| Project/Area Number |
23510134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SHIBATA Osamu 長崎国際大学, 薬学部, 教授 (10117129)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAHARA Hiromichi 長崎国際大学, 薬学部薬学科, 講師 (00513235)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 表面・界面物性 / 肺サーファクタント / ナノ医薬品 / インテリジェント・ナノ材 料 / ラングミュアー単分子膜 / ナノ機能材料 / 呼吸窮迫症候群 / 偏光変調赤外反射吸収法 / インテリジェント・ナノ材料 / Langmuir単分子膜 / 呼吸窮迫症候群(RDS) / 偏光変調赤外反射吸収法(PM-IRRAS) / 表面電位ー面積等温線 / 偏光変調反射赤外分光法 / 原子間力顕微鏡 / 蛍光顕微鏡 / 表面電位ー面積等温泉 |
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| Research Abstract |
The model peptide in artificial pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives.
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