toxicolgical role of Zn2+ in cell death induced by chemical stress
| Project/Area Number |
23510078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OYAMA Yasuo 徳島大学, 大学院ソシオ・アーツ・アンド・サイエンス研究部, 教授 (80214229)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 細胞毒性 / 亜鉛イオン / 亜鉛 / 国際情報交換 / 酸化ストレス |
|---|
| Research Abstract |
The toxicological role of Zn2+ in cell death induced by chemical compounds was examined in this study. Micromolar concentrations of Zn2+ potentiated the cytotoxicity of hydrogen peroxide while the chelator of intracellular Zn2+ diminished it. This result suggests an involvement of Zn2+ in the cell death induced by hydrogen peroxide. The chemical compounds that induced the increase in intracellular Zn2+ concentration potentiated the cytotoxicity of hydrogen peroxide. However, the increase in intracellular Zn2+ concentration by the chemical compounds elevated the cellular content of nonprotein thiols, cytoprotective substances. It is suggested that Zn2+ exerts reciprocal actions, cytoprotective and cytotoxic, on the cell death under certain conditions.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Effect of triclocarban on membrane potential of rat thymocytes : Assessment with bis-(1,3-dibutylbarbituric acid) trimethine oxonol2013
Author(s)
Yuanzhi Sun, Molomjamts Enkhjargal, Aya Sugihara, Saki Yamada, Xiaohui Chen, Yukari Miura, Eri Fukunaga, Masaya Satoh, Yasuo Oyama
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Journal Title
Natural Science Research
Volume: Vol. 27, No. 4
Pages: 51-57
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Peer Reviewed
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[Journal Article] NOR-3, a donor of nitric oxide, increases intracellular Zn^<2+> concentration and decreases cellular thiol content : A model experiment using rat thymocytes, FluoZin-3, and 5-chloromethylfluorescein2011
Author(s)
Soya Harada, Chiharu Kubota, Natsuho Kitano, Takuya Kawanai, Kazuki Koizumi, Yasuo Oyama, Akio Kinazaki, Shiro Ishida and Yoshiro Okano
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Journal Title
Natural Science Research
Volume: Vol. 25, No. 1
Pages: 1-6
NAID
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Related Report
Peer Reviewed
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