| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The purpose of this work was to evaluate the modification of histone by arsenic compounds, and to elucidate the meanings of these modifications.
Inorganic arsenite [iAs(III)] induced phosphorylation and methylation of histone H3, and phospho-histone H3 was observed as a punctual signals in specific region. Furthermore, we fund phospho-histone H3 was localized in the promoter region of FOS and EGR1, which were induced by iAs(III). These results suggested that the modification of histone changes chromatin structure and then induces gene expression.
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