| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Although PNMPP did not show effects on the basal secretion of FSH and LH from pituitary cells of immature male rats, secretion of both hormones stimulated by GnRH were decreased by adding PNMPP. PNMPP stimulated testosterone secretion from Leydig cells and enhanced the response to the hCG in vitro. PNMMPP was proved to have anti-androgenic effects in vivo using castrated immature male rats supplemented with testosterone.
PNMC and PNP stimulated proliferation of normal mammary epithelial cells in mice, but did not for cells derived from mammary tumor of both mice and human. Nitrophenols failed to show effects on sexual differentiation of the brain in the rat.
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