| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In order to clarify Th cell differentiation and M1 and M2 markers of macrophages, mice given soy bean-free (SF) or normal (N) chows for several generations were immunized with KLH. BPA was given orally 1 day before immunization. Mice were again immunized 14 days after first immunization, and splenocytes were taken 7 days after challenge. Peritoneal macrophages were collected from non-immunized mice.
Component(s) of soy beans inhibit Th1 differentiation. BPA influences additively on the inhibitory effects of the soy bean component(s). In addition, M1 and M2 markers and cytokine profiles of macrophages from SF and N were not completely parallel with the data of Th differentiation, although they indicate that component(s) of soy beans might induce M2 differentiation. Further study is necessary to clarify this mechanism.
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