| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
In general, it happened apparently that a variety of gene amplification and deletion may interfere its expression and regulation. In the present study, I applied FISH technique to detect how the NOTCH3 gene is amplified in a mammary gland ductal carcinoma cell line of HC1143 and to make it narrow down a possible amplified genomic region commonly found in two of cell lines derived from primary effusion lymphomas. As a result, amplification of NOTCH3 gene was certified in HC1143 cells and a possible amplified region was narrowed down within the 1q25 region in PEL cell lines. However, disease causing candidate genes are not yet identified.
|
