Search of naturally-occurring anti-cancer agent targeted to a practical biological molecules derived from clinical cancer cells.
| Project/Area Number |
23510284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
AOKI SHUNJI 兵庫医療大学, 薬学部, 教授 (60252699)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIKAWA KAZUTAKE 大阪大学, 大学院薬学研究科, 教授 (10207376)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PCA-1 / DNA, RNA脱メチル化酵素 / 前立腺がん / 膵臓がん / 分子標的抗がん剤 / アポトーシス / DNA脱メチル化酵素 |
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| Outline of Final Research Achievements |
A DNA and/or RNA-alkylating damage-repair enzyme called prostate cancer antigen (PCA)-1 is highly expressed in clinical androgen-independent prostate cancer cells and pancreatic cancer cells. Genetic inhibition of the enzymatic activity by injecting siRNA effectively inhibited the growth of prostate and pancreatic cancer cells. Therefore, PCA-1 inhibitor would be a novel and clinically effective anti-cancer drug against prostate cancer, even for hormone independent varieties and pancreatic cancer.
On the other hand, on the guidance of inhibition against PCA-1 enzymatic activity, we tried to search for anti-cancer substances from extracts of medicinal plants. We found several active extract and isolate the active components by the assay-guided separation.
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Report
(6 results)
Research Products
(14 results)
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[Journal Article] Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.2014
Author(s)
S. Nakao, M. Mabuchi, T.Shimizu, Y. Itoh, Y. Takeuchi, M. Ueda, H. Mizuno, N. Shigi, I. Ohshio, K. Jinguji, Y. Ueda, M. Yamamoto, T. Furukawa, S. Aoki, K. Tsujikawa, A. Tanaka
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Journal Title
Bioorg Med Chem Lett.
Volume: 24
Pages: 1071-1074
DOI
Related Report
Peer Reviewed
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