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Variety of histone modifications by arsenic compounds, and the meanings of these modifications.

Research Project

Project/Area Number 23510082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTeikyo University

Principal Investigator

SUZUKI Toshihide  帝京大学, 薬学部, 准教授 (60256055)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsヒ素化合物 / エピジェネティクス / ヒストン修飾 / 遺伝子誘導 / 細胞毒性
Outline of Final Research Achievements

The purpose of this work was to evaluate the modification of histone by arsenic compounds, and to elucidate the meanings of these modifications.
Inorganic arsenite [iAs(III)] induced phosphorylation and methylation of histone H3, and phospho-histone H3 was observed as a punctual signals in specific region. Furthermore, we fund phospho-histone H3 was localized in the promoter region of FOS and EGR1, which were induced by iAs(III). These results suggested that the modification of histone changes chromatin structure and then induces gene expression.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2015 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines2012

    • Author(s)
      Suzuki T, Kita K, Ochi T.
    • Journal Title

      J Appl. Toxicol.

      Volume: 33 Issue: 8 Pages: 746

    • DOI

      10.1002/jat.2724

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 3価無機ヒ素[iAs(III)]による遺伝子発現に関与する転写因子とヒストンH3修飾の関連性2015

    • Author(s)
      渡邉 裕史、鈴木 俊英、北 加代子、越智 崇文
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸サンボーホール
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3価無機ヒ素[iAs(III)]によるヒストンH3の修飾2012

    • Author(s)
      鈴木俊英、北加代子、越智崇史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 3価無機ヒ素[iAs(III)]による、FOSおよびEGR1遺伝子プロモーター近傍のヒストンH3修飾について

    • Author(s)
      鈴木俊英、北加代子、越智崇文
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Epigenetic regulation of gene expression

    • Author(s)
      Toshihide Suzuki
    • Organizer
      2nd Meeting of Nutrition and Natural Medicine on Health: Korea-Japan Research Collaboration
    • Place of Presentation
      Busan, KOREA
    • Related Report
      2013 Research-status Report
  • [Presentation] 3価無機ヒ素[iAs(III)]によるヒストンH3の修飾

    • Author(s)
      鈴木俊英、北加代子、越智崇文
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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