Development of an assay method to search for compounds inhibiting stress-enhanced allergy
| Project/Area Number |
23510268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKU Hisae 武庫川女子大学, 薬学部, 助教 (90281518)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAOKA Emiko 兵庫医療大学, 薬学部, 助教 (60411980)
OGAWA Yuko 同志社女子大学, 薬学部, 助教 (00454497)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | アレルギー / ストレス / 血流量 / 卵白リゾチーム (HEL) / アッセイ法の開発 / 病体モデルマウス / 卵白リゾチーム（HEL） / マウス / in vivo |
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| Research Abstract |
Allergic disorders, such as atopic dermatitis and asthma, become severe or relapse by stress. Since stress is an important factor affecting blood stream, we have developed a new assay system based upon our findings on lowering blood stream at an induction phase of allergy in mice sensitized by egg-white lysozyme (HEL).
Using this novel assay system, we evaluated natural herbal medicines that are clinically used to treat stress or allergic disorders. Our model should be useful for identifying potential anti-stress-enhanced allergy drugs.
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Report
(4 results)
Research Products
(58 results)
