| Project/Area Number |
23510123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Utsunomiya University |
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Principal Investigator |
UEHARA Nobuo 宇都宮大学, 工学(系)研究科(研究院), 准教授 (50203469)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Takeshi (80332633)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 金ナノ粒子 / 熱応答性高分子 / センシング / プローブ / バイオプローブ / チオール化合物 / 免疫センサー / センサー |
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| Outline of Final Research Achievements |
This research aims to elucidate a mechanism of fusion growth of gold nanoparticles conjugated with thermoresponsive polymers induced by thermal stimuli and to develop chemical probes measuring bio-related molecules based on the mechanism.
Elucidation of a mechanism of fusion growth of gold nanoparticles:We have found that 5-6 nm gold nanoparticles conjugated with thermoresponsive polymers fuse to grow as a result of being heated followed by being cooled. Some parameters such as temperature of a solution, heating time, types of inhibitors, and concentration of the inhibitors were in terms of TEM observation, spectrophotometry, dynamic light scattering, and small angle X-ray scattering to elucidate the mechanism. As a result, shrinkage of chains of the thermoresponsive polymers induced by heating a solution leaded to contact of the nanoparticles, resulting in the growth of the nanoparticles.
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