| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Myo-inositol is a promising material as a biomass. To realize this subject, a regioselective substitution on a desired OH group among six ones in inositol should be developed. It has been the most difficult problem, but we have found that dissolution of inositol in LiCl-dimethylacetamide or dimethylsulfoxide successfully promotes a substitution reaction to yield a regioselective 1,3-di-O- or 1-O-substitution product respectively depending on a amount of an electrophile. Desymmetrization of 1,3-diacetyl-myo-inositol by lipase produced monoacetate in a good yield with high optical purity (96% ee).
These fundamental research results directed us to design and synthesize a candidate of a surfactant and a monomer for a functional polymer, aiming at the use of myo-inositol as a biomass.
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