Variety of histone modifications by arsenic compounds, and the meanings of these modifications.
| Project/Area Number |
23510082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒ素化合物 / エピジェネティクス / ヒストン修飾 / 遺伝子誘導 / 細胞毒性 |
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| Outline of Final Research Achievements |
The purpose of this work was to evaluate the modification of histone by arsenic compounds, and to elucidate the meanings of these modifications.
Inorganic arsenite [iAs(III)] induced phosphorylation and methylation of histone H3, and phospho-histone H3 was observed as a punctual signals in specific region. Furthermore, we fund phospho-histone H3 was localized in the promoter region of FOS and EGR1, which were induced by iAs(III). These results suggested that the modification of histone changes chromatin structure and then induces gene expression.
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Report
(5 results)
Research Products
(6 results)
