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Responsible genes for the aberrant production of MPO-ANCA

Research Project

Project/Area Number 23510244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical genome science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2012-2014)
Jichi Medical University (2011)

Principal Investigator

HAMANO Yoshitomo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (10281354)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsSCG/Kj / MPO-ANCA / 血管炎 / 半月体形成性糸球体腎炎 / マッピング / ANCA関連血管炎 / 自己免疫 / 自己免疫疾患
Outline of Final Research Achievements

The spontaneous crescentic glomerulonephritis-forming/Kinjoh (SCG/Kj) mouse is a unique model of vasculitis with production of MPO-ANCA. Genome wide mapping revealed the non-Fas susceptibility locus of MPO-ANCA on chromosome 1, designated as Man-1. The aim of this study is to identify the responsible gene (s) of Man-1. Interval mapping created single peak of LOD curve on the Gene A, a protein-coding gene with unknown function. Because of the highest LOD score, Gene A was the first positional candidate gene. Recombinant Gene A accelerated the proliferation of murine myeloid cell line Mcl33D. However, transfection of Gene A to Mcl33D did not influenced to expression levels of leukocyte activation markers.
We established SCG/Kj-derived interval congenic mice with B6 background. Fortunately, we obtained mice with recombination between B6 and SCG/Kj at the midpoint of Man-1 interval. These mice will help us to narrow down positional candidate genes on Man-1 interval.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) Book (8 results) Remarks (1 results)

  • [Journal Article] Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan.2014

    • Author(s)
      Furuta, S., Chaudhry, AN., Hamano, Y., Fujimoto, S., Nagafuchi, H., Makino, H., Matsuo, S., Ozaki, S., Endo, T., Muso, E., Ito, C., Kusano, E., Yamagata, M., Ikeda, K., Kashiwakuma, D., Iwamoto, I., Westman, K. and Jayne, D.
    • Journal Title

      J Rheumatol.

      Volume: 41(2) Issue: 2 Pages: 325-33

    • DOI

      10.3899/jrheum.130602

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis2014

    • Author(s)
      Suzuki K, Nagao T, Itabashi M, Hamano Y, Sugamata R, Yamazaki Y, Yumura W, Tsukita S, Wang PC, Nakayama T, Suzuki K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 29 Issue: 6 Pages: 1168

    • DOI

      10.1093/ndt/gft469

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Susceptibility QTLs for pathogenic leukocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model.2014

    • Author(s)
      Hamano Y, Abe M, Matsuoka S, Zhang D, Kondo Y, Kagami Y, Ishigami A, Maruyama N, Tsuruta Y, Yumura W, Suzuki K
    • Journal Title

      Clin Exp Immunol.

      Volume: 2014 Mar 24. Issue: 1 Pages: 353-365

    • DOI

      10.1111/cei.12333

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic leukocytosis and their susceptibility QTLs for vasculitis and crescentic glomerulonephritis in a model of SCG/Kj mice.2013

    • Author(s)
      Hamano, Y., Yumura, W., Maruyama, N., Suzuki, K.
    • Journal Title

      La Presse Medicale & Quarterly Medical Review

      Volume: 42(4) Pages: 687-687

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis.2013

    • Author(s)
      Suzuki K, Nagao T, Itabashi M, Hamano Y, Sugamata R, Yamazaki Y, Yumura W, Tsukita S, Wang PC, Nakayama T, Suzuki K.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 2013 Dec 5.

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome.2012

    • Author(s)
      Hamano Y, Yoshizawa H, Sugase T, Miki T, Ohtani N, Hanawa S, Takeshima E, Morishita Y, Saito O, Takemoto F, Muto S, Yumura W, Kusano, E.
    • Journal Title

      Case Reports in Nephrol Urol

      Volume: 2 Pages: 92-101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011

    • Author(s)
      Zhang D, Kobayashi T, Hino O, et al
    • Journal Title

      Cancer Sci

      Volume: 102(4) Issue: 4 Pages: 720-7

    • DOI

      10.1111/j.1349-7006.2011.01846.x

    • NAID

      10029291977

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 腎疾患における抗moesin抗体の病的意義2014

    • Author(s)
      濱野慶朋、鶴田悠木、佐野夏帆、丸山直記、湯村和子、佐々木裕子、亀岡洋祐、鈴木和男
    • Organizer
      第57回 日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎動脈狭窄症とC型肝炎に合併した大量タンパク尿の一例2013

    • Author(s)
      濱野慶朋、佐野夏帆、勒寺紀栄、久保里奈、鶴田悠木、湯村和子
    • Organizer
      第18回板橋区医師会医学会
    • Place of Presentation
      板橋区民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] MPO-ANCA関連血管炎自然発症モデルマウスにおける腎炎・自己免疫形質とサイトカイン動態との関連2012

    • Author(s)
      濱野慶朋、長尾朋和、吉澤寛道、草野英二、鈴木和男、湯村和子
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 顆粒球吸着療法(GCAP)で解熱・軽快した成人発症型周期性発熱症候群の一例2012

    • Author(s)
      濱野慶朋、吉澤寛道、大谷尚子、三木拓也、武島えり、斉藤修、森下義幸、湯村和子、武藤重明、竹本文美、草野英二
    • Organizer
      日本透析医学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Genomics and Genetics in ANCA-associated Vasculitis.2012

    • Author(s)
      Yoshitomo Hamano
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop(招待講演)
    • Place of Presentation
      Shinagawa, Tokyo, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of IL-17/IL-23 axis and pro-inflammatory cytokines in the pathogenesis of spontaneously occurring glomerulonephritis in a model of SCG/Kj mice.2012

    • Author(s)
      Yoshitomo Hamano, Tomokazu Nagao, Kazuo Suzuki, Hiromichi Yoshizawa, Eiji Kusano and Wako Yumura
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop
    • Place of Presentation
      Shinagawa, Tokyo, Japan
    • Related Report
      2011 Research-status Report
  • [Book] 見逃すと怖い血管炎2014

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      170
    • Publisher
      日本医事新報社
    • Related Report
      2014 Annual Research Report
  • [Book] ループス腎炎.In安田隆(編)臨床腎臓内科学2013

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      12
    • Publisher
      南山堂
    • Related Report
      2013 Research-status Report
  • [Book] 膠原病・RA・オーバーラッピング症候群と腎障害.安田隆(編)臨床腎臓内科学2013

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      3
    • Publisher
      南山堂
    • Related Report
      2013 Research-status Report
  • [Book] 強皮症腎.安田隆(編)臨床腎臓内科学2013

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      5
    • Publisher
      南山堂
    • Related Report
      2013 Research-status Report
  • [Book] 新領域別症候群シリーズ 血管炎 V. ANCA関連血管炎の病因・病理、診断・治療 1. ANCA関連血管炎(AAV)の基礎研究から臨床へのアプローチ (1)ゲノミクスと遺伝子解析 疾患モデルマウスによる疾患関連遺伝子の解析.2013

    • Author(s)
      濱野慶朋、丸山直記、湯村和子、鈴木和男
    • Total Pages
      10
    • Publisher
      日本臨床社
    • Related Report
      2012 Research-status Report
  • [Book] 新領域別症候群シリーズ No. 18 腎臓症候群(第2版)下巻 -その他の腎臓疾患を含めて- XII 各種病態にみられる腎障害 造血器疾患 多発性骨髄腫2012

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      7
    • Publisher
      日本臨床社
    • Related Report
      2012 Research-status Report
  • [Book] CKD(主に保存期腎不全)の患者さんの管理.Q&A21.高齢者に多い急速進行性糸球体腎炎ってどんな病気なの?2012

    • Author(s)
      濱野慶朋
    • Total Pages
      4
    • Publisher
      日本医事新報社
    • Related Report
      2012 Research-status Report
  • [Book] 別冊日本臨床 新領域別症候群シリーズ No. 18 腎臓症候群(第2版)2012

    • Author(s)
      濱野慶朋、湯村和子
    • Total Pages
      8
    • Publisher
      日本臨床社
    • Related Report
      2011 Research-status Report
  • [Remarks] 東京都健康長寿医療センター 研究所

    • URL

      http://www.tmghig.jp/J_TMIG/J_index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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