2013

    • Author(s)
      岡﨑 龍史
    • Journal Title

      日本臨床

      Volume: 72 Pages: 236-239

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Establishment of MSP for the mouse p53 gene2011

    • Author(s)
      Okazaki R, Ootsuyama A, Yoshida Y, Norimura T
    • Journal Title

      Molecular Biology International

      Volume: 2011 Pages: 938435-938435

    • DOI

      10.4061/2011/938435

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 震災からの復興時に必要な健康管理の知識,解説III、放射線障害に対する正しい知識2011

    • Author(s)
      岡崎龍史
    • Journal Title

      労働衛生コンサルタント

      Volume: 31 Pages: 22-28

    • Related Report
      2011 Research-status Report
  • [Journal Article] 放射線被ばくを考える-放射線に関する一般的な話題(総論)を中心に-2011

    • Author(s)
      岡崎龍史
    • Journal Title

      福岡県医報

      Volume: 1424 Pages: 4-4

    • Related Report
      2011 Research-status Report
  • [Journal Article] 郡山市内医師と一般市民の福島第一原発事故後の放射線に対する意識の違い(アンケート調査結果から)2011

    • Author(s)
      岡崎龍史、大津山彰、阿部利明、久保達彦、太神和廣、菊池辰夫、菊池信太郎、佐久間秀人
    • Journal Title

      福島県医師会報

      Volume: 73 Pages: 38-41

    • Related Report
      2011 Research-status Report
  • [Journal Article] 医師が心得ておくべき放射線被ばくの基礎知識-福島第一原発事故を踏まえて-2011

    • Author(s)
      岡崎龍史
    • Journal Title

      相模原市医師会報

      Volume: 48 Pages: 735-736

    • Related Report
      2011 Research-status Report
  • [Presentation] Pig-A 遺伝子をリポーターとして用いたin vitro突然変異検出試験の高線量被曝環境作業者の健康影響評価応用への検討2013

    • Author(s)
      大津山彰、岡﨑龍史、猪狩和之
    • Organizer
      第31回産業医科大学学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 低線量放射線照射後のメタボローム解析と血算の変動2013

    • Author(s)
      岡﨑龍史、大津山彰、鈴木光浩
    • Organizer
      第50回放射線影響懇話会
    • Place of Presentation
      佐賀
    • Year and Date
      2013-07-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Irradiation of mice at a young age induces immune modulation of spleen cells in old age2013

    • Author(s)
      Okazaki R, Song Y, Yoshida Y, Kanazawa T, Ootsuyama A
    • Organizer
      59th Annual Radiation Research Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 東京電力福島第一原発で復旧作業参加企業に提供したアクションチェックリスト利用状況について2013

    • Author(s)
      平岡晃、立石清一郎、久保達彦、深井航太、鈴木克典、岡﨑龍史、森晃爾
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      ひめぎんホール、愛媛
    • Related Report
      2013 Annual Research Report
  • [Presentation] Irradiation of mice at a young age induces immune modulation of spleen cells in old age2013

    • Author(s)
      Okazaki R, Song Y, Yoshida Y, Kanazawa T, Ootsuyama A.
    • Organizer
      59th Annual Radiation Research Meeting
    • Place of Presentation
      Hilton New Orleans Riverside Hotel, New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 福島県内外の一般市民および医師の福島第一原子力発電所事故後の放射線被曝に対する意識調査2013

    • Author(s)
      岡﨑龍史、大津山彰、阿部利明、久保達彦
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森、青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] Irradiation at young age induces immonomodulation on splenocytes in old age mice2012

    • Author(s)
      宋媛、岡﨑龍史、金澤保、吉田安宏
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学 学術交流会館(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] 放射線適応応答におけるp53の役割2012

    • Author(s)
      岡﨑龍史
    • Organizer
      第55回放射線影響学会
    • Place of Presentation
      東北大学 川内北キャンパス(仙台)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The differences in delayed mutations of the p53 gene after irradiation at the various ages2012

    • Author(s)
      Okazaki R, Ootsuyama A
    • Organizer
      58th Annual Radiation Research Meeting
    • Place of Presentation
      Rio Mar Resort and Spa (San Juan, Puerto Rico)
    • Related Report
      2012 Research-status Report
  • [Presentation] Dynamics of Delayed p53 Mutations in Mice2012

    • Author(s)
      Okazaki R
    • Organizer
      EPS Montreal Int. Geography & Environ. Forum
    • Place of Presentation
      Holiday Inn Select (Canada)
    • Related Report
      2011 Research-status Report
  • [Presentation] Dynamics of Delayed p53 Mutation after Irradiation2011

    • Author(s)
      Okazaki R, Ootsuyama A, et al.
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Palace of Culture and Science (Poland)
    • Related Report
      2011 Research-status Report
  • [Presentation] Dynamic expression of p53 after irradiation2011

    • Author(s)
      Ootsuyama A, Okazaki R, Norimura T
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Palace of Culture and Science (Poland)
    • Related Report
      2011 Research-status Report
  • [Presentation] 照射週齢の違いによる遅延型突然変異におけるp53遺伝子の解析2011

    • Author(s)
      岡崎龍史、大津山彰
    • Organizer
      第54回放射線影響学会
    • Place of Presentation
      神戸商工会議所会館 (神戸)
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児科医が心得ておくべき放射線被ばくの基礎知識―原発事故の影響を中心に-2011

    • Author(s)
      岡崎龍史
    • Organizer
      平成23年度福島県小児科医会総会(招待講演)
    • Place of Presentation
      郡山ビューホテル ( 福島)
    • Related Report
      2011 Research-status Report
  • [Presentation] 園医・校医・かかりつけ医が心得ておくべき放射線被ばくの基礎知識2011

    • Author(s)
      岡崎龍史
    • Organizer
      郡山医師会(招待講演)
    • Place of Presentation
      郡山市医療介護病院 ( 福島)
    • Related Report
      2011 Research-status Report
  • [Presentation] 福島第一原発事故による放射線影響の今後の予測―疫学あるいは実験データから考えられること-2011

    • Author(s)
      岡崎龍史
    • Organizer
      平成23年度日本医師会(招待講演)
    • Place of Presentation
      大分県医師会館 ( 大分)
    • Related Report
      2011 Research-status Report
  • [Presentation] 医師が心得ておくべき放射線被ばくの基礎知識―福島第一原発事故を踏まえて―2011

    • Author(s)
      岡崎龍史
    • Organizer
      第392回相模医学会(招待講演)
    • Place of Presentation
      相模原市あじさい会館 ( 相模原)
    • Related Report
      2011 Research-status Report
  • [Presentation] 福島第一原発事故による放射線影響の今後の予測―原爆及びチェルノブイリと比較して―2011

    • Author(s)
      岡崎龍史
    • Organizer
      北九州女性医師の会2011(招待講演)
    • Place of Presentation
      ステーションホテル小倉 ( 小倉)
    • Related Report
      2011 Research-status Report
  • [Presentation] Fukushima is not Chernobyl2011

    • Author(s)
      Okazaki R
    • Organizer
      UOEH international symposium(招待講演)
    • Place of Presentation
      ヒルトン福岡シーホーク ( Fukuoka)
    • Related Report
      2011 Research-status Report
  • [Presentation] 一般向け緊急被曝ガイド2011

    • Author(s)
      岡崎龍史、大津山彰
    • Organizer
      第48回放射線影響懇話会
    • Place of Presentation
      くまもと県民交流館パレア ( 熊本)
    • Related Report
      2011 Research-status Report
  • [Presentation] 低線量放射線照射後のメタボローム解析と血算の変動

    • Author(s)
      岡﨑龍史、大津山彰、鈴木光浩
    • Organizer
      第50回放射線影響懇話会
    • Place of Presentation
      佐賀大学臨床小講堂、佐賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pig-A遺伝子をリポーターとして用いたin vitro突然変異検出試験の高線量被曝環境作業者の健康影響評価応用への検討

    • Author(s)
      大津山彰、岡﨑龍史、猪狩和之
    • Organizer
      第31回産業医科大学学会総会
    • Place of Presentation
      産業医科大学ラマティーニホール、北九州
    • Related Report
      2013 Annual Research Report
  • [Book] 図説放射線学入門-基礎から学ぶ緊急被曝ガイド-2012

    • Author(s)
      岡崎龍史
    • Total Pages
      120
    • Publisher
      医療科学社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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