| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
There have been many concerns regarding the possible adverse effects of thyroid hormone-disrupting chemicals such as PBDEs. Our results suggested that thyroid hormone-disrupting actions (agonism of antagonism) of PBDEs differ among target tissues or species. Our in vivo studies demonstrated that neonatal exposure to T3 altered the expression of some hepatic genes, including TRa2 and Ugt1A1 in the adult stage, suggesting that neonatal exposure to thyroid hormone-disrupting chemicals may affect the gene expression profile of the thyroid axis in adulthood.
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