| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.
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