| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
Against the backdrop of the internet and online game addiction, this study designed an animal model to understand sensory reinforcement through visual and audio stimulation. We investigated the model's underlying neuromechanisms assuming that behavioral reinforcement occurred through audiovisual stimulation. Our studies in 2011 and 2012 utilized music/noise (audio stimulation) and lights (visual stimulation), respectively, as reinforcers to confirm the conditioning of rats to pressing levers (sensory reinforcement). In 2013, we examined the effects of destruction of the nucleus accumbens region containing terminal portions of dopaminergic neurons. This was followed by studies of destruction of dopaminergic neurons in the nucleus accumbens in 2014. We then focused on nerves actuated by intracerebral dopamine, which that are thought to be involved in addiction mechanisms.
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