The role of prenatal exposure to endocrine disruptors on immune and neural systems.
| Project/Area Number |
23510074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | phytoestrogen / Th1/Th2 / macrophages / 植物エストロゲン / M1/M2 / 内分泌かく乱化学物質 / マクロファージ / 大豆 / ビスフェノールＡ / ヘルパーT細胞 / ヘルパーＴ細胞 |
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| Research Abstract |
In order to clarify Th cell differentiation and M1 and M2 markers of macrophages, mice given soy bean-free (SF) or normal (N) chows for several generations were immunized with KLH. BPA was given orally 1 day before immunization. Mice were again immunized 14 days after first immunization, and splenocytes were taken 7 days after challenge. Peritoneal macrophages were collected from non-immunized mice.
Component(s) of soy beans inhibit Th1 differentiation. BPA influences additively on the inhibitory effects of the soy bean component(s). In addition, M1 and M2 markers and cytokine profiles of macrophages from SF and N were not completely parallel with the data of Th differentiation, although they indicate that component(s) of soy beans might induce M2 differentiation. Further study is necessary to clarify this mechanism.
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Report
(4 results)
Research Products
(15 results)
