| Project/Area Number |
23510345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gender
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IZUTSU Yumi 新潟大学, 自然科学系, 准教授 (20301921)
WATANABE Hisami 琉球大学熱帯生物圏研究センター, 分子生命科学研究施設・感染免疫制御分野, 教授 (50143756)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肝樹状細胞 / 自己免疫性肝炎 / エストロゲン / CD274 / IL-10 / 免疫調節 / IL-12 / エストロゲン受容体 / 17β-estradiol / エストラジオール / 肝内樹状細胞 / PD-L1/PD-L2 / 自己抗体 |
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| Research Abstract |
It has been reported that autoimmune hepatitis is induced by the drastic change of sex hormone, such as pregnancy and menopause. However, its pathogenic mechanism is not well-known. In this study, we focused on the hepatic dendritic cells. We used the mouse model of autoimmune hepatitis to investigate the effect of the autologous reactivity of estrogen. As a result, it was shown that the autoimmune liver injury of the mice was inhibited by the administration of estrogen. At the same time, the number of CD274+ immature dendritic cells was increased in the liver of those autoimmune hepatitis mice. Moreover only these dendritic cells showed the elevated ability to produce IL-10. At the same time they indicated the decreased serum level of IL-12. These results suggested that the inhibitory dendritic cells, which were increased in the liver by estrogen exposure, suppressed the autoimmune liver injury.
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