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The role of testicular mono-ADP-ribosylation in men with idiopathic infertility

Research Project

Project/Area Number 23510242
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical genome science
Research InstitutionThe University of Tokushima

Principal Investigator

TAJIMA Atsushi  徳島大学, ヘルスバイオサイエンス研究部, 准教授 (10396864)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords遺伝子相互作用解析 / 遺伝リスク / 男性不妊症
Research Abstract

ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (18 results)

  • [Journal Article] Estrogen promotes Leydig cell engulfment by macrophages in male infertility.2014

    • Author(s)
      Yu W, Zheng H, Lin W, Tajima A, Zhang Y, Zhang X, Zhang H, Wu J, Han D, Rahman NA, Korach KS, Gao GF, Inoue I, Li X.
    • Journal Title

      J Clin Invest

      Volume: in press Issue: 6 Pages: 2709-2721

    • DOI

      10.1172/jci59901

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia2014

    • Author(s)
      Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
    • Journal Title

      Schizophrenia Bulletin

      Volume: 40(5) Issue: 5 Pages: 1154-63

    • DOI

      10.1093/schbul/sbt154

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population.2013

    • Author(s)
      Hata Y, Nakaoka H, Yoshihara K, Adachi S, Haino K, Yamaguchi M, Nishikawa N, Kashima K, Yahata T, Tajima A, Watanabe A, Akira S, Hosomichi K, Inoue I, Tanaka K.
    • Journal Title

      J Hum Genet.

      Volume: 58 Issue: 8 Pages: 517-520

    • DOI

      10.1038/jhg.2013.32

    • NAID

      10031195280

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia. Epigenetics2013

    • Author(s)
      Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T
    • Journal Title

      Epigenetics

      Volume: 8(6) Issue: 6 Pages: 584-590

    • DOI

      10.4161/epi.24621

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication study and meta-analysis of human nonobstructive azoospermia in Japanese populations.2013

    • Author(s)
      Sato Y
    • Journal Title

      Biol Reprod

      Volume: 88 Issue: 4 Pages: 87-87

    • DOI

      10.1095/biolreprod.112.106377

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA methylation signatures of peripheral leukocytes in schizophrenia2013

    • Author(s)
      Kinoshita M, Numata S, Tajima A, Shimodera S, Ono S, Imamura A, Iga JI, Watanabe S, Kikuchi K, Kubo H, Nakataki M, Sumitani S, Imoto I, Okazaki Y, Ohmori T
    • Journal Title

      Neuromolecular Med

      Volume: 15(1) Issue: 1 Pages: 95-101

    • DOI

      10.1007/s12017-012-8198-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population.2012

    • Author(s)
      Kinoshita M, et al
    • Journal Title

      Schizophr Res,

      Volume: 141(2-3): Issue: 2-3 Pages: 271-273

    • DOI

      10.1016/j.schres.2012.07.020

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway2012

    • Author(s)
      Kosuke Yoshihara
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Issue: 5 Pages: 1374-1385

    • DOI

      10.1158/1078-0432.ccr-11-2725

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hunting for genes for hypertension: the Millennium Genome Project for Hypertension.2012

    • Author(s)
      Tabara Y
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 6 Pages: 567-573

    • DOI

      10.1038/hr.2012.41

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders2012

    • Author(s)
      K. Koganebuchi, T. Katsumura, S. Nakagome, H. Ishida, S. Kawamura, H. Oota
    • Journal Title

      Anthropological Science

      Volume: 120 Issue: 3 Pages: 199-208

    • DOI

      10.1537/ase.120322

    • NAID

      10031145903

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan Populations.2012

    • Author(s)
      Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T, Naritomi K, Yanagi K, Niikawa N, Omoto K. Saitou N
    • Journal Title

      Journal of Human Genetics

      Volume: 57巻 Issue: 12 Pages: 787-79

    • DOI

      10.1038/jhg.2012.114

    • NAID

      10031145887

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.2011

    • Author(s)
      Nakabayashi K, Shirasawa S
    • Journal Title

      J Hum Genet

      Volume: 56(11) Issue: 11 Pages: 772-778

    • DOI

      10.1038/jhg.2011.99

    • NAID

      10030661591

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Systems Genetics Approach Provides a Bridge from Discovered Genetic Variants to Biological Pathways in Rheumatoid Arthritis2011

    • Author(s)
      Nakaoka Hirofumi; Cui Tailin; Tajima Atsushi, et al
    • Journal Title

      PLOS ONE

      Volume: 6:9 Issue: 9 Pages: e25389-e25389

    • DOI

      10.1371/journal.pone.0025389

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Genome-wide association study of plasma homocysteine and DNA methylation in patients with schizophrenia2013

    • Author(s)
      Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T
    • Organizer
      11^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional variants of the MTHFR gene and schizophrenia in the Japanese population2013

    • Author(s)
      Nishi A, Numata S, Tajima A, Kinoshita M, Shimodera S, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
    • Organizer
      Neuro 2013
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional variants of the MTHFR gene and schizophrenia in the Japanese population.2013

    • Author(s)
      Nishi A, Numata S, Tajima A, Kinoshita M, Shimodera S, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T.
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plasma homocysteine and schizophrenia: a gender-specific meta-analysis.2013

    • Author(s)
      Numata S, Kikuchi K, Tajima A, Kinoshita M, Shimodera S, Tomotake M, Imoto I, Ohmori T.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genome-wide methylation status of human leukocytes in mood disorders.2013

    • Author(s)
      Numata S, Kinoshita M, Tajima A, Shimodera S, Iga J, Watanabe S, Imoto I, Ohmori T.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genome-wide association study of plasma homocysteine and DNA methylation in patients with schizophrenia.2013

    • Author(s)
      Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] HNF1B、JAZF1 多型の前立腺がん発症リスクに関するメタアナリシス2012

    • Author(s)
      阿部夏季、菅恵梨、田嶋敦、井本逸勢
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多因子遺伝性疾患における遺伝的リスクの集団間差 : 東アジアにおける2 型糖尿病関連遺伝子多型を例として2012

    • Author(s)
      渡邉美恵、田嶋敦、井本逸勢
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] 生殖補助医療技術が出生時のDNA メチル化状態に及ぼす影響の検討2012

    • Author(s)
      久須美真紀、中林一彦、前原佳代子、田嶋敦、副島英伸、吉原一、 秦健一郎
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] HNF1B、JAZF1多型の前立腺がん発症リスクに関するメタアナリシス2012

    • Author(s)
      阿部夏季
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 多因子遺伝性疾患における遺伝的リスクの集団間差:東アジアにおける2型糖尿病関連遺伝子多型を例として2012

    • Author(s)
      渡邉美恵
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 生殖補助医療技術が出生時のDNAメチル化状態に及ぼす影響の検討2012

    • Author(s)
      久須美真紀
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan populations.2012

    • Author(s)
      Jinam T
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] マイクロ RNA ネットワークの遺伝的多様性とヒト疾患との関わり2011

    • Author(s)
      田嶋敦
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 関節リウマチにおけるシステムズ・ジェネティクス・アプローチ?感受性遺伝子座から生物学的経路の推定2011

    • Author(s)
      中岡博史、崔泰林、田嶋敦、光永滋樹、猪子英俊、井ノ上逸朗
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロRNAネットワークの遺伝的多様性とヒト疾患との関わり2011

    • Author(s)
      田嶋敦
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 関節リウマチにおけるシステムズ・ジェネティクス・アプローチ~感受性遺伝子座から生物学的経路の推定2011

    • Author(s)
      中岡博史
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 愛知がんセンター大規模病院疫学研究システムに基づくHLAクラスIIアレルとピロリ菌感染に関する横断研究2011

    • Author(s)
      田嶋敦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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